Mesenchymal stem cell-mediated cancer therapy: A dual-targeted strategy of personalized medicine

Abstract

Cancer remains one of the leading causes of mortality and morbidity throughout the world. To a significant extent, current conventional cancer therapies are symptomatic and passive in nature. The major obstacle to the development of effective cancer therapy is believed to be the absence of sufficient specificity. Since the discovery of the tumor-oriented homing capacity of mesenchymal stem cells (MSCs), the application of specific anticancer gene-engineered MSCs has held great potential for cancer therapies. The dual-targeted strategy is based on MSCs' capacity of tumor-directed

TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells

“…Combined with the use of real-time detection of cytoxicity, the most effective anticancer genes can be identified from different anticancer gene-engineered MSCs within a short period of time. As outlined in our recent review, 42 the present study provides a useful platform toward the development of practically personalized therapy for cancer treatment. hpMSCs could serve as an allogeneic cell source when autologous MSCs are not available for MSC-mediated cancer therapy especially for the treatment of pancreatic cancer.…”

Review on Stem Cell Therapy and their Role in Cancer Treatment

“…In addition to their capability of multipotent differentiation, MSCs show many other therapeutically advantageous features such as easy acquisition, fast ex vivo expansion, the feasibility of autologous transplantation and a powerful paracrine function. More recently, the specific tumor-oriented migration and incorporation of MSCs have been demonstrated in various pre-clinical models revealing the potential for MSCs to be used as ideal vectors for delivering anticancer agents [1].…”

“…Since the discovery of the tumororiented homing capacity of mesenchymal stem cells (MSCs), the application of specific anticancer gene-engineered MSCs has held great potential for cancer therapies. With the discovery of specific anticancer genes and the revelation of MSCs' capacity of tumordirected migration and incorporation, a new research field has been inspired with the aim of achieving efficient therapy for cancer using engineered MSCs [1]. Therefore, the objectives of this manuscript are:…”

“…Current conventional cancer therapies such as surgery, chemotherapy and radiotherapy are symptomatic and passive in nature. The major limitation on the effectiveness of conventional therapies for cancer treatment is lack of tumor specificity [1]. In addition to the therapeutic specificity of anticancer agents, the development of drug resistance of tumor cells is another factor contributing to inefficient cancer therapy [4].…”

“…Cancer is one of the leading causes of mortality and morbidity throughout the world [1]. Over the past 50 years, many diseases that cause deaths have dramatically decreased but a cancer death has not been reduced [2].…”