Abstract:Full-thickness cartilage injuries when left alone would increase the risk of osteoarthritis (OA) with severe associated pain and functional disability. The capability of the mesenchymal stem cells (MSCs) to repair and regenerate cartilage has been widely investigated. Articular cartilage defect may result from direct trauma or chronic degeneration. The subchondral bone plays an important role in healing through the presence of mesenchymal elements. MSCs are the most representative adult stem cells. It was obse… Show more
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