Mesenchymal tumours of the mediastinum—part II

Bakker, Michael A. den; Marx, Alexander; Mukai, Kiyoshi; Ströbel, Philipp

doi:10.1007/s00428-015-1832-6

Cited by 35 publications

(59 citation statements)

References 210 publications

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“…Despite its rarity in the thorax, this tumor is the most common malignant primary tumor of both the bony thorax and the entire chest wall, whereas mediastinal chondrosarcoma remains exceedingly scarce. Actually, less than ten cases of mediastinal chondrosarcoma have been reported (2,7) . Moreover, this malignancy is particularly unusual in the posterior mediastinum (3) .…”

Section: Discussionmentioning

confidence: 99%

“…They are grayish in color, opaque, soft in consistency, with a gelatinous aspect, sometimes pseudocystic. The cartilaginous islets are often voluminous, coalescent, and poorly limited, with at most the loss of the lobulated aspect of cartilaginous tumors (6,7) . Histologically, based on cellular density, the degree of anisokaryosis, and nuclear hyperchromatism, chondrosarcomas are divided into three grades of increasing aggressivity according to the World Health Organization (WHO) classification (Table1) (6) .…”

Section: Discussionmentioning

confidence: 99%

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Posterior Mediastinal Chondrosarcoma Presenting as a Dumbbell-shaped Mass Mimicking a Cystic Schwannoma: An Unusual Presentation

Kouadir

Mazghi²,

Hassouni³

et al. 2017

IAM

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Mediastinal chondrosarcoma is exceedingly rare. Moreover, it is particularly unusual in the posterior mediastinum. Actually, very few cases of chondrosarcoma of the posterior mediastinum are gleaned from the literature. On the other hand, neurogenic tumors make even more than 75% of all tumors in the posterior mediastinum, and they are most often schwannomas that account for about 90% of all dumbbell-shaped tumors. Exceptionally, a dumbbell-shaped mass may correspond to a chondrosarcoma. We report a case of a 48-year-old Moroccan woman who presented with a complaint of intermittent electric shock type pain in the right side of chest radiating to the ipsilateral arm over six months period. No apparent distress or mass was found during the physical examination. Chest X-ray showed wellcircumscribed opacity located in the upper right part of the posterior mediastinum. Neck and chest computed tomography (CT) scans followed by magnetic resonance imaging (MRI) were carried out and revealed a dumbbellshaped mass of the posterior mediastinum. Such radiologic findings have oriented towards the diagnosis of cystic schwannoma. As pathologic results were inconclusive after a CT-guided fine needle biopsy, the patient underwent tumor resection via right posterolateral thoracotomy. Histopathological examination of surgical resection specimen revealed a grade II chondrosarcoma with the invasion of peripheral margins. Therefore, the patient received adjuvant radiation therapy to the tumor bed. Our case suggests that in the case of a dumbbell-shaped or thoracic paravertebral tumor a diagnosis other than nerve sheath tumor should be considered, including chondrosarcoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Posterior Mediastinal Chondrosarcoma Presenting as a Dumbbell-shaped Mass Mimicking a Cystic Schwannoma: An Unusual Presentation

Kouadir

Mazghi²,

Hassouni³

et al. 2017

IAM

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“…These findings were similar to study done by Singh et al and Dasgupta et al 10 An extensive review article of mediastinal mesenchymal lesions by Michael A. Den Bakker, Alexander Marx, Kiyoshi Mukai and Philipp Ströbel described 20 soft tissue tumours of the mediastinum and had similar findings as our study. 11,12 All germ cell tumours were detected in the anterior mediastinum, the most common case being benign cystic teratoma. An interesting case encountered in our study was a mixed malignant germ cell tumour with yolk sac and immature teratomatous components seen in a 38-year-old male.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Profile of Mediastinal Lesions- A Five-Year Study From a Tertiary Care Centre in South India

Amanullah¹,

Vilasiniamma²,

Pothen³

et al. 2017

jemds

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BACKGROUNDThe mediastinum is the central limited space of the thoracic cavity, which houses a variety of neoplastic and non-neoplastic lesions. Accurate diagnosis is warranted owing to the variable therapeutic and prognostic implications. The aims of this study are to study the frequency and distribution of mediastinal tumours and tumour-like lesions and to study the histomorphological patterns of the various mediastinal lesions.

