Mesenchymal tumors of the stomach: radiologic and pathologic correlation

Madhusudhan, Kumble Seetharama; Das, Prasenjit

doi:10.1007/s00261-022-03498-1

Cited by 9 publications

(12 citation statements)

References 89 publications

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“…Our case mirrors other PF cases histopathologically in presenting with a multinodular proliferation of bland spindle cells and arborizing capillaries in a myxoid stroma. Similarly, minimal cytologic atypia and low mitotic count have consistently reported in previous cases [ [7] , [8] , [9] ]. PF may easily be under recognized or misinterpreted without the pathologists' awareness of this entity and performing unnecessarily many immunostains.…”

Section: Discussionsupporting

confidence: 76%

Viscus perforation as an initial presentation of plexiform fibromyxoma: A case report and review of the literature

Mremi

Nyoni

Elisante

et al. 2023

International Journal of Surgery Case Reports

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Section: Discussionsupporting

confidence: 76%

Viscus perforation as an initial presentation of plexiform fibromyxoma: A case report and review of the literature

Mremi

Nyoni

Elisante

et al. 2023

International Journal of Surgery Case Reports

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“…8 Most tumors originate from the body's mesenchymal tissue. 9 In 1991, Weidner et al classified TIO into four categories based on histopathological features: phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT), osteoblastoma-like variant, ossified fibroids-like variant, and non-ossifying fibroma-like variant. 10 Despite advancements in understanding the disease, diagnosing and treating TIO remains challenging due to the variable size and distribution of the causative tumor in the body, which even advanced imaging techniques may fail to detect.…”

Section: Discussionmentioning

confidence: 99%

“…FGF23 causes hypophosphatemia through renal phosphate wasting, and a decline in 1, 25‐dihydroxy vitamin D synthesis leads to osteomalacia, which is characterized by muscle weakness, diffuse bone pain, and multiple fractures 8 . Most tumors originate from the body's mesenchymal tissue 9 . In 1991, Weidner et al.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of tumor‐induced osteomalacia mismanaged due to misdiagnosis: A literature review based on a case report

Fatollahzadeh,

Meybodi,

Pajavand

et al. 2024

Clinical Case Reports

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Key Clinical MessageTumor‐induced osteomalacia is a rare but potentially serious disease with nonspecific misguiding manifestations that can result in a wrong diagnosis and being treated for rheumatologic or other similar diseases. In patients with unexpected fractures, resistant musculoskeletal pains, and hypophosphatemia, this diagnosis should be considered by the physicians and approached through a complete history taking, physical exam laboratory, and radiologic evaluation to give the opportunity of on‐time treatment to the patient.AbstractTumor‐induced osteomalacia (TIO) is an uncommon mesenchymal tumor that results in disproportionate phosphorus excretion, primarily leading to bone‐related symptoms. Laboratory, imaging, and histopathological evaluation can confirm this pathologic condition. In this case, we present the history and subsequent clinical parts of a 50‐year‐old woman who presented with an unusual presentation of generalized musculoskeletal pains and a right ankle mass. Her disease was diagnosed with multidisciplinary evaluation and was approached by a surgical treatment. The patient was treated with total resection of the tumor, which led to complete resolution of musculoskeletal and metabolic abnormalities, which were resolved following total tumor resection. TIO is a paraneoplastic disease that results in abnormal secretion of phosphatonins, particularly fibroblast growth factor 23 (FGF23). This can cause hypophosphatemia, hyperparathyroidism, lower bone density, and increased risk of pathologic fractures. These tumors are mostly cured by surgical ± radiotherapy. The present study aims to provide insight into the fact that a TIO diagnosis is not always straightforward. However, in suspicious cases such as unexplained hypophosphatemia, it should be considered to prevent delayed diagnosis of the progressive pathology. The earlier treatment can prevent several complications and reduce the risk of mortality.

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“…EUS-FNA is often sufficient to obtain a specimen for a gastric submucosal mass lesion, and a diagnosis can be made by combining HE staining and immunohistochemical staining [ 3 ]. In this case, HE staining showed bundles of tumor cells with acidophilic deposits, which suggested a spindle cell type of GIST [ 4 ]. However, additional immunostaining for c-kit was partially positive and difficult to determine.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic and Endoscopic Cooperative Surgery for Gastric Submucosal Tumor Near Esophagogastric Junction With Sliding Hiatal Hernia

Kashima¹,

Kikuchi²,

Kuroda³

et al. 2023

Cureus

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The usefulness of laparoscopic and endoscopic cooperative surgery (LECS) for gastric submucosal tumors in the cardiac region has been reported in recent years. However, LECS for submucosal tumors at the esophagogastric junction with hiatal sliding esophageal hernia has not been reported, and its validity as a treatment method is unknown. The patient was a 51-year-old man with a growing submucosal tumor in the cardiac region. Surgical resection was indicated because a definitive diagnosis of the tumor was not determined. The lesion was a luminal protrusion tumor, located on the posterior wall of the stomach 20 mm from the esophagogastric junction, and had a maximum diameter of 16.3 mm on endoscopic ultrasound examination. Because of the hiatal hernia, the lesion could not be detected from the gastric side by endoscopy. Local resection was considered to be feasible because the resection line did not extend into the esophageal mucosa and the resection site could be less than half the circumference of the lumen. The submucosal tumor was resected completely and safely by LECS. The tumor was diagnosed as a gastric smooth muscle tumor finally. Nine months after surgery, a follow-up endoscopy showed reflux esophagitis. LECS was a useful technique for submucosal tumors of the cardiac region with hiatal hernia, but fundoplication might be considered for preventing backflow of gastric acid.

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Mesenchymal tumors of the stomach: radiologic and pathologic correlation

Cited by 9 publications

References 89 publications

Viscus perforation as an initial presentation of plexiform fibromyxoma: A case report and review of the literature

Viscus perforation as an initial presentation of plexiform fibromyxoma: A case report and review of the literature

Unusual presentation of tumor‐induced osteomalacia mismanaged due to misdiagnosis: A literature review based on a case report

Laparoscopic and Endoscopic Cooperative Surgery for Gastric Submucosal Tumor Near Esophagogastric Junction With Sliding Hiatal Hernia

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