2016
DOI: 10.1038/srep35998
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Mesenchymal stem cells with Sirt1 overexpression suppress breast tumor growth via chemokine-dependent natural killer cells recruitment

Abstract: Mesenchymal stem cells (MSCs) are generally used in regenerative medicine, tissue engineering and therapy for immune disorder diseases. However, due to the immunosuppressive function of MSCs, the application of MSCs in breast cancer therapy remains limited. Sirt1 is the closest mammalian homologue of the yeast enzyme Sir2 which has an established capacity to influence yeast replicative lifespan. In this study, we demonstrated the effect of MSCs with Sirt1 overexpression (MSCs-Sirt1) in mice bearing 4T1 breast … Show more

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Cited by 23 publications
(18 citation statements)
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“…SIRT1 overexpression inhibited human colon cancer cell proliferation 51 . Ectopic expression of SIRT1 in mesenchymal stem cells suppressed breast cancer growth 52 , while reduced SIRT1 levels in breast cancer cells led to increased metastasis through deacetylating Smad4 signaling 53 . According to previous studies, it remains controversial whether SIRT1 acts as an oncogene or tumor suppressor, and its specific functions may depend on diverse biological signaling.…”
Section: Discussionmentioning
confidence: 99%
“…SIRT1 overexpression inhibited human colon cancer cell proliferation 51 . Ectopic expression of SIRT1 in mesenchymal stem cells suppressed breast cancer growth 52 , while reduced SIRT1 levels in breast cancer cells led to increased metastasis through deacetylating Smad4 signaling 53 . According to previous studies, it remains controversial whether SIRT1 acts as an oncogene or tumor suppressor, and its specific functions may depend on diverse biological signaling.…”
Section: Discussionmentioning
confidence: 99%
“…These cells were able to recruit and polarize monocytes more efficiently than HD-MSCs thus sustaining malignant B-cell growth. Conversely, when MSCs were transfected to overexpress an NAD-dependent deacetylase sirtuin 1 (MSCs-Sirt1), they inhibited the growth of breast and prostate carcinomas by recruiting NK cells and macrophages [ 56 ]. Interestingly, MSCs associated in pancreatic carcinoma microenvironment had an increased tumor-promoting potential in respect to MSCs obtained from normal pancreas.…”
Section: Mesenchymal Stem Cells Modulate Tumor Immune Responsementioning
confidence: 99%
“…Accumulating evidence indicates that SIRT1 is a key regulator of diverse life events, including life span extension, inflammation, and cancer [ 24 ]. In cancer, the role of SIRT1 is controversial since it can function as both a tumor promoter and tumor suppressor [ 25 27 ]. SIRT1 can deacetylate histone H4 lysine 16 (H4K16) [ 28 ], whose hypoacetylation is a hallmark of human cancer [ 29 ].…”
Section: Discussionmentioning
confidence: 99%