Mesenchymal Stem Cells exposed to persistently high glucocorticoid levels develop insulin-resistance and altered lipolysis: a promising in vitro model to study Cushing's Syndrome
Abstract:Background: In Cushing's syndrome (CS), chronic glucocorticoid excess (GC) and disrupted circadian rhythm lead to insulin resistance (IR), diabetes mellitus, dyslipidaemia and cardiovascular comorbidities. As undifferentiated, self-renewing progenitors of adipocytes, mesenchymal stem cells (MSCs) may display the detrimental effects of excess GC, thus revealing a promising model to study the molecular mechanisms underlying the metabolic complications of CS.Methods: MSCs isolated from the abdominal skin of healt… Show more
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