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“…Taj je naziv uvela Svjetska zdravstvena organizacija 2003. godine za tumore maternice, a kasnije se koristi i za druge lokalizacije SMT-a 12 . Do sada je u literaturi opisano oko 20 slučajeva primarnih medijastinalnih LM-a i oko 40 slučajeva medijastinalnih LMS-a 13 . Bili su to prikazi jednog slučaja ili male serije slučajeva 10,14-21 .…”

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Mediastinal smooth muscle tumor of uncertain malignant potential: case report and literature review

Flego¹,

Volarić

Matušan-Ilijaš

et al. 2019

Med flum

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Sažetak. Cilj: glatkomišićni tumori su lejomiomi i lejomiosarkomi. Postoji rijetka skupina, u kojoj se biološki potencijal tumora ne može utvrditi; to su glatkomišićni tumori nepoznatog malignog potencijala. Cilj je prikazati pacijenta s takvim tumorom, koji je nastao iz glatkog mišićnog tkiva medijastinuma. Prikaz slučaja: 48-godišnji muškarac, subfebrilan, bolovi u grudnom košu sa širenjem u leđa. Kompjutorizirana tomografija toraksa pokazala je oštro ograničenu cističnu tvorbu stražnjeg medijastinuma. Ezofagogastroduodenoskopija je otkrila u srednjoj trećini jednjaka pritisak izvana, a rendgen pasaža jednjaka jednjak lučno potisnut izvana prema desno i ventralno. Bronhoskopijom je utvrđeno da je membranozni dio lijevog glavnog bronha blago ekstramuralno komprimiran. Učinjen je kirurški zahvat, torakotomija lijevo i potpuno odstranjenje tumora medijastinuma. Patohistološki nalaz pokazao je područje nekroze, tumorsko tkivo građeno od vretenastih stanica, koje pokazuju blagu polimorfiju. Imunohistokemijska analiza tumora bila je pozitivna na glatkomišićni aktin (SMA) i dezmin, a negativna na S100 i CD34, što potvrđuje podrijetlo tumora iz glatkomišićnih stanica. Dodatna imunohistokemijska analiza utvrdila je da proliferacijski biljeg Ki-67 iznosi 5,9 %, a p16 je pozitivan u više od 50 % tumorskih stanica. Zaključni patološki nalaz je glatkomišićni tumor nepoznatog malignog potencijala. Pacijent je praćen 48 mjeseci nakon operacije, bez recidiva tumora ili znakova metastaza. Zaključak: Patohistološka dijagnoza može biti otežana, općenito, ali posebno u rijetkim novotvorevinama. Prikazani slučaj pokazuje da ponekad nije moguće utvrditi radi li se o benignom ili malignom glatkomišićnom tumoru. Tada se postavlja dijagnoza glatkomišićnog tumora nepoznatog malignog potencijala, ovdje smještenog u medijastinumu. Nakon kirurškog odstranjenja neoplazme potrebno je redovito pratiti pacijenta, kako bi se utvrdio recidiv bolesti i provelo dodatno liječenje. Abstract. Aim: Smooth muscle tumors are divided into leiomyomas and leiomyosarcomas.The aim is to present a patient with a rare tumor called smooth muscle tumor of uncertain malignant potential. Case report: The reported patient was a 48-year-old male, subfebrile, with chest pain. Chest computed tomography showed a sharply limited cystic formation of the posterior mediastinum. Esophagogastroduodenoscopy revealed outside compression in the middle third of the esophagus, and X-ray of the esophageal passage showed that the esophagus was pressed from the outside to the right and ventral. Bronchoscopy determined that the membranous part of the left main bronchus was slightly extramurally compressed. A left thoracotomy and an extirpation of the mediastinal tumor were performed. In pathohistology area of necrosis and tumor tissue composed of spindle cells were identified, which showed mild polymorphia. Immunohistochemical findings included positive smooth muscle actin (SMA) and desmin markers, negative S100 and CD34 markers, Ki-67 was 5.9%, and p16 was positive in more than 50% ...

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Mesenchymal tumours of the mediastinum—part II

Cited by 35 publications

References 210 publications

Posterior Mediastinal Chondrosarcoma Presenting as a Dumbbell-shaped Mass Mimicking a Cystic Schwannoma: An Unusual Presentation

Posterior Mediastinal Chondrosarcoma Presenting as a Dumbbell-shaped Mass Mimicking a Cystic Schwannoma: An Unusual Presentation

Histopathological Profile of Mediastinal Lesions- A Five-Year Study From a Tertiary Care Centre in South India

Mediastinal smooth muscle tumor of uncertain malignant potential: case report and literature review

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