2015
DOI: 10.1021/acsnano.5b02207
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Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy

Abstract: Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging. We demonstrate that mesenchymal stem cells (MSCs) can aggregate pH-sensitive gold nanoparticles (PSAuNPs) in mildly acidic endosomes, target tumors, and be used for photothermal therapy. These aggregated structures… Show more

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Cited by 160 publications
(126 citation statements)
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References 47 publications
(107 reference statements)
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“…Noticeably, the MHR of the enriched cells, typically 1400°C s −1 M −1 , is roughly 7-fold that of ChAumix in colloidal solution. This result is in agreement with the observation that closely packed nanoparticles behaves as improved heat generators [28], which can also explain the good heating performances found by Kang et alii [29], obtained by aggregating spherical nanoparticles via pH-induced modification of the nanoparticles surface electrical charge. In that case, from the data presented, a cellular MHR of 1190°C s −1 M −1 can be inferred, quite close to the MHR calculated for ECFCs.…”
Section: Resultssupporting
confidence: 91%
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“…Noticeably, the MHR of the enriched cells, typically 1400°C s −1 M −1 , is roughly 7-fold that of ChAumix in colloidal solution. This result is in agreement with the observation that closely packed nanoparticles behaves as improved heat generators [28], which can also explain the good heating performances found by Kang et alii [29], obtained by aggregating spherical nanoparticles via pH-induced modification of the nanoparticles surface electrical charge. In that case, from the data presented, a cellular MHR of 1190°C s −1 M −1 can be inferred, quite close to the MHR calculated for ECFCs.…”
Section: Resultssupporting
confidence: 91%
“…As a final remark, if from one side the presence of broadly dispersed ChAumix limits the absorption at a given excitation wavelength to a restricted number of tuned particles, on the other side the absorbance remains higher than the 90% of the maximum value in a wide band (~ 100 nm), and thus may comply more easily with laser users, hopefully in hospital. We measured Au loadings as high as 220 pg/cell, a cell enrichment that, at our knowledge, has not been reached so far [2, 29, 32]. This is due to the high efficiency of the enriching process, likely driven by the attractive forces between positively charged Au nanoparticles and negatively charged cells membranes in agreement with the observations reported by M. Pérez-Hernández [35].…”
Section: Discussionsupporting
confidence: 86%
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“…Hypoxic‐treated neural stem cells showed the overexpression of CXCR4 and could enhance the tumor migration ability 23. There were numerous studies utilized the homing ability of stem cells for tumor targeting 24, 25, 26, 27, 28. In addition, it has been reported that iron oxide nanoparticles with the released iron ions could increase the CXCR4 expression on the mesenchymal stem cell (MSC) surface and promote the migration ability 29.…”
Section: Introductionmentioning
confidence: 99%
“…This therapeutic approach is extremely promising and for this reason is under extensive preclinical and clinical investigations for the treatment of various medical conditions, including cancer. 19,20 The current understanding of the relationship between optical properties of the NIR-emitting NPs, NP heating efficiency, and their applicative potential in the medical field as theranostic probes is limited. In this context, in the present study, we evaluated both the PA and fluorescence capabilities of dye-doped NIR-pluronic-silica NPs (NIR-PluS NPs), which display a tunable intensity profile across the NIR spectrum.…”
mentioning
confidence: 99%