Mesenchymal Tumors of the Skull Base with Particular Reference to Surgical Management and Outcome

Shotton, J. C.; Kuhwoede, R.; Fisch, Ugo

doi:10.1055/s-2008-1057120

Cited by 20 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are most frequently found in the atrium of the heart and jaw bone and occur less frequently in the cranial base of the brain. 16,33,35,37,38 From an etiological perspective, intracranial myxomas have either a primary or secondary origin. Initially, the majority of primary myxomas are found at the skull base, whereas secondary intracranial myxomas are mainly caused by metastatic tumor emboli from cardiac myxomas.…”

mentioning

confidence: 99%

Surgical management and prognostic factors for primary intracranial myxoma: a single-institute experience with a systematic review

Weng

Song

et al. 2019

Journal of Neurosurgery

View full text Add to dashboard Cite

OBJECTIVEPrimary intracranial myxomas (PICMs) are extremely rare neoplasms, and their management and prognostic factors remain ambiguous. The authors aimed to elaborate the radiological features, evaluate the risk factors for progression-free survival (PFS), and propose a treatment protocol based on pooled data from cases treated at their institute and those found in the literature.METHODSClinical data from all cases of PICMs treated at the authors’ institute and those cases reported in the English-language literature between 1987 and December 2017 were reviewed. The authors searched the Ovid MEDLINE, Embase, PubMed, and Cochrane databases using the keywords “myxoma” and “central nervous system,” “intracranial,” “cerebral,” “skull base,” “skull,” or “brain.” Previously published data were processed and used according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Risk factors in the pooled cohort were evaluated.RESULTSCases from the authors’ institute included 21 males and 9 females, with a mean age of 35.7 ± 1.7 years. Gross-total resection (GTR) and non-GTR were achieved in 6 (20.0%) and 24 (80.0%) patients, respectively. After a mean follow-up of 86.7 ± 14.1 months, recurrence occurred in 6 (24%) patients, for a median PFS time of 85.2 months (range 36.0–136.0 months) and no deaths. In the literature between 1987 and 2017, 35 cases of PICM were identified in 14 males and 21 females with a mean age of 31.7 ± 3.2 years. GTR and non-GTR were achieved in 23 (65.7%) and 9 (25.7%) cases, respectively. After a mean follow-up of 25.8 ± 6.9 months (range 1.0–156.0 months), recurrence occurred in 4 (14.3%) patients, for a median PFS time of 11.0 months (range 3.0–36.0 months) and no deaths. Actuarial PFS rates at 1, 5, and 10 years were 93.0%, 80.6%, and 67.9%, respectively. A multivariate model demonstrated that GTR (HR 0.058, 95% CI 0.005–0.680, p = 0.023) was the only factor that favored PFS.CONCLUSIONSPICMs are rare neoplasms with a slightly higher occurrence in males. GTR was the only favorable factor for PFS. Based on statistical results, GTR alone, if tolerable, is advocated as the optimal treatment for PICM. Nevertheless, conservative excision may be preferred to avoid damage to vital structures. PICMs have a tendency to recur within a few years of the initial surgery if resection is incomplete; therefore, close postoperative follow-up is mandatory. Future studies with larger cohorts are necessary to verify the study findings.Systematic review registration no.: CRD42018091517 (www.crd.york.ac.uk/prospero/)

show abstract

mentioning

confidence: 99%

Surgical management and prognostic factors for primary intracranial myxoma: a single-institute experience with a systematic review

Weng

Song

et al. 2019

Journal of Neurosurgery

View full text Add to dashboard Cite

show abstract

“…Although more rare, there are several case reports and small case series of skull base myxomas or fibromyxomas. 4 5 6 21 22 23 24 25 26 27 28 29 30 The typical patient and histopathologic features are identical to those found in the jaws, with the tumor occurring in virtually any location in the skull base and even the posterior fossa. Radical surgery is the primary treatment and necessary to minimize the risk of recurrence.…”

Section: Discussionmentioning

confidence: 76%

Fibromyxoma of the Lateral Skull Base in a Child: Case Report

et al. 2013

View full text Add to dashboard Cite

Purpose Fibromyxomas and myxomas are benign tumors of mesenchymal origin usually found outside the nervous system, most commonly in the atrium of the heart. They can also arise in the mandible or maxilla, but it is exceedingly rare to find them within the skull base. The history, histologic features, and the literature, with emphasis on other pediatric cases, are reviewed for this uncommon skull base neoplasm. Methods We describe the case of a 13-year-old girl who presented with a 1-year history of facial weakness, numbness, and hearing loss. A large locally destructive tumor centered in the petrous bone was found on magnetic resonance imaging. Results A mastoidectomy combined with a middle fossa craniotomy was performed for gross total resection. The child is disease free 12 months after surgery. Conclusion Diagnosis could not be made solely on radiographic studies because of the lack of pathognomonic imaging features. Radical resection provided the patient the best chance of cure. Long-term surveillance is necessary to monitor for tumor recurrence.

show abstract

“…Leiomyosarcomas are uncommon malignant neoplasms, accounting for less than 7-10% of all soft tissue sarcomas and only 1% of head and neck sarcomas [3,11]. Specifically, radiation-induced leiomyosarcomas of the head and neck are exceedingly rare, accounting for just 19 of all 323 (5.6%) reported cases of radiation-induced head and neck sarcomas between 1995 and 2014 [11][12][13]. We found one report of a spontaneous infratemporal fossa leiomyosarcoma reported in the literature [5].…”

Section: Discussionmentioning

confidence: 99%

“…Reported relative incidence of perineurial involvement in the head and neck varies. Most of the literature agrees that adenoid cystic carcinoma has the greatest disease-specific incidence of perineural spread [6,11,16,17]. In a retrospective series, the incidence of PS in the setting of adenoid cystic carcinoma was reported to be 31-96% [17].…”

Section: Figure 2 Hematoxylin and Eosin Staining Of The Tumor (Left) Demonstrates Markedly Atypical Spindle Cells With Blunted Nuclei Arrmentioning

confidence: 99%

Leiomyosarcoma of the Infratemporal Fossa With Perineurial Spread Along the Right Mandibular Nerve: a Case Report

et al. 2017

View full text Add to dashboard Cite

Leiomyosarcomas are malignant tumors displaying strong smooth muscle differentiation. They can often develop within the GI tract and myometrium, but are particularly rare in the head and neck. Perineurial spread of head and neck cancer is observed in patients with neoplasms of the skin (squamous cell carcinoma, melanoma) or skin appendages (adenoid cystic carcinoma). We report the case of a woman who presented with diplopia and headaches. MRI showed an infratemporal mass lesion and faint enhancement tracking along the mandibular nerve into the wall of the right cavernous sinus. A nerve biopsy revealed leiomyosarcoma. We review the medical literature to provide further insight into the diagnosis and management of this tumor and its peculiar pattern of spread. A similar case was unidentifiable in the literature.

show abstract

Mesenchymal Tumors of the Skull Base with Particular Reference to Surgical Management and Outcome

Cited by 20 publications

References 11 publications

Surgical management and prognostic factors for primary intracranial myxoma: a single-institute experience with a systematic review

Surgical management and prognostic factors for primary intracranial myxoma: a single-institute experience with a systematic review

Fibromyxoma of the Lateral Skull Base in a Child: Case Report

Leiomyosarcoma of the Infratemporal Fossa With Perineurial Spread Along the Right Mandibular Nerve: a Case Report

Contact Info

Product

Resources

About