Mesenchymal tumors of adult kidney

Samaratunga, Hemamali; Delahunt, Brett

doi:10.1053/j.semdp.2015.02.007

Cited by 16 publications

(35 citation statements)

References 133 publications

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“…Myopericytoma is defined as a member of the perivascular tumor family, which includes myofibroma, angioleiomyoma, glomus tumor, and myopericytoma, by the World Health Organization (WHO) classification (of tumor of soft tissue and bone) [ 2 ]. Myopericytoma occurs in various age groups, reported as ranging from 10 to 87 years; however, most are seen in adults with a median age of 49 years [ 3 ]. Regarding gender, a slight male predominance was reported in a male to female ratio of 1.25:1 [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Myopericytoma occurs in various age groups, reported as ranging from 10 to 87 years; however, most are seen in adults with a median age of 49 years [ 3 ]. Regarding gender, a slight male predominance was reported in a male to female ratio of 1.25:1 [ 3 ]. As mentioned above, the tumor generally arises in dermal and subcutaneous tissue, and occurrence in visceral or intracranial sites is extremely rare [ 2 – 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Mesenchymal tumor in the bladder accounts for less than 1 % of all bladder neoplasms [ 1 ]. Although benign mesenchymal tumors are also rare, leiomyoma is the most common, followed by hemangioma, solitary fibrous tumor, and neurofibroma [ 1 – 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Myopericytoma is a benign mesenchymal neoplasm composed of cytologically uniform presentation ranging from oval to spindle-shaped cells with a myoid appearance showing multilayered, perivascular concentric growth [ 2 , 3 ]. Myopericytoma is reported to occur typically in skin and superficial soft tissue, commonly in the distal and proximal extremities, and occasionally in the trunk, head, and neck.…”

Section: Introductionmentioning

confidence: 99%

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Myopericytoma in urinary bladder: a case report

et al. 2017

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BackgroundMyopericytoma is reported to occur mainly in the skin and superficial soft tissue of the extremities. In contrast, occurrence in the urinary bladder is extremely rare.Case presentationWe describe a 75-year-old Japanese man who developed a submucosal tumor at the right trigone of his bladder that led to interference with the discharge of right ureteral calculus. No invasive growth was observed by magnetic resonance imaging. Transurethral resection was successfully performed; histopathological analysis revealed perivascular proliferation of spindle-shaped to oval-shaped, cytologically bland tumor cells with eosinophilic cytoplasm. On immunohistochemical examination, the tumor cells were positive for alpha-smooth muscle actin, desmin, CD34 and h-caldesmon.ConclusionCystoscopic and pathological findings were compatible with a diagnosis of myopericytoma of the urinary bladder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Myopericytoma in urinary bladder: a case report

et al. 2017

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“…There is also a rare malignant variant of this neoformation, characterized by infiltrative growth towards deep tissue layers, high atypia and increased mitotic index. In these patients, in addition to a radical and extensive excision, it is necessary to use chemotherapy and adjuvant radiotherapy [15] , [19] , [20] , [21] , [22] , [23] , [24] . In literature there are 11 cases of myoperaciotosis with diffuse subcutaneous involvement by microscopic myopericytomatous nodules [25] .…”

Section: Discussionmentioning

confidence: 99%

Foot soft tissue myopericytoma: Case-report and review

Provenzano

Bianco

Belfiore

et al. 2017

International Journal of Surgery Case Reports

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Primary myxoid and epithelioid mesenchymal tumor of the kidney with a novel GLI1‐FOXO4 fusion

Pettus

Kerr

Stan

et al. 2020

Genes Chromosomes & Cancer

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To our knowledge, we describe the first mesenchymal tumor with a novel GLI1‐FOXO4 fusion gene. This well‐circumscribed kidney tumor displayed variably myxoid and epithelioid histologic features with a focally nodular growth pattern. The tumor cells showed bland, round to ovoid nuclei, with no overt high‐grade features. The tumor showed focal immunopositivity for smooth muscle actin and Melan‐A, which raised the possibility of a relationship with a perivascular epithelioid cell tumor. The clinical and morphologic features appear distinct from other reported neoplasms harboring GLI1 or FOXO4 gene rearrangements. The patient underwent radical nephrectomy and is without evidence of disease during a relatively short clinical follow‐up period. However, the features of this tumor likely warrant long‐term follow‐up to monitor for the possibility of a late recurrence or metastasis. In addition to reporting this novel fusion‐positive tumor, we also provide a brief review of GLI1 and FOXO4 gene functions in both normal and neoplastic contexts.

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Mesenchymal tumors of adult kidney

Cited by 16 publications

References 133 publications

Myopericytoma in urinary bladder: a case report

Myopericytoma in urinary bladder: a case report

Foot soft tissue myopericytoma: Case-report and review

Primary myxoid and epithelioid mesenchymal tumor of the kidney with a novel GLI1‐FOXO4 fusion

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