Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice

Stamatopoulos, Alexandros; Stamatopoulos, Theodosios; Gamie, Zakareya; Kenanidis, Eustathios; Ribeiro, Ricardo; Rankin, Kenneth; Gerrand, Craig; Dalgarno, Kenneth; Tsiridis, Eleftherios

doi:10.1016/j.jbo.2019.100231

Cited by 27 publications

(23 citation statements)

References 204 publications

(211 reference statements)

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“…In a mouse cancer model, tumor was able to recruit ASCs from distant fat tissue sites through the systemic circulation, promoting tumor growth [46]. Cancer cells (CCs) together with its stroma and inflammatory cells secrete several factors such as MCP-1 and SDF-1 that induce ASCs homing and migration to tumor microenvironment [47].…”

Section: Implications Of Ascs and Their Adipokines And Chemokines mentioning

confidence: 99%

“…A possible explanation for these conflicting results arise from a multiplicity of factors influencing the interaction between ASCs and CCs, such as their origin and pre-treatments, cancer type and different in vitro and in vivo conditions (e.g., ASCs/CCs ratio, cell injection modality, kinetics of carcinogenesis) that may affect the experimental standardization [12]. However, as reported above, it’s a common belief that several secreted factors, produced by cancer and inflammatory cells, induce the homing and migration of ASCs into the tumor microenvironment [47].…”

Section: An Unexpected Effect From Adipocyte-secreted Exosomal Micmentioning

confidence: 99%

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Concise Review: Adipose-Derived Stem Cells (ASCs) and Adipocyte-Secreted Exosomal microRNA (A-SE-miR) Modulate Cancer Growth and proMote Wound Repair

Gentile

Garcovich

2019

JCM

117

108

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Adipose-derived stem cells (ASCs) have been routinely used from several years in regenerative surgery without any definitive statement about their potential pro-oncogenic or anti-oncogenic role. ASCs has proven to favor tumor progression in several experimental cancer models, playing a central role in regulating tumor invasiveness and metastatic potential through several mechanisms, such as the paracrine release of exosomes containing pro-oncogenic molecules and the induction of epithelial-mesenchymal transition. However, the high secretory activity and the preferential tumor-targeting make also ASCs a potentially suitable vehicle for delivery of new anti-cancer molecules in tumor microenvironment. Nanotechnologies, viral vectors, drug-loaded exosomes, and micro-RNAs (MiR) represent additional new tools that can be applied for cell-mediated drug delivery in a tumor microenvironment. Recent studies revealed that the MiR play important roles in paracrine actions on adipose-resident macrophages, and their dysregulation has been implicated in the pathogenesis of obesity, diabetes, and diabetic complications as wounds. Numerous MiR are present in adipose tissues, actively participating in the regulation of adipogenesis, adipokine secretion, inflammation, and inter-cellular communications in the local tissues. These results provide important insights into Adipocyte-secreted exosomal microRNA (A-SE-MiR) function and they suggest evaluating the potential role of A-SE-MiR in tumor progression, the mechanisms underlying ASCs-cancer cell interplay and clinical safety of ASCs-based therapies.

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Section: Implications Of Ascs and Their Adipokines And Chemokines mentioning

confidence: 99%

Section: An Unexpected Effect From Adipocyte-secreted Exosomal Micmentioning

confidence: 99%

Concise Review: Adipose-Derived Stem Cells (ASCs) and Adipocyte-Secreted Exosomal microRNA (A-SE-miR) Modulate Cancer Growth and proMote Wound Repair

Gentile

Garcovich

2019

JCM

117

108

View full text Add to dashboard Cite

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“…Dynamic and reciprocal interactions between epithelial and stromal cells occur during cancer progression by the exchange of cytokines, chemokines and growth factors, which develops a favorable microenvironment for cancer growth [58]. In addition, several secreted factors such as MCP-1 and SDF-1 produced by cancer and inflammatory cells, induce the homing and migration of non-resident ASCs into the tumor microenvironment [55]. Their recruitment into the tumor microenvironment promotes cancer growth, metastasis and stroma formation [59].…”

