Mesenchymal stem cell therapy for laryngotracheal stenosis: A systematic review of preclinical studies

Jakobsen, Kathrine Kronberg; Grønhøj, Christian; Jensen, David Hebbelstrup; Fischer‐Nielsen, Anne; Hjuler, Thomas

doi:10.1371/journal.pone.0185283

Cited by 10 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another approach, a group of Russian researchers suggest the use of biotechnology for the treatment and prevention of the stenoses with tissue auto transplant and tissue engineering (tissue culture), with promising short-term results 16 , 17…”

Section: Discussionmentioning

confidence: 99%

Tracheal stenosis due to endotracheal tube cuff hyperinflation: a preventable complication

Gaspar

Maximiano²,

Minamoto³

et al. 2019

Autops. Case Rep.

View full text Add to dashboard Cite

Endotracheal intubation injuries are rare, but may be devastating—mostly among the pediatric patients or when these occur in the distal trachea. Such complications typify a therapeutic challenge, which, besides requiring intellectual and technical resources, takes a long time to reach a resolution. The authors present the case of a 15-year-old girl admitted with an abnormal state of consciousness due to diabetic ketoacidosis. She was submitted to endotracheal intubation with hyperinflation of the tube cuff, which rendered tracheal necrosis and detachment of the tracheal mucosa, and consequent obstruction. Later, she developed scarring retraction and stenosis. The patient was successfully treated with an endotracheal prosthesis insertion. The aim of this report is to illustrate a preventable complication.

show abstract

Section: Discussionmentioning

confidence: 99%

Tracheal stenosis due to endotracheal tube cuff hyperinflation: a preventable complication

Gaspar

Maximiano²,

Minamoto³

et al. 2019

Autops. Case Rep.

View full text Add to dashboard Cite

show abstract

“…Among laryngotracheal defects, laryngotracheal stenosis is the most often encountered case with considerable morbidity and mortality that happens congenitally or acquired after prolonged intubation and hypertrophic scarring, and is associated with narrowing of the airway at larynx, subglottis, or trachea [108]. Current choices in treatment of the stenosis are laser surgery, endoscopic dilation, laryngotracheal reconstruction, or life-long tracheostomy, but they can result in formation of new scar tissues and a further restenosis [108]. The regenerative medicine approach, by using MSCs and scaffolds, can represent a significant advantage over these limitations in otorhinolaryngology clinical practices [107].…”

Section: Larynx and Vocal Cord: Larynxmentioning

confidence: 99%

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Kaboodkhani

Mehrabani

Karimi‐Busheri

2021

JCM

View full text Add to dashboard Cite

Otorhinolaryngology enrolls head and neck surgery in various tissues such as ear, nose, and throat (ENT) that govern different activities such as hearing, breathing, smelling, production of vocal sounds, the balance, deglutition, facial animation, air filtration and humidification, and articulation during speech, while absence of these functions can lead to high morbidity and even mortality. Conventional therapies for head and neck damaged tissues include grafts, transplants, and artificial materials, but grafts have limited availability and cause morbidity in the donor site. To improve these limitations, regenerative medicine, as a novel and rapidly growing field, has opened a new therapeutic window in otorhinolaryngology by using cell transplantation to target the healing and replacement of injured tissues. There is a high risk of rejection and tumor formation for transplantation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs) lack these drawbacks. They have easy expansion and antiapoptotic properties with a wide range of healing and aesthetic functions that make them a novel candidate in otorhinolaryngology for craniofacial defects and diseases and hold immense promise for bone tissue healing; even the tissue sources and types of MSCs, the method of cell introduction and their preparation quality can influence the final outcome in the injured tissue. In this review, we demonstrated the anti-inflammatory and immunomodulatory properties of MSCs, from different sources, to be safely used for cell-based therapies in otorhinolaryngology, while their achievements and challenges have been described too.

show abstract

“…Several preclinical studies assessed the efficacy of MSC therapy for laryngotracheal stenosis [ 104 ]. Therapeutic benefit associated to MSC transplant is likely attributable to the secretion of soluble factors and to the release of extracellular vesicles (EVs) [ 22 ].…”

Section: Future Directionsmentioning

confidence: 99%

Regenerative medicine approaches for the management of respiratory tract fistulas

et al. 2020

View full text Add to dashboard Cite

Respiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic and the clinical presentation is heterogeneous. Respiratory tract fistulas can lead to severely reduced health-related quality of life and short survival. Therapy mainly relies on endoscopic surgical interventions but patients often require prolonged hospitalization and may develop complications. Therefore, more conservative regenerative medicine approaches, mainly based on lipotransfer, have also been investigated. Adipose tissue can be delivered either as unprocessed tissue, or after enzymatic treatment to derive the cellular stromal vascular fraction. In the current narrative review, we provide an overview of the main tissue/cell-based clinical studies for the management of various types of respiratory tract fistulas or injuries. Clinical experience is limited, as most of the studies were performed on a small number of patients. Albeit a conclusive proof of efficacy cannot be drawn, the reviewed studies suggest that grafting of adipose tissue-derived material may represent a minimally invasive and conservative treatment option, alternative to more aggressive surgical procedures. Knowledge on safety and tolerability acquired in prior studies can lead to the design of future, larger trials that may exploit innovative procedures for tissue processing to further improve the clinical outcome.

show abstract

Mesenchymal stem cell therapy for laryngotracheal stenosis: A systematic review of preclinical studies

Cited by 10 publications

References 25 publications

Tracheal stenosis due to endotracheal tube cuff hyperinflation: a preventable complication

Tracheal stenosis due to endotracheal tube cuff hyperinflation: a preventable complication

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Regenerative medicine approaches for the management of respiratory tract fistulas

Contact Info

Product

Resources

About