Mesenchymal stem cell-tumor cell cooperation in breast cancer vasculogenesis

Comşa, Şerban; Ciuculescu, Felicia; Raica, Marius

doi:10.3892/mmr.2012.796

Cited by 17 publications

(15 citation statements)

References 15 publications

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“…Biomicroscopy image analysis of control CAM at day 17 showed a typical hierarchical organization of the vascular tree, whereas VEGF perturbed this defined architecture by inducing new capillaries, which emerge out of arterioles, venules, and existing capillaries (17). However, in a previous in vitro model, we demonstrated that hMSC developed long and thin branches interconnecting each other and had a clear tendency to organize in clusters and to form capillary-like structures following exposure to VEGF (18), so that we cannot totally exclude VEGF out of the vasculogenic pathway. It remains to determine the panel of mechanisms activated by hMSC in the CAM nonembryonic vasculogenesis and to evaluate the level of the VEGF involvement in this process.…”

Section: Discussionmentioning

confidence: 89%

The Human Mesenchymal Stem Cells and the Chick Embryo Chorioallantoic Membrane: The Key and the Lock in Revealing Vasculogenesis

Comşa

Ceauşu

Popescu

et al. 2017

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Section: Discussionmentioning

confidence: 89%

The Human Mesenchymal Stem Cells and the Chick Embryo Chorioallantoic Membrane: The Key and the Lock in Revealing Vasculogenesis

Comşa

Ceauşu

Popescu

et al. 2017

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“…It appears that tumors may actually take this a bit further, in that MSCs demonstrate a tendency to organize in clusters and to form capillary-like structures, in the presence of cancer cells (e.g. MCF-7 breast cancer cell line) [8]. Furthermore, MSCs secrete various factors that not only attract vasculogenic cells, such as vascular endothelial cells, but also increase their survival and inhibit apoptosis.…”

Section: Angiogenesismentioning

confidence: 99%

Involvement of Mesenchymal Stem Cells in Cancer Progression and Metastases

Chang¹,

Schwertschkow²,

Nolta³

et al. 2015

CCDT

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Mesenchymal stem/stromal cells (MSCs) are known to be the helpers for the healing of tissue damage, often referred to as ambulatory cells. However, MSCs are also recruited by cancer cells to similarly aid in tumor growth and progression. In this review, some of the key steps in cancer progression and metastases are described including the various steps in which MSCs participate and may play important roles. MSCs aid in cancer cells' ability to evade immune attack, while promoting tumor angiogenesis, even being counter-acting against chemotherapeutics and other drugs used to fight various cancers. Furthermore, MSCs participate in many of the crucial steps in invasion and metastasis, including stimulating the epithelial-mesenchymal transition (EMT) and induction of stem-like properties that allow cancer stem cells to increase their survivability through the circulation. These steps are described in detail. Differences between circulating tumor cells (CTCs) and cancer stem cells (CSCs) are discussed, along with descriptions of the formation of a pre-metastatic niche, the role of exosomes from both cancer cells and MSCs in metastasis and tumor reseeding (self-seeding). More and more, MSCs are being proposed as a promising tumor targeting drug-delivery tool. In order to fulfill this promise, further understanding of the precise roles that MSCs play in the process of cancer metastases must be achieved, in attempting to create remedies that will improve the outcome of available therapeutics.

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“…Despite the attractiveness of MSCs for cell therapy, one has to be mindful that MSCs can also support cancer growth as well as protect the cancer cells through immune suppression. [6][7][8][9][10][11][12][13][14][15] The translation of MSCs would need to consider the heterogeneity among cancer cells, as each subset might interact differently with MSCs. 16 Although the outcomes on the interaction between MSCs and cancer subsets are studied, research must continue to investigate the therapeutic potential of MSCs.…”

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confidence: 99%

Pollen‐induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis

Desai

Гаврилова

et al. 2013

Clin & Trans Imm

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Mesenchymal stem cells (MSCs) are promising cellular suppressor of inflammation. This function of MSCs is partly due to their licensing by inflammatory mediators. In cases with reduced inflammation, MSCs could become immune-enhancer cells. MSCs can suppress the inflammatory response of antigen-challenged lymphocytes from allergic asthma. Although allergic rhinitis (AR) is also an inflammatory response, it is unclear if MSCs can exert similar suppression. This study investigated the immune effects (suppressor vs enhancer) of MSCs on allergen-stimulated lymphocytes from AR subjects (grass or weed allergy). In contrast to subjects with allergic asthma, MSCs caused a significant (P<0.05) increase in the proliferation of antigen-challenged lymphocytes from AR subjects. The increase in lymphocyte proliferation was caused by the MSCs presenting the allergens to CD4+ T cells (antigen-presenting cells (APCs)). This correlated with increased production of inflammatory cytokines from T cells, and increased expressions of major histocompatibility complex (MHC)-II and CD86 on MSCs. The specificity of APC function was demonstrated in APC assay using MSCs that were knocked down for the master regulator of MHC-II transcription, CIITA. The difference in the effects of MSCs on allergic asthma and AR could not be explained by the sensitivity to the allergen, based on skin tests. Thus, we deduced that the contrasting immune effects of MSCs for antigen-challenged lymphocytes on AR and allergic asthma could be disease specific. It is possible that the enhanced inflammation from asthma might be required to license the MSCs to become suppressor cells. This study underscores the need for robust preclinical studies to effectively translate MSCs for any inflammatory disorder.

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Mesenchymal stem cell-tumor cell cooperation in breast cancer vasculogenesis

Cited by 17 publications

References 15 publications

The Human Mesenchymal Stem Cells and the Chick Embryo Chorioallantoic Membrane: The Key and the Lock in Revealing Vasculogenesis

The Human Mesenchymal Stem Cells and the Chick Embryo Chorioallantoic Membrane: The Key and the Lock in Revealing Vasculogenesis

Involvement of Mesenchymal Stem Cells in Cancer Progression and Metastases

Pollen‐induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis

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