Mesenchymal stem cells as a multimodal treatment for nervous system diseases

Badyra, Bogna; Sułkowski, Maciej; Milczarek, Olga; Majka, Marcin

doi:10.1002/sctm.19-0430

Cited by 49 publications

(34 citation statements)

References 153 publications

(225 reference statements)

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“…Current studies have also proved that the administration of MSC promotes recovery from traumatic brain injury due to oxidative stress reduction [ 233 , 234 ], reduced mortality rates [ 235 ], and the size of the infarct area [ 236 ] after ischaemic stroke. In addition, MSC-based therapies represent an exciting neuroprotective and neuroregenerative strategy for spinal cord injuries [ 237 ], which are associated with tremendous physical, social, and financial costs for millions of individuals worldwide.…”

Section: New Horizons For Clinical Applications Of Mscmentioning

confidence: 99%

Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine

Fernández-Francos

Eiró

Costa

et al. 2021

IJMS

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Around 40% of the population will suffer at some point in their life a disease involving tissue loss or an inflammatory or autoimmune process that cannot be satisfactorily controlled with current therapies. An alternative for these processes is represented by stem cells and, especially, mesenchymal stem cells (MSC). Numerous preclinical studies have shown MSC to have therapeutic effects in different clinical conditions, probably due to their mesodermal origin. Thereby, MSC appear to play a central role in the control of a galaxy of intercellular signals of anti-inflammatory, regenerative, angiogenic, anti-fibrotic, anti-oxidative stress effects of anti-apoptotic, anti-tumor, or anti-microbial type. This concept forces us to return to the origin of natural physiological processes as a starting point to understand the evolution of MSC therapy in the field of regenerative medicine. These biological effects, demonstrated in countless preclinical studies, justify their first clinical applications, and draw a horizon of new therapeutic strategies. However, several limitations of MSC as cell therapy are recognized, such as safety issues, handling difficulties for therapeutic purposes, and high economic cost. For these reasons, there is an ongoing tendency to consider the use of MSC-derived secretome products as a therapeutic tool, since they reproduce the effects of their parent cells. However, it will be necessary to resolve key aspects, such as the choice of the ideal type of MSC according to their origin for each therapeutic indication and the implementation of new standardized production strategies. Therefore, stem cell science based on an intelligently designed production of MSC and or their derivative products will be able to advance towards an innovative and more personalized medical biotechnology.

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Section: New Horizons For Clinical Applications Of Mscmentioning

confidence: 99%

Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine

Fernández-Francos

Eiró

Costa

et al. 2021

IJMS

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“…In clinical trials utilizing MSC for spinal cord injury, stroke or traumatic brain injury side effects related to the procedure noted, although none of them were followed with sequelae. Transplantation of MSCs resulted in neurologic improvement in the majority of clinical trials, with superior performance in motor function, sensory level and daily living activities [ 189 ]. MSCs have great potential to improve patient symptoms and quality of life, whereas traditional medicine offers no efficient treatment.…”

Section: Mscs-based Therapies For Multiple Organs Affected By Covid-1mentioning

confidence: 99%

Therapeutic potential of mesenchymal stem cells in multiple organs affected by COVID-19

et al. 2021

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Currently, the world has been devastated by an unprecedented pandemic in this century. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the agent of coronavirus disease 2019 (COVID-19), has been causing disorders, dysfunction and morphophysiological alterations in multiple organs as the disease evolves. There is a great scientific community effort to obtain a therapy capable of reaching the multiple affected organs in order to contribute for tissue repair and regeneration. In this regard, mesenchymal stem cells (MSCs) have emerged as potential candidates concerning the promotion of beneficial actions at different stages of COVID-19. MSCs are promising due to the observed therapeutic effects in respiratory preclinical models, as well as in cardiac, vascular, renal and nervous system models. Their immunomodulatory properties and secretion of paracrine mediators, such as cytokines, chemokines, growth factors and extracellular vesicles allow for long range tissue modulation and, particularly, blood-brain barrier crossing. This review focuses on SARS-CoV-2 impact to lungs, kidneys, heart, vasculature and central nervous system while discussing promising MSC's therapeutic mechanisms in each tissue. In addition, MSC's therapeutic effects in high-risk groups for COVID-19, such as obese, diabetic and hypertensive patients are also explored.

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“…Additionally, BMSCs are pluripotent stem cells and have been proved to migrate to areas afflicted by neurological insults or neurodegeneration ( Borlongan et al, 2011 ). When compared with other types of bone marrow-derived cells, BMSCs have been widely studied because of their availability, ease of isolation and culture, powerful self-renewal, and multilineage differentiation ( Grove et al, 2004 ; Badyra et al, 2020 ). The possible mechanism by which BMSCs act on brain tissue can be summarized as follows ( Figure 2 ): (1) BMSCs could migrate to the injured brain areas via passing through the BBB with the help of several receptors, integrins, selectins and proteolytic enzymes.…”

Section: Impact Of Bone-derived Modulators On the Brainmentioning

confidence: 99%

Bone-Derived Modulators That Regulate Brain Function: Emerging Therapeutic Targets for Neurological Disorders

Chen

Shang

Wen

et al. 2021

Front. Cell Dev. Biol.

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Bone has traditionally been regarded as a structural organ that supports and protects the various organs of the body. Recent studies suggest that bone also acts as an endocrine organ to regulate whole-body metabolism. Particularly, homeostasis of the bone is shown to be necessary for brain development and function. Abnormal bone metabolism is associated with the onset and progression of neurological disorders. Recently, multiple bone-derived modulators have been shown to participate in brain function and neurological disorders, including osteocalcin, lipocalin 2, and osteopontin, as have bone marrow-derived cells such as mesenchymal stem cells, hematopoietic stem cells, and microglia-like cells. This review summarizes current findings regarding the roles of these bone-derived modulators in the brain, and also follows their involvement in the pathogenesis of neurological disorders. The content of this review may aide in the development of promising therapeutic strategies for neurological disorders via targeting bone.

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Mesenchymal stem cells as a multimodal treatment for nervous system diseases

Cited by 49 publications

References 153 publications

Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine

Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine

Therapeutic potential of mesenchymal stem cells in multiple organs affected by COVID-19

Bone-Derived Modulators That Regulate Brain Function: Emerging Therapeutic Targets for Neurological Disorders

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