Mesenchymal stem cell-like cells derived from human gastric cancer tissues

Xu, Wenrong; Qian, Hui; Zhu, Wei; Yan, Yongmin; Zhang, Hongxing; Zhang, Xu; Xu, Xuejing; Li, Jigang; Chen, Zhong; Xu, Xiaomeng

doi:10.1016/j.canlet.2008.08.036

Cited by 81 publications

(82 citation statements)

References 30 publications

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“…Such processes have been implicated in several aspects of epithelial tumor biology, such as tumor growth, neoplastic progression, angiogenesis, and metastasis [6,7]. MSCs have been isolated from different tumor types such as ovarian carcinomas [8], giant cell tumors of bone [9], neuroblastomas [10], osteosarcomas [11], lipomas [12], and gastric cancer [13]; however, the presence of MSCs in cervical cancer (CeCa) and their possible role in such tumor growth have not been documented.…”

Section: Introductionmentioning

confidence: 99%

“…the isolation of MSCs from several tumors [8][9][10][11][12][13]; however, the presence of MSCs has not been demonstrated in NCx or in CeCa tissue. Following this, and taking into consideration the immunossupressive properties of MSCs [35], we reasoned that the presence of these cells in cervical tumors may represent an important immunoselective advantage for tumor cells to evade the immune recognition.…”

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confidence: 99%

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In Vitro Evidence of the Presence of Mesenchymal Stromal Cells in Cervical Cancer and Their Role in Protecting Cancer Cells from Cytotoxic T Cell Activity

Montesinos

Mora‐García²,

Mayani

et al. 2013

Stem Cells and Development

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

In Vitro Evidence of the Presence of Mesenchymal Stromal Cells in Cervical Cancer and Their Role in Protecting Cancer Cells from Cytotoxic T Cell Activity

Montesinos

Mora‐García²,

Mayani

et al. 2013

Stem Cells and Development

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“…When bulk cancer cells are diminished by chemotherapy, CSCs are left in awkward situations without necessary nourishment, which may be sufficient for their extinction [133]. In addition, BMDCs and MSC-like cells recently isolated from GC and adjacent noncancerous tissues [95,136] may be the source of carcinoma-associated fibroblasts, which are suspected to promote tumor cell growth, and, along with MSCs, contribute to the CSC niche [137]. An in-depth understanding of in vitro/in vivo crosstalk between different cell types within the tumor milieu may give rise to improved anticancer strategies [137,138].…”

Section: Abc Transportersmentioning

confidence: 99%

Gastric cancer stem cells: therapeutic targets

et al. 2013

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During the past decade, a growing body of evidence has implied that cancer stem cells (CSCs) play an important role in the development of gastric cancer (GC). The notion that CSCs give rise to GC and may be responsible for invasion, metastasis, and resistance to treatment has profound implications for anti-cancer therapy. Recent major advances in the rapidly evolving field of CSCs have opened novel exciting opportunities for developing CSC-targeted therapies. Discovery of specific markers and signaling pathways in gastric CSCs (GCSCs), with the perfecting of technologies for identification, isolation, and validation of CSCs, may provide the basis for a revolutionary cancer treatment approach based on the eradication of GCSCs. Emerging therapeutic tools based on specific properties and functions of CSCs, including activation of self-renewal signaling pathways, differences in gene expression profiles, and increased activity of telomerase or chemoresistance mechanisms, are developing in parallel with advances in nanotechnology and bioengineering. The addition of GCSC-targeted therapies to current oncological protocols and their complementary application may be the key to successfully fighting GC.

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“…MSC-like cells can be isolated from tumors such as bone sarcomas, lipomas, and gastric cancers [21][22][23][24] . The characteristics of these MSC-like cells, with respect to morphology, gene expression, surface antigen expression, and differentiation potential, are similar to those of BM-derived MSCs (BM-MSCs).…”

Section: Introductionmentioning

confidence: 99%

Bone Marrow-Derived Mesenchymal Stem Cells Regulate Epithelial-Mesenchymal Transitions and Gastric Cancer Stem Cells

Aoyagi

Kizaki

Isobe

et al. 2017

Journal of Gastroenterology and Hepatology Research

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from MSCs. Direct contact between BM-derived MSCs (BMMSCs) and gastric cancer cells in vitro increases the proportion of CD133-positive gastric cancer cells. This mechanism is thought to involve stimulation of Wnt-5a and transforming growth factor (TGF)-β by BM-BMCs, directly affecting the gastric cancer cells. Moreover, direct contact between BM-MSCs and gastric cancer cells increases the expression of vimentin and Snail, which is a transcription factor that mediates epithelial-mesenchymal transitions (EMT). Human BM-MSCs can enhance the proliferation, invasion, and chemoresistance of gastric cancer cells. The regulatory mechanism involved is likely associated with increased expression of stem cell markers and EMT-related factors in gastric cancer cells. CD271, which is a marker of BM-MSCs, is expressed in scirrhous carcinoma, and the expression of Wnt-5a and TGF-β in cancer cells is up-regulated. BM-MSCs provide an advantageous tumor microenvironment for gastric cancer. Moreover, BM-MSC-related molecules may be considered biomarkers of gastric cancer. INTRODUCTIONDuring tumor progression, epithelial-mesenchymal transitions (EMT) contribute considerably to the malignant characteristics of tumors, including local invasion and distant metastasis [1,2] . EMT is the key phenomenon that tightly regulates the stem cell-like characteristics of both normal and malignant cells [3,4] . Since cancer stem cells (CSCs) in solid cancers were first identified in the early half of the 2000s, ABSTRACTTumorigenesis is driven by alterations in tumor cells and also changes in the stromal microenvironment. Mesenchymal stem cells (MSCs) are promising candidates for the treatment of various tumors. MSCs are unlikely to be rejected by the immune system, could potentially home to the tumor site, and may interact with tumor cells to influence their growth and metastasis. Using mouse models of inflammationinduced gastric cancer, at least 20% of cancer-associated fibroblasts were found to originate from bone marrow (BM) and were derived REVIEW

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Mesenchymal stem cell-like cells derived from human gastric cancer tissues

Cited by 81 publications

References 30 publications

In Vitro Evidence of the Presence of Mesenchymal Stromal Cells in Cervical Cancer and Their Role in Protecting Cancer Cells from Cytotoxic T Cell Activity

In Vitro Evidence of the Presence of Mesenchymal Stromal Cells in Cervical Cancer and Their Role in Protecting Cancer Cells from Cytotoxic T Cell Activity

Gastric cancer stem cells: therapeutic targets

Bone Marrow-Derived Mesenchymal Stem Cells Regulate Epithelial-Mesenchymal Transitions and Gastric Cancer Stem Cells

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