Mesenchymal stromal cell–derived magnetic nanovesicles for enhanced skin retention and hair follicle growth

Wang, Lei; Qiao, Shuya; Xia, Rushan; Liu, Yiwen; Hu, Yifei; Wu, Yihao; Zhou, Jiaju; Liang, Guozheng; Tian, Tian; Cao, Lei

doi:10.1016/j.jcyt.2023.07.001

Cited by 1 publication

(2 citation statements)

References 44 publications

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“…For example, MSC‐Exo incorporated with iron oxide nanoparticles can markedly improve the efficacy of targeted therapy for ischemic lesions 89 . Magnetic MSC‐Exo have also found beneficial effects on cardiac function recovery, 112 skin repair and wound healing, 177,178 maintenance of skin rejuvenation 179 and promotion of hair growth 179 . Except that, magnetic MSC‐Exo can induce magnetic hyperthermia while accurately targeting tumour cells 91 …”

Section: Effects Of Different Physical Factors On Msc‐exomentioning

confidence: 99%

“… 89 Magnetic MSC‐Exo have also found beneficial effects on cardiac function recovery, 112 skin repair and wound healing, 177 , 178 maintenance of skin rejuvenation 179 and promotion of hair growth. 179 Except that, magnetic MSC‐Exo can induce magnetic hyperthermia while accurately targeting tumour cells. 91 …”

Section: Effects Of Different Physical Factors On Msc‐exomentioning

confidence: 99%

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Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

Wu,

Zhao,

Xie

et al. 2024

Cell Proliferation

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Mesenchymal stem cell‐derived exosomes (MSC‐Exo) offer promising therapeutic potential for various refractory diseases, presenting a novel therapeutic strategy. However, their clinical application encounters several obstacles, including low natural secretion, uncontrolled biological functions and inherent heterogeneity. On the one hand, physical stimuli can mimic the microenvironment dynamics where MSC‐Exo reside. These factors influence not only their secretion but also, significantly, their biological efficacy. Moreover, physical factors can also serve as techniques for engineering exosomes. Therefore, the realm of physical factors assumes a crucial role in modifying MSC‐Exo, ultimately facilitating their clinical translation. This review focuses on the research progress in applying physical factors to MSC‐Exo, encompassing ultrasound, electrical stimulation, light irradiation, intrinsic physical properties, ionizing radiation, magnetic field, mechanical forces and temperature. We also discuss the current status and potential of physical stimuli‐affected MSC‐Exo in clinical applications. Furthermore, we address the limitations of recent studies in this field. Based on this, this review provides novel insights to advance the refinement of MSC‐Exo as a therapeutic approach in regenerative medicine.

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