Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors

Roger, Mathilde; Clavreul, Anne; Venier-Julienne, Marie-Claire; Passirani, Catherine; Sindji, Laurence; Schiller, Paul C.; Montero‐Menei, Claudia N.; Meneï, Philippe

doi:10.1016/j.biomaterials.2010.07.048

Cited by 212 publications

(143 citation statements)

References 55 publications

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“…Though, this technology offers significant release by the use of nanoparticles in vivo that has been demanding to the competent approval, ineffective distribution in solid tumors and unable to attack the micro metastatic lesions [184]. To defeat these barriers, the use of SCs as nanoparticles release agents that can travel to develop malignancies and to set down the overloaded nanoparticles that are related to the cancer [185,186].…”

Section: Nanoparticles Carrier Function Of Stem Cellsmentioning

confidence: 99%

Development of Anti-Cancer Stem Cells as Theranostic Agents in the Treatment of Different Cancer Types: An Update

Malik¹,

Rasool²,

Khan³

et al. 2017

J Carcinog Mutagen

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Various unprecedented anti-tumor potential targets that robustly target cancer cells while sparing normal cells have been produced by biomedical research in cancer therapeutic intervention for interrupting disease progression and their cure. Stem cells characterize an accessible cell source for novel cell based clinical therapies by inhibiting tumor progression signalling pathways. They carry distinctive characteristics of isolation and migration to tissue inflammation site, inherited modifiability and protein expression. Stem cells are also used in immune-reconstitution and tissue regeneration. Implication of different types of stem cells as an attractive candidate for targeted delivery of anti-neoplastic agents has emerged as a promising field in anticancer therapy. Mutual interaction between cancer cells and stem cells results in effective and safer clinical therapy for tumors. Keeping in view, this review highlights the potential role of stem cells in the progression of tumor metastasis and also summarizes the role of different signaling pathways in carcinogenesis and their involvement in disease treatment. It also focuses on the current advances in stem cells practice in therapeutics of cancer.

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Section: Nanoparticles Carrier Function Of Stem Cellsmentioning

confidence: 99%

Development of Anti-Cancer Stem Cells as Theranostic Agents in the Treatment of Different Cancer Types: An Update

Malik¹,

Rasool²,

Khan³

et al. 2017

J Carcinog Mutagen

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show abstract

“…4 The DNA probe was complementary to the highly repetitive human satellite III sequences located close to the centromeric region of the human Y-chromosome DYZ1 locus (CEPY) and was labeled with the SpectrumOrange fluorochrome (Vysis; Abbott Laboratories, Abbott Park, IL, USA). Cryosections were then analyzed under an Axioscope ® 2 fluorescence microscope.…”

Section: Fluorescence In Situ Hybridizationmentioning

confidence: 99%

“…4 In this work, we defined the optimal dose of Fc-diOHLNCs that MIAMI cells could carry without deleterious effects on viability for at least 7 days after their uptake. For this purpose, we had to take drug and LNC matrix component concentrations into account.…”

Section: Optimization and Quantification Of Fc-dioh Internalization Bmentioning

confidence: 99%

“…[4][5][6] In particular, we used a homogeneous and immature subpopulation of human MSCs called "marrow-isolated adult multilineage inducible" (MIAMI) cells. 7,8 These cells, which are easily obtained from the bone marrow of patients, possess a unique molecular phenotype and their populations can be repeatedly doubled for expansion purposes, without a loss of stem cell properties.…”

Section: Introductionmentioning

confidence: 99%

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Targeting and treatment of glioblastomas with human mesenchymal stem cells carrying ferrociphenol lipid nanocapsules

Clavreul¹,

Montagu²,

Lainé³

et al. 2015

IJN

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International audience

Recently developed drug delivery nanosystems, such as lipid nanocapsules (LNCs), hold great promise for the treatment of glioblastomas (GBs). In this study, we used a subpopulation of human mesenchymal stem cells, "marrow-isolated adult multilineage inducible" (MIAMI) cells, which have endogenous tumor-homing activity, to deliver LNCs containing an organometallic complex (ferrociphenol or Fc-diOH), in the orthotopic U87MG GB model. We determined the optimal dose of Fc-diOH-LNCs that can be carried by MIAMI cells and compared the efficacy of Fc-diOH-LNC-loaded MIAMI cells with that of the free-standing Fc-diOH-LNC system. We showed that MIAMI cells entrapped an optimal dose of about 20 pg Fc-diOH per cell, with no effect on cell viability or migration capacity. The survival of U87MG-bearing mice was longer after the intratumoral injection of Fc-diOH-LNC-loaded MIAMI cells than after the injection of Fc-diOH-LNCs alone. The greater effect of the Fc-diOH-LNC-loaded MIAMI cells may be accounted for by their peritumoral distribution and a longer residence time of the drug within the tumor. These results confirm the potential of combinations of stem cell therapy and nanotechnology to improve the local tissue distribution of anticancer drugs in GB.

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“…They showed efficient internalization of the NPs into MSCs that were able to migrate toward an experimental human glioma model. They suggested MSCs as potential cellular carriers for delivery of NPs into brain tumors (Roger et al, 2010). In 2011, A dual-targeting drug carrier (PAMAM-PEG-WGA-Tf) was developed based on the PEGylated fourth generation PAMAM dendrimer with Tf and wheat germ agglutinin (WGA) on the periphery and DOX loaded in the interior (He et al, 2011).…”

Section: Recent Advancements For Crossing Bbbmentioning

confidence: 99%

Blood-Brain Barrier and Effectiveness of Therapy Against Brain Tumors

Omidi¹,

Barar²

2012

Novel Therapeutic Concepts in Targeting Glioma

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Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors

Cited by 212 publications

References 55 publications

Development of Anti-Cancer Stem Cells as Theranostic Agents in the Treatment of Different Cancer Types: An Update

Development of Anti-Cancer Stem Cells as Theranostic Agents in the Treatment of Different Cancer Types: An Update

Targeting and treatment of glioblastomas with human mesenchymal stem cells carrying ferrociphenol lipid nanocapsules

Blood-Brain Barrier and Effectiveness of Therapy Against Brain Tumors

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