Mesenchymal stem cells – A new hope for radiotherapy-induced tissue damage?

Nicolay, Nils H.; Perez, Ramon Lopez; Debus, Jürgen; Huber, Peter E.

doi:10.1016/j.canlet.2015.06.012

Cited by 95 publications

(85 citation statements)

References 130 publications

(141 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were increased levels of IL-10, VEGF, b-FGF, and EGF. Histopathological studies showed improved intestinal epithelial homeostasis that might be owing to MSCs overexpressing stromal cell-derived factor receptor CXCR-4 [71]. All these data support the homing and the paracrine mechanism of action rather that the regenerative and multipotent differentiation mechanism of action [71].…”

Section: Mscs Mechanism Of Action In Rormmentioning

confidence: 81%

“…These findings suggest that the paracrine and the anti-inflammatory effect of MSCs is the expected radio-protective mechanism of action of MSCs in RORM rather than the differentiation to a specific cell type [71].…”

Section: Mscs Mechanism Of Action In Rormmentioning

confidence: 87%

“…Chk1 phosphorylates Cdc25 in the presence of DNA damage resulting in the inhibition of Cdc25 activity. Chk1 and Chk2 are main inhibitors of Cdc25A and Cdc25C resulting in Cdk/cyclin-mediated cell cycle arrest [71]. It has been suggested that DSB in MSCs are repaired by activation of both the homologous recombination (HR, during S and G2 phases) and the non-homologous end-joining (NHEJ, during all cell cycle phases) DNA repair pathways [95,104,106].…”

Section: Mesenchymal Stromal Cells (Mscs) Radio-biological Responsementioning

confidence: 99%

“…[71,89] aMSCs = adipose-derived mesenchymal stromal cell, bmMSC = bone marrow MSCs; BBB = blood brain barrier; BM = bone marrow; CNS = central nervous system; EPC = endothelial progenitor cells; GFAP = glial fibrillary acidic protein; hESC = human embryonic stem cell; hSC = human stem cells; hNSC = human neural stem cell, RT = radiation.…”

Section: Liver Tissue Protectionmentioning

confidence: 99%

“…Also, MSCs have some agiogenic properties evident by increased secretion of (platelets derived growth factor) PDGF, VEGF and TGF-β at the tumor perivascular area and parenchyma in low dose irradiated mice owing to MSCs infiltration at the tumor site [53]. MSCs angiogenic properties might counteract the anti-angiogenic cancer therapies, a question that needs to be answered with solid in-vitro and in-vivo studies [71,104].…”

Section: Challenges Facing Mscs Therapymentioning

confidence: 99%

See 4 more Smart Citations

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

et al. 2016

View full text Add to dashboard Cite

Section: Mscs Mechanism Of Action In Rormmentioning

confidence: 81%

Section: Mscs Mechanism Of Action In Rormmentioning

confidence: 87%

Section: Mesenchymal Stromal Cells (Mscs) Radio-biological Responsementioning

confidence: 99%

Section: Liver Tissue Protectionmentioning

confidence: 99%

Section: Challenges Facing Mscs Therapymentioning

confidence: 99%

See 3 more Smart Citations

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

et al. 2016

View full text Add to dashboard Cite

Radiation‐induced sensitivity of tissue‐resident mesenchymal stem cells in the head and neck region

Spiegel¹,

Hambrecht²,

Kohlbauer³

et al. 2019

Head & Neck

View full text Add to dashboard Cite

Background Tissue‐resident mesenchymal stem cells (MSCs) possess the ability to migrate to areas of inflammation and promote the regeneration of damaged tissue. However, it remains unclear how radiation influences this capacity of MSC in the head and neck region. Methods Two types of MSCs of the head and neck region (mucosa [mMSC] and parotid gland [pMSC]) were isolated, cultured and exposed to single radiation dosages of 2 Gy/day up to 10 days. Effects on morphology, colony forming ability, apoptosis, chemokine receptor expression, cytokine secretion, and cell migration were analyzed. Results Although MSC preserved MSC‐specific regenerative abilities and immunomodulatory properties following irradiation in our in vitro model, we found a deleterious impact on colony forming ability, especially in pMSC. Conclusions MSC exhibited robustness and activation upon radiation for the support of tissue regeneration, but lost their potential to replicate, thus possibly leading to depletion of the local MSC‐pool after irradiation

show abstract

Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies

Lyu

Zhang

et al. 2020

Hematological Oncology

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) are a subset of multifunctional stem cells with self‐renewal and multidirectional differentiation properties that play a pivotal role in tumor progression. MSCs are reported to exert biological functions by secreting specialized vesicles, known as exosomes, with tumor cells. Exosomes participate in material and information exchange between cells and are crucial in multiple physiological and pathological processes. This study provides a comprehensive overview of the roles, mechanisms of action and sources of MSC exosomes in hematological malignancies, and different tumor types.

show abstract

Mesenchymal stem cells – A new hope for radiotherapy-induced tissue damage?

Cited by 95 publications

References 130 publications

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

Radiation‐induced sensitivity of tissue‐resident mesenchymal stem cells in the head and neck region

Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies

Contact Info

Product

Resources

About