Mesenchymal Stem Cell Secretome: A Potential Tool for the Prevention of Muscle Degenerative Changes Associated with Chronic Rotator Cuff Tears

Abstract

Mesenchymal stem cell secretome decreases the characteristic muscle degeneration associated with chronic rotator cuff tears.

Adipose‐derived stem cells delay muscle atrophy after peripheral nerve injury in the rodent model

“…Oil Red O staining appeared to present less lipid accumulation in the cohorts having received ASC injections as shown in Figure . This is consistent with previous investigations suggesting that ASC secretome is capable of reducing lipid content in rotator cuff injuries . This finding however, is not consistent amongst the literature where injections of human vascular and adipose‐derived stem cells isolated from human stromal vascular fraction did not display significant changes in lipid reduction …”

“…This is consistent with previous investigations suggesting that ASC secretome is capable of reducing lipid content in rotator cuff injuries. 33 This finding however, is not consistent amongst the literature where injections of human vascular and adipose-derived stem cells isolated from human stromal vascular fraction did not display significant changes in lipid reduction. 34 Upon denervation, the local cellular environment of skeletal muscle becomes altered, where presence of inflammatory cells amongst the muscle fibers increases.…”

Pulsed Electromagnetic Fields Improve Tenogenic Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells: A Potential Strategy for Tendon Repair—An In Vitro Study

“…In the presence of local stem cell factories, a broader application of this concept may be envisioned as an off-the-shelf cell-free one-step therapy for tendon regeneration. The potential of this hypothesis has recently been suggested by Sevivas et al in preclinical models of rat rotator cuff tears [ 26 , 27 ]. These authors observed a decreased fatty degeneration and an increased muscular mass improved after local injection of human MSC secretome [ 26 ].…”

“…The potential of this hypothesis has recently been suggested by Sevivas et al in preclinical models of rat rotator cuff tears [ 26 , 27 ]. These authors observed a decreased fatty degeneration and an increased muscular mass improved after local injection of human MSC secretome [ 26 ]. The authors also noticed an anabolic effect of MSC secretome on human tendon cells in vitro and an improvement in enthesis reconstruction after implantation of the scaffolds seeded with human tendon cells pretreated with human MSC secretome [ 27 ].…”

Arthroscopic and open repair of massive rotator cuff tears have similar results: a systematic review

“…However, MRCTs are in fact very large tears that are difficult to repair and are often associated with an uncertain prognosis 15. Therefore, in order to assemble the greatest number of massive tears reported in different prospective studies, we included studies which reported the results of large-to-massive tears in the same group (minimum size of 3 cm) 30 31 33–36 38 39…”