2016
DOI: 10.2741/4380
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Mesenchymal stem cells and their relationship to pericytes

Abstract: Our body contains cells that can be propagated in vitro and give rise to cells with mature mesenchymal phenotypes. These cells are interesting not only because of their differentiation capability, which could be used for tissue engineering, but also because they secrete molecules which have trophic, chemoattractant, and immunomodulatory properties. Along decades of study, these cells have been referred to as fibroblastic cells, stromal cells, or mesenchymal stem cells. There is evidence that pericytes, cells t… Show more

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Cited by 37 publications
(21 citation statements)
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References 155 publications
(177 reference statements)
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“…Various types of evidence suggest that pericytes behave as mesenchymal stem cells in different tissues [83], including the liver [84]. Pericytes, including HSCs, have been shown to give rise to cultured mesenchymal stromal cells (MSCs) [85][86][87], which are able to differentiate into bone, cartilage, and fat cells in vitro and secrete a number of paracrine molecules that have trophic and immunomodulatory properties [88].…”
Section: Hypothesis: Activated Hscs Resemble Mesenchymal Stromal Cellmentioning
confidence: 99%
“…Various types of evidence suggest that pericytes behave as mesenchymal stem cells in different tissues [83], including the liver [84]. Pericytes, including HSCs, have been shown to give rise to cultured mesenchymal stromal cells (MSCs) [85][86][87], which are able to differentiate into bone, cartilage, and fat cells in vitro and secrete a number of paracrine molecules that have trophic and immunomodulatory properties [88].…”
Section: Hypothesis: Activated Hscs Resemble Mesenchymal Stromal Cellmentioning
confidence: 99%
“…PDGFRβ is a cell‐surface tyrosine‐kinase receptor that occurs as a homodimer or heterodimer (Shim et al, ). PDGFRβ and its ligands PDGF‐B and PDGF‐D play critical roles in the migration and proliferation of mesenchymal cells (Heldin et al, ; Sano et al, ), which were recently proposed to derive from pericytes under certain conditions (da Silva Meirelles et al, ). As PDGFRβ locates in pericytes and its ligand PDGF‐B is in endothelial cells, the PDGFRβ/PDGF‐B interaction could be a critical molecular pathway for pericyte–endothelial cell communication during vascularization and proper formation of the blood–brain barrier (BBB) (Gerhardt and Betsholtz, ; Hellström et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…To study the role of perivascular cells in regulating barrier function, we used a microfluidic device in which human bone marrow stromal cells (hBMSCs), a cell population that exhibit mural cell characteristics (23)(24)(25)(26)(27)(28), lined a perfusable endothelialized channel. The device was assembled based largely on previously described models of endothelialized channels (29), in this case by casting a single, hollowed cylindrical channel (160 μm diameter) into type-I collagen within a polydimethylsiloxane (PDMS) mold containing a bulk chamber hosting the vessel and reservoir chambers for introducing media into the system.…”
Section: Bicellular Perfusable 3d Platform Recapitulates Pericyte Rolmentioning
confidence: 99%