Mesenchymal stem cells for the treatment of cognitive impairment caused by neurological diseases

Qu, Mingcui; Xing, Fei; Xing, Na

doi:10.1007/s10529-022-03274-7

Cited by 6 publications

(4 citation statements)

References 86 publications

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“…The transplantation of nasal olfactory mucosa MSCs showed benefits in the AD mouse model of Alzheimer's disease (AD) [188]. An exosomal microRNA (miR-146a) secreted from BM-MSCs is taken up into astrocytes [189]. Intracerebra-ventricularly injected BM-MSCs improve cognitive impairment by increasing the expression of miR-146a in the hippocampus [190].…”

Section: Effects In Regenerative Medicinementioning

confidence: 99%

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Bone Marrow: The Central Immune System

Schirrmacher¹

2023

Immuno

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Bone marrow is known as the site of hematopoiesis. What is not being described in textbooks of immunology is the fact that bone marrow is not only a generative, but also an antigen-responsive, immune organ. It is also a major storage site for antigen-specific memory B and T cells. That bone marrow is a priming site for T cell responses to blood borne antigens was discovered exactly 20 years ago. This review celebrates this important discovery. The review provides a number of examples of medical relevance of bone marrow as a central immune system, including cancer, microbial infections, autoimmune reactions, and bone marrow transplantation. Bone marrow mesenchymal stem cell-derived stromal cells provide distinct bone marrow niches for stem cells and immune cells. By transmitting anti-inflammatory dampening effects, facilitating wound healing and tissue regeneration mesenchymal stem cells contribute to homeostasis of bone and other tissues. Based on the evidence presented, the review proposes that bone marrow is a multifunctional and protective immune system. In an analogy to the central nervous system, it is suggested that bone marrow be designated as the central immune system.

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Section: Effects In Regenerative Medicinementioning

confidence: 99%

“…MSCs are likely able to cross the blood-brain barrier. Therefore, MSC-based therapy is regarded as an important means of ameliorating neurological impairment [187][188][189][190][191]. (iii) Lung injury and fibrosis: MSC-derived EVs attenuate radiation-induced lung injury via miRNA-214-3p [192].…”

Section: Effects In Regenerative Medicinementioning

confidence: 99%

Bone Marrow: The Central Immune System

Schirrmacher¹

2023

Immuno

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“…MSCs exhibit tropism to injury sites and secrete a diverse range of growth and neurotrophic factors, eliciting immunomodulatory and neuroprotective effects that promote neuronal survival and regeneration [ 11 , 12 ]. Therefore, MSC therapy could be considered a significant approach for ameliorating neurological dysfunction [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The safety profile of mesenchymal stem cell therapy administered through intrathecal injections for treating neurological disorders: a systematic review and meta-analysis of randomised controlled trials

Mesa Bedoya,

Camacho Barbosa,

López Quiceno

et al. 2024

Stem Cell Res Ther

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Background Based on previous in vivo studies and human trials, intrathecal cell delivery is a safe and relevant therapeutic tool for improving patient's quality of life with neurological conditions. We aimed to characterise the safety profile of intrathecally delivered Mesenchymal stem cells (MSCs). Methods Ovid MEDLINE, Embase, Scopus, Cochrane Library, KCI-Korean Journal Database, and Web of Science. Databases were searched from their inception until April 13, 2023. Randomised Controlled Trials (RCTs) that compared intrathecal delivery of MSCs to controls in adult populations were included. Adverse events (AEs) were pooled and meta-analysed using DerSimonian-Laird random effects models with a correction factor 0.5 added to studies with zero count cells. Pooled AEs were described using Risk ratio (RR) and 95% confidence intervals (95% CI). Then, a random-effects meta-regress model on study-level summary data was performed to explore the relationship between the occurrence of AEs and covariates thought to modify the overall effect estimate. Finally, publication bias was assessed. Results 303 records were reviewed, and nine RCTs met the inclusion criteria and were included in the quantitative synthesis (n = 540 patients). MSCs delivered intrathecally, as compared to controls, were associated with an increased probability of AEs of musculoskeletal and connective tissue disorders (categorised by Common Terminology Criteria for Adverse Events—CTCAE version 5.0) (RR: 1.61, 95% CI 1.19–2.19, I2 = 0%). The random-effects meta-regress model suggested that fresh MSCs increased the probability of occurrence of AEs compared to cryopreserved MSCs (RR: 1.554; p-value = 0.048; 95% CI 1.004–2.404), and the multiple-dose, decreased the probability of AEs by 36% compared to single doses (RR: 0.644; p-value = 0.048; 95% CI 0.416–0.996); however, univariate random effects meta-regression models revealed a not significant association between the occurrence of AEs from MSCs intrathecal delivery and each covariate. Conclusions Intrathecal delivery of MSCs was associated with a slight increase in AEs associated with musculoskeletal and connective tissue disorders, albeit without serious AEs. We conclude that intrathecal MSCs delivery is safe for patients with neurological conditions. However, further high-quality, large-scale RCTs are needed to confirm these findings.

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“…In cardiovascular medicine, MSCs have been investigated for their ability to improve cardiac function and promote blood vessel formation, holding the potential for treating heart failure and ischemic conditions [8]. Additionally, MSC-based therapies have shown encouraging results in neurological disorders, autoimmune diseases, and tissue injuries, demonstrating their versatility and potential to revolutionize patient care [9]. Due to these key characteristics, MSCs hold tremendous promise for regenerative medicine applications.…”

Section: Introductionmentioning

confidence: 99%

A closer look at Mesenchymal Stem cells (MSCs), their potential and function as game-changers of Modern Medicine

Ali Khodadoust,

Boroumand,

Sedaghat

et al. 2023

Recent Update on Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) have garnered significant attention in modern medicine as a potentially effective therapeutic intervention, owing to their distinctive characteristics, including the ability to self-renew, exhibit multipotency, elicit immunomodulatory effects, and promote tissue repair. MSCs are being studied extensively for their potential use in a wide range of clinical applications, including regenerative medicine, immunotherapy, and tissue engineering. In this chapter, we provide a comprehensive overview of the biology, potential, and function of MSCs, highlighting their role in modulating the immune system, promoting tissue repair, and restoring homeostasis in various disease conditions. We also discuss the challenges and limitations associated with MSC-based therapies, including issues related to their isolation, expansion, and delivery. Further research is needed to fully understand the mechanisms underlying MSCs’ therapeutic effects and to optimize their clinical application. Nevertheless, MSCs hold great promise as game-changers in modern medicine, and their potential to revolutionize the field of regenerative medicine and immunotherapy cannot be overlooked.

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Mesenchymal stem cells for the treatment of cognitive impairment caused by neurological diseases

Cited by 6 publications

References 86 publications

Bone Marrow: The Central Immune System

Bone Marrow: The Central Immune System

The safety profile of mesenchymal stem cell therapy administered through intrathecal injections for treating neurological disorders: a systematic review and meta-analysis of randomised controlled trials

A closer look at Mesenchymal Stem cells (MSCs), their potential and function as game-changers of Modern Medicine

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