Mesenchymal Stem Cell Therapy for Sports Injuries - From Research to Clinical Practice

Looi, Qi Hao; Eng, Sue Ping; Liau, Ling Ling; Tor, Yin Sim; Bajuri, Mohd Yazid; Ng, Min Hwei; Law, Jia Xian

doi:10.17576/jsm-2020-4904-12

Cited by 17 publications

(12 citation statements)

References 18 publications

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“…They capture mesenchymal stem cells (MSCs) to heal both chondral and OCL in the knee and ankle. The MSCs secrete paracrine factors which modulate the immune response of the host, facilitate angiogenesis, improve cell migration and survival, and prevent fibrosis [11]. Once instilled, it keeps supporting MSC attachment, proliferation, and differentiation that will plug the lesion with new cartilage.…”

Section: Discussionmentioning

confidence: 99%

Osteochondral Injury of the Talus Treated With Cell-Free Hyaluronic Acid-Based Scaffold (Hyalofast®) – A Reliable Solution

Bajuri¹,

Sabri²,

Mazli³

et al. 2021

Cureus

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Section: Discussionmentioning

confidence: 99%

Osteochondral Injury of the Talus Treated With Cell-Free Hyaluronic Acid-Based Scaffold (Hyalofast®) – A Reliable Solution

Bajuri¹,

Sabri²,

Mazli³

et al. 2021

Cureus

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“…MSCs have self-renewal, differentiation, anti-apoptotic, anti-fibrotic, pro-mitotic, anti-oxidative, and immunomodulatory properties. [86][87][88] Besides, MSCs can be harvested from many tissue sources using minimally invasive techniques. 89 MSCs can also be expanded easily for many passages without significant changes in characteristics and functionality, and produce more exosomes.…”

Section: Source Of Exosomesmentioning

confidence: 99%

Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review

Ng¹,

Chai²,

Foo³

et al. 2021

IJN

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Treatment of cartilage defects such as osteoarthritis (OA) and osteochondral defect (OCD) remains a huge clinical challenge in orthopedics. OA is one of the most common chronic health conditions and is mainly characterized by the degeneration of articular cartilage, shown in the limited capacity for intrinsic repair. OCD refers to the focal defects affecting cartilage and the underlying bone. The current OA and OCD management modalities focus on symptom control and on improving joint functionality and the patient’s quality of life. Cell-based therapy has been evaluated for managing OA and OCD, and its chondroprotective efficacy is recognized mainly through paracrine action. Hence, there is growing interest in exploiting extracellular vesicles to induce cartilage regeneration. In this review, we explore the in vivo evidence of exosomes on cartilage regeneration. A total of 29 in vivo studies from the PubMed and Scopus databases were identified and analyzed. The studies reported promising results in terms of in vivo exosome delivery and uptake; improved cartilage morphological, histological, and biochemical outcomes; enhanced subchondral bone regeneration; and improved pain behavior following exosome treatment. In addition, exosome therapy is safe, as the included studies documented no significant complications. Modifying exosomal cargos further increased the cartilage and subchondral bone regeneration capacity of exosomes. We conclude that exosome administration is a potent cell-free therapy for alleviating OA and OCD. However, additional studies are needed to confirm the therapeutic potential of exosomes and to identify the standard protocol for exosome-based therapy in OA and OCD management.

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“…Mesenchymal stem cells (MSCs) are multipotent progenitor cells that can be isolated from the bone marrow, adipose tissue, dental tissues, skin, salivary gland, limb buds, menstrual blood, and perinatal tissues [ 26 , 27 , 28 , 29 ]. MSCs can differentiate into adipocytes, osteoblasts, and chondrocytes.…”

Section: Introductionmentioning

confidence: 99%

Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System

Yeo

Nordin

et al. 2021

IJMS

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Rapid growth of the geriatric population has been made possible with advancements in pharmaceutical and health sciences. Hence, age-associated diseases are becoming more common. Aging encompasses deterioration of the immune system, known as immunosenescence. Dysregulation of the immune cell production, differentiation, and functioning lead to a chronic subclinical inflammatory state termed inflammaging. The hallmarks of the aging immune system are decreased naïve cells, increased memory cells, and increased serum levels of pro-inflammatory cytokines. Mesenchymal stem cell (MSC) transplantation is a promising solution to halt immunosenescence as the cells have excellent immunomodulatory functions and low immunogenicity. This review compiles the present knowledge of the causes and changes of the aging immune system and the potential of MSC transplantation as a regenerative therapy for immunosenescence.

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Mesenchymal Stem Cell Therapy for Sports Injuries - From Research to Clinical Practice

Cited by 17 publications

References 18 publications

Osteochondral Injury of the Talus Treated With Cell-Free Hyaluronic Acid-Based Scaffold (Hyalofast®) – A Reliable Solution

Osteochondral Injury of the Talus Treated With Cell-Free Hyaluronic Acid-Based Scaffold (Hyalofast®) – A Reliable Solution

Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review

Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System

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