Mesenchymal stem cells transporting black phosphorus-based biocompatible nanospheres: Active trojan horse for enhanced photothermal cancer therapy

Luo, Miaomiao; Zhou, Yun; Gao, Nansha; Cheng, Wei; Wang, Xusheng; Cao, Jinxiu; Zeng, Xiaowei; Gan, Li; Mei, Lin

doi:10.1016/j.cej.2019.123942

Cited by 47 publications

(33 citation statements)

References 40 publications

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“…Another most used SC method is the emulsion solvent evaporation method, often named as the oil‐in‐water emulsion solvent evaporation method. [ 64,71,72,105,107,119 ] In a typical procedure using this method, materials are first dispersed in organic solvents to form a homogeneous solution, which subsequently is added into an aqueous solution and sonicated to obtain the emulsion. Finally, the BP/polymer nanocomposites are obtained by centrifugation.…”

Section: Preparation Of Black Phosphorus/polymersmentioning

confidence: 99%

Black Phosphorus/Polymers: Status and Challenges

Zhang

Xie

et al. 2021

Advanced Materials

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As a newly emerged mono‐elemental nanomaterial, black phosphorus (BP) has been widely investigated for its fascinating physical properties, including layer‐dependent tunable band gap (0.3–1.5 eV), high ON/OFF ratio (104), high carrier mobility (103 cm2 V−1 s−1), excellent mechanical resistance, as well as special in‐plane anisotropic optical, thermal, and vibrational characteristics. However, the instability caused by chemical degradation of its surface has posed a severe challenge for its further applications. A focused BP/polymer strategy has more recently been developed and implemented to hurdle this issue, so at present BP/polymers have been developed that exhibit enhanced stability, as well as outstanding optical, thermal, mechanical, and electrical properties. This has promoted researchers to further explore the potential applications of black phosphorous. In this review, the preparation processes and the key properties of BP/polymers are reviewed, followed by a detailed account of their diversified applications, including areas like optoelectronics, bio‐medicine, and energy storage. Finally, in accordance with the current progress, the prospective challenges and future directions are highlighted and discussed.

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Section: Preparation Of Black Phosphorus/polymersmentioning

confidence: 99%

Black Phosphorus/Polymers: Status and Challenges

Zhang

Xie

et al. 2021

Advanced Materials

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“…The in vivo results proved the antitumor efficiency of the nanocomposites [ 126 ]. Hence, several studies proved BP efficacy as a PTT, PDT, and chemotherapeutic agent in cancer therapy [ 53 , 126 , 127 , 128 , 129 , 130 , 131 ].…”

Section: Biomedical Applications Of Black Phosphorusmentioning

confidence: 99%

Black Phosphorus as Multifaceted Advanced Material Nanoplatforms for Potential Biomedical Applications

et al. 2020

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Black phosphorus is one of the emerging members of two-dimensional (2D) materials which has recently entered the biomedical field. Its anisotropic properties and infrared bandgap have enabled researchers to discover its applicability in several fields including optoelectronics, 3D printing, bioimaging, and others. Characterization techniques such as Raman spectroscopy have revealed the structural information of Black phosphorus (BP) along with its fundamental properties, such as the behavior of its photons and electrons. The present review provides an overview of synthetic approaches and properties of BP, in addition to a detailed discussion about various types of surface modifications available for overcoming the stability-related drawbacks and for imparting targeting ability to synthesized nanoplatforms. The review further gives an overview of multiple characterization techniques such as spectroscopic, thermal, optical, and electron microscopic techniques for providing an insight into its fundamental properties. These characterization techniques are not only important for the analysis of the synthesized BP but also play a vital role in assessing the doping as well as the structural integrity of BP-based nanocomposites. The potential role of BP and BP-based nanocomposites for biomedical applications specifically, in the fields of drug delivery, 3D printing, and wound dressing, have been discussed in detail to provide an insight into the multifunctional role of BP-based nanoplatforms for the management of various diseases, including cancer therapy. The review further sheds light on the role of BP-based 2D platforms such as BP nanosheets along with BP-based 0D platforms—i.e., BP quantum dots in the field of therapy and bioimaging of cancer using techniques such as photoacoustic imaging and fluorescence imaging. Although the review inculcates the multimodal therapeutic as well as imaging role of BP, there is still research going on in this field which will help in the development of BP-based theranostic platforms not only for cancer therapy, but various other diseases.

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“…The BBB is a tight structure responsible for maintaining a homeostatic environment in the CNS [ 10 , 11 ]. The high transendothelial electrical resistance in conjugation with the presence of efflux pumps at the luminal side of the BBB prevents the crossing of lipophilic molecules, xenobiotics, toxic metabolites, and drugs [ 12 , 13 ]. The inability to efficiently cross the biological barriers and the systemic side effects are two of the main reasons for the limited availability of new chemotherapeutic agents for GBM treatment.…”

Section: Introductionmentioning

confidence: 99%

A New Chalcone Derivative with Promising Antiproliferative and Anti-Invasion Activities in Glioblastoma Cells

et al. 2021

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Glioblastoma (GBM) is the most common and most deadly primary malignant brain tumor. Current therapies are not effective, the average survival of GBM patients after diagnosis being limited to few months. Therefore, the discovery of new treatments for this highly aggressive brain cancer is urgently needed. Chalcones are synthetic and naturally occurring compounds that have been widely investigated as anticancer agents. In this work, three chalcone derivatives were tested regarding their inhibitory activity and selectivity towards GBM cell lines (human and mouse) and a non-cancerous mouse brain cell line. The chalcone 1 showed the most potent and selective cytotoxic effects in the GBM cell lines, being further investigated regarding its ability to reduce critical hallmark features of GBM and to induce apoptosis and cell cycle arrest. This derivative showed to successfully reduce the invasion and proliferation capacity of tumor cells, both key targets for cancer treatment. Moreover, to overcome potential systemic side effects and its poor water solubility, this compound was encapsulated into liposomes. Therapeutic concentrations were incorporated retaining the potent in vitro growth inhibitory effect of the selected compound. In conclusion, our results demonstrated that this new formulation can be a promising starting point for the discovery of new and more effective drug treatments for GBM.

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Mesenchymal stem cells transporting black phosphorus-based biocompatible nanospheres: Active trojan horse for enhanced photothermal cancer therapy

Cited by 47 publications

References 40 publications

Black Phosphorus/Polymers: Status and Challenges

Black Phosphorus/Polymers: Status and Challenges

Black Phosphorus as Multifaceted Advanced Material Nanoplatforms for Potential Biomedical Applications

A New Chalcone Derivative with Promising Antiproliferative and Anti-Invasion Activities in Glioblastoma Cells

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