Section: Interplay Between Ascs and Cancer Cells: Mechanisms Undermentioning

confidence: 99%

“…Several conditions could influence the interaction between ASCs and cancer cells; in particular, cancer origin and histotype, as well as different treatment protocols (e.g., ASCs/cancer cells ratio, injection modality, kinetics of carcinogenesis) can potentially affect standardization [50]. However, it is commonly agreed that cancer and inflammatory cells release molecules that induce ASC homing and migration into tumor microenvironment [55].…”

Section: Interplay Between Ascs and Cancer Cells: Mechanisms Undermentioning

confidence: 99%

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Adipose-Derived Stem Cells in Cancer Progression: New Perspectives and Opportunities

Scioli

Storti

D’Amico

et al. 2019

IJMS

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Growing importance has been attributed to interactions between tumors, the stromal microenvironment and adult mesenchymal stem cells. Adipose-derived stem cells (ASCs) are routinely employed in regenerative medicine and in autologous fat transfer procedures. To date, clinical trials have failed to demonstrate the potential pro-oncogenic role of ASC enrichment. Nevertheless, some pre-clinical studies from in vitro and in vivo models have suggested that ASCs act as a potential tumor promoter for different cancer cell types, and support tumor progression and invasiveness through the activation of several intracellular signals. Interaction with the tumor microenvironment and extracellular matrix remodeling, the exosomal release of pro-oncogenic factors as well as the induction of epithelial-mesenchymal transitions are the most investigated mechanisms. Moreover, ASCs have also demonstrated an elective tumor homing capacity and this tumor-targeting capacity makes them a suitable carrier for anti-cancer drug delivery. New genetic and applied nanotechnologies may help to design promising anti-cancer cell-based approaches through the release of loaded intracellular nanoparticles. These new anti-cancer therapies can more effectively target tumor cells, reaching higher local concentrations even in pharmacological sanctuaries, and thus minimizing systemic adverse drug effects. The potential interplay between ASCs and tumors and potential ASCs-based therapeutic approaches are discussed.

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The heterogeneity and drug resistance of malignant cells and intercellular communication of microenvironment in osteosarcoma: Based on single‐cell analysis

Ma,

Wang,

Zhao

et al. 2023

Clinical and Translational Dis

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Background: Osteosarcoma (OS) is a prevalent bone cancer characterized by its aggressive nature, which often metastasizes to the lungs and contributes to a poor prognosis. Treatment progress has been hindered by drug resistance, distant metastases, and significant patient heterogeneity. However, recent advancements in technologies such as sequencing and multi-omics have enabled more in-depth investigations at the micro level.Aim: By undertaking a critical analysis of related studies, the present work intends to provide an overview of the microenvironmental features of osteosarcoma discovered through single-cell RNA sequencing (scRNA-seq) analysis. The articles included in this review were from several medical and health databases. Results and discussion: We also discuss drug resistance traits, taking into account the heterogeneity of OS cells within the tumor microenvironment (TME). This includes inherent and acquired resistance in both pre-and postchemotherapy osteosarcoma, as well as the close association between cancer stem cells (CSCs) and drug resistance. Additionally, we examine the intercellular communication between OS cells and other cell types, as revealed by both traditional and single-cell studies, and suggest several promising therapeutic targets. Conclusion:Single-cell RNA sequencing (scRNA-seq) provides a detailed view of the tumor microenvironment, revealing intercellular communication between osteosarcoma cells and other cells, and aiding in the identification of potential therapeutic targets.

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Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice

Cited by 27 publications

References 204 publications

Concise Review: Adipose-Derived Stem Cells (ASCs) and Adipocyte-Secreted Exosomal microRNA (A-SE-miR) Modulate Cancer Growth and proMote Wound Repair

Concise Review: Adipose-Derived Stem Cells (ASCs) and Adipocyte-Secreted Exosomal microRNA (A-SE-miR) Modulate Cancer Growth and proMote Wound Repair

Adipose-Derived Stem Cells in Cancer Progression: New Perspectives and Opportunities

The heterogeneity and drug resistance of malignant cells and intercellular communication of microenvironment in osteosarcoma: Based on single‐cell analysis

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