Mesenchymal Stromal Cells Over-expression Mutant IL-2 Enhance Treg Function in CIA Mice
Zhicheng Tang,
Fan Yang,
Jingyi Shen
et al.
Abstract:Objectives: Research indicates that low doses of interleukin-2
(IL-2) can effectively mitigate RA symptoms by promoting Treg cells,
while high doses may enhance immune responses. Consequently, this study
employed mutated IL-2 to minimize its impact on CD8
T and NK cell activation while preserving its influence on Treg cells.
Methods: We constructed IL-2 mutants by overlap PCR and
assessed its impact on the proliferation and functionality of Treg cells
by flow cytometry and PCR. Furthermore, the synergistic ef… Show more
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