Mesenchymal Stem Cell Transplantation: Neuroprotection and Nerve Regeneration After Spinal Cord Injury

Chen, Si-Yu; Yang, Rui-Lin; Wu, Xiang-Chong; Zhao, De-Zhi; Fu, Sheng-Ping; Lin, Feng-Qin; Li, Lin-Yan; Yu, Li-Mei; Zhang, Qian; Zhang, Tao

doi:10.2147/jir.s428425

Cited by 4 publications

(2 citation statements)

References 156 publications

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“…TGF-β induces the expression of CSPGs through activation of the PI3K/AKT pathway. Inhibition of TGF-β reduces glial scar formation after CNS injury ( Chen et al, 2023 ). In general, activation of the PI3K/AKT signaling pathway promotes the proliferation of spinal cord astrocytes, whereas inhibition of this pathway reduces the formation of glial scars and promotes recovery after SCI ( He et al, 2022 ).…”

Section: Pathophysiological Process Of Scimentioning

confidence: 99%

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Gao,

Wang,

et al. 2024

Front. Cell. Neurosci.

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Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, and autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, and chronic. In each period there are different alterations in the cells, inflammatory factors, and signaling pathways within the spinal cord. Many biomaterials have been investigated in the treatment of SCI, including hydrogels and fiber scaffolds, and some progress has been made in the treatment of SCI using multiple materials. However, there are limitations when using individual biomaterials in SCI treatment, and these limitations can be significantly improved by combining treatments with stem cells. In order to better understand SCI and to investigate new strategies for its treatment, several combination therapies that include materials combined with cells, drugs, cytokines, etc. are summarized in the current review.

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Section: Pathophysiological Process Of Scimentioning

confidence: 99%

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Gao,

Wang,

et al. 2024

Front. Cell. Neurosci.

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“…Secondly, MSCs can secrete extracellular vesicles (EVs), such as exosomes, containing biomolecules that similarly modulate the action of immune cells [14], among other multiple signaling effects. The anti-inflammatory and immunosuppressive abilities of MSCs may be beneficial in certain pathologies, such as spinal cord injuries, where their administration could stimulate neuroprotection in the injured area [15,16].…”

Section: Properties and Main Sources Of Mscsmentioning

confidence: 99%

Current Advances in Mesenchymal Stem Cell Therapies Applied to Wounds and Skin, Eye, and Neuromuscular Diseases in Companion Animals

Picazo,

Rojo,

Rodriguez-Quiros

et al. 2024

Animals

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Mesenchymal stem cells (MSCs) are considered a very promising alternative tool in cell therapies and regenerative medicine due to their ease of obtaining from various tissues and their ability to differentiate into different cell types. This manuscript provides a review of current knowledge on the use of MSC-based therapies as an alternative for certain common pathologies in dogs and cats where conventional treatments are ineffective. The aim of this review is to assist clinical veterinarians in making decisions about the suitability of each protocol from a clinical perspective, rather than focusing solely on research. MSC-based therapies have shown promising results in certain pathologies, such as spinal cord injuries, wounds, and skin and eye diseases. However, the effectiveness of these cell therapies can be influenced by a wide array of factors, leading to varying outcomes. Future research will focus on designing protocols and methodologies that allow more precise and effective MSC treatments for each case.

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Stem cell therapies for neurological disorders: current progress, challenges, and future perspectives

Rahimi Darehbagh,

Seyedoshohadaei,

Ramezani

et al. 2024

Eur J Med Res

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Stem cell-based therapies have emerged as a promising approach for treating various neurological disorders by harnessing the regenerative potential of stem cells to restore damaged neural tissue and circuitry. This comprehensive review provides an in-depth analysis of the current state of stem cell applications in primary neurological conditions, including Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, spinal cord injury (SCI), and other related disorders. The review begins with a detailed introduction to stem cell biology, discussing the types, sources, and mechanisms of action of stem cells in neurological therapies. It then critically examines the preclinical evidence from animal models and early human trials investigating the safety, feasibility, and efficacy of different stem cell types, such as embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs). While ESCs have been studied extensively in preclinical models, clinical trials have primarily focused on adult stem cells such as MSCs and NSCs, as well as iPSCs and their derivatives. We critically assess the current state of research for each cell type, highlighting their potential applications and limitations in different neurological conditions. The review synthesizes key findings from recent, high-quality studies for each neurological condition, discussing cell manufacturing, delivery methods, and therapeutic outcomes. While the potential of stem cells to replace lost neurons and directly reconstruct neural circuits is highlighted, the review emphasizes the critical role of paracrine and immunomodulatory mechanisms in mediating the therapeutic effects of stem cells in most neurological disorders. The article also explores the challenges and limitations associated with translating stem cell therapies into clinical practice, including issues related to cell sourcing, scalability, safety, and regulatory considerations. Furthermore, it discusses future directions and opportunities for advancing stem cell-based treatments, such as gene editing, biomaterials, personalized iPSC-derived therapies, and novel delivery strategies. The review concludes by emphasizing the transformative potential of stem cell therapies in revolutionizing the treatment of neurological disorders while acknowledging the need for rigorous clinical trials, standardized protocols, and multidisciplinary collaboration to realize their full therapeutic promise.

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Mesenchymal Stem Cell Transplantation: Neuroprotection and Nerve Regeneration After Spinal Cord Injury

Cited by 4 publications

References 156 publications

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Current Advances in Mesenchymal Stem Cell Therapies Applied to Wounds and Skin, Eye, and Neuromuscular Diseases in Companion Animals

Stem cell therapies for neurological disorders: current progress, challenges, and future perspectives

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