2015
DOI: 10.1002/ijc.29709
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Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche

Abstract: Skeleton and liver are preferred organs for cancer dissemination in metastatic melanoma negatively impacting quality of life, therapeutic success and overall survival rates. At the target organ, the local microenvironment and cell-to-cell interactions between invading and resident stromal cells constitute critical components during the establishment and progression of metastasis. Mesenchymal stem cells (MSCs) possess, in addition to their cell progenitor function, a secretory capacity based on cooperativity wi… Show more

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Cited by 65 publications
(68 citation statements)
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“…This preferential homing of breast cancer cells was recently observed using real‐time in vivo microscopy in which DTCs home to E‐selectin‐ and CXCL12‐rich perivascular regions . Similarly, disseminated melanoma cancer cells interact with MSCs through CD146 (also known as melanoma cell adhesion molecule [MCAM]) and CXCR4 to facilitate their colonization . Although the perivascular niche also contains resident stem cells, direct competition of tumor cells for niche occupancy has not been reported.…”
Section: Pre‐existing Niches and Bone Colonizationmentioning
confidence: 88%
“…This preferential homing of breast cancer cells was recently observed using real‐time in vivo microscopy in which DTCs home to E‐selectin‐ and CXCL12‐rich perivascular regions . Similarly, disseminated melanoma cancer cells interact with MSCs through CD146 (also known as melanoma cell adhesion molecule [MCAM]) and CXCR4 to facilitate their colonization . Although the perivascular niche also contains resident stem cells, direct competition of tumor cells for niche occupancy has not been reported.…”
Section: Pre‐existing Niches and Bone Colonizationmentioning
confidence: 88%
“…For example, in the perivascular niche, extravasated cancer cells remain attached to the external vessel walls, seeking physical support 16,28 for recovery while remaining dormant 29 . Mesenchymal stem cells (MSCs), acting as pericytes surrounding the vasculature, aid this process 30 . The arriving DTCs further benefit from angiogenesis, lymphoangiogenesis 20 and vascular leakiness induced by primary tumour-secreted extracellular vesicles 31,32 or cytokines such as VEGF, which promotes endothelial FAK/Eselectin-mediated permeability 33 .…”
Section: Common Functions Of the Metastatic Nichesmentioning
confidence: 99%
“…The pericyte serves as gate-keepers for metastasizing tumor cells like those from melanoma. The CD146 antigen on both the pericyte and the melanoma play a crucial role in bringing the MSCs into the developing tumor to assist in tumor expansion (26). Dr. Justin Lathia (Cleveland Clinic, Cleveland, OH, USA) discussed that the interaction of CSCs with immune cells that results in immune suppression and tumor progression in GBM.…”
Section: Microenvironment Metabolism Inflammation and New Conceptsmentioning
confidence: 99%