Mesenchymal Stem Cell-derived Extracellular Vesicle-enclosed microRNA-93 Prevents Hypoxic-ischemic Brain Damage in Rats

Shi, Xiaoding; Zhong, Xuelai; Deng, Lin; Wu, Xiaohong; Zhang, Pinyi; Zhang, Xin; Wang, Guonian

doi:10.1016/j.neuroscience.2022.06.037

Cited by 14 publications

(10 citation statements)

References 37 publications

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“…Hypoxic-ischemic encephalopathy and spinal cord injury are important causes of neuronal apoptosis, which can also be mitigated by MSCs. In the in vivo rat middle cerebral artery occlusion model and in vitro neuronal oxygen and glucose deprivation experiments, MSCs significantly inhibit abnormal apoptosis of neuronal and microglial, and improve neurobehavioral deficits [ 33 , 116 ]. And MSCs-derived exosomes or vesicles are the key mediators in this process [ 21 ].…”

Section: Mscs Improve Diseases By Inhibiting Apoptosismentioning

confidence: 99%

The dual role of mesenchymal stem cells in apoptosis regulation

Chen,

Xia,

Yao

et al. 2024

Cell Death Dis

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Mesenchymal stem cells (MSCs) are widely distributed pluripotent stem cells with powerful immunomodulatory capacity. MSCs transplantation therapy (MSCT) is widely used in the fields of tissue regeneration and repair, and treatment of inflammatory diseases. Apoptosis is an important way for tissues to maintain cell renewal, but it also plays an important role in various diseases. And many studies have shown that MSCs improves the diseases by regulating cell apoptosis. The regulation of MSCs on apoptosis is double-sided. On the one hand, MSCs significantly inhibit the apoptosis of diseased cells. On the other hand, MSCs also promote the apoptosis of tumor cells and excessive immune cells. Furthermore, MSCs regulate apoptosis through multiple molecules and pathways, including three classical apoptotic signaling pathways and other pathways. In this review, we summarize the current evidence on the regulation of apoptosis by MSCs.

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Section: Mscs Improve Diseases By Inhibiting Apoptosismentioning

confidence: 99%

The dual role of mesenchymal stem cells in apoptosis regulation

Chen,

Xia,

Yao

et al. 2024

Cell Death Dis

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“…In addition, BMSC-exos ameliorate cerebral infarction by transferring miR-23a-3p, thereby inducing microglia inactivation and M2 polarization (Dong et al 2022 ). By targeting the histone deacetylase 4 (HDAC4)/B-cell lymphoma 2 (Bcl-2) axis to prevent hippocampus neuronal death, miR-93 delivered by BMSC-derived EVs (BMSC-EVs) improves HIBD (Shi et al 2022 ). BMSC-exos carrying the long non-coding RNA ZFAS1 suppress oxidative stress and inflammation associated with ischemic stroke (Yang and Chen 2022 ).…”

Section: Evs In Brain–bone Marrow Crosstalkmentioning

confidence: 99%

Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles

et al. 2023

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A number of substances released by the brain under physiological and pathological conditions exert effects on other organs. In turn, substances produced primarily by organs such as bone marrow, adipose tissue, or the heart may have an impact on the metabolism and function and metabolism of the healthy and diseased brain. Despite a mounting amount of evidence supports such bidirectional communication between the brain and other organs, research on the function of molecular mediators carried by extracellular vesicles (EVs) is in the early stages. In addition to being able to target or reach practically any organ, EVs have the ability to cross the blood–brain barrier to transport a range of substances (lipids, peptides, proteins, and nucleic acids) to recipient cells, exerting biological effects. Here, we review the function of EVs in bidirectional communication between the brain and other organs. In a small number of cases, the role has been explicitly proven; yet, in most cases, it relies on indirect evidence from EVs in cell culture or animal models. There is a dearth of research currently available on the function of EVs-carrying mediators in the bidirectional communication between the brain and bone marrow, adipose tissue, liver, heart, lungs, and gut. Therefore, more studies are needed to determine how EVs facilitate communication between the brain and other organs.

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“…MiR-93 targets histone deacetylase 4 (HDAC4). HDAC4 deacetylates and thus inhibits the antiapoptotic molecule Bcl-2, leading to increased infarct volume and neuron apoptosis, and worsened neurobehavioral impairments [ 102 ].…”

Section: Enhancing the Stem Cell Epigenome For Treatment Of Ischemic ...mentioning

confidence: 99%

Minor Changes for a Major Impact: A Review of Epigenetic Modifications in Cell-Based Therapies for Stroke

Monsour

Gordon

Lockard

et al. 2022

IJMS

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Epigenetic changes in stroke may revolutionize cell-based therapies aimed at reducing ischemic stroke risk and damage. Epigenetic changes are a novel therapeutic target due to their specificity and potential for reversal. Possible targets for epigenetic modification include DNA methylation and demethylation, post-translational histone modification, and the actions of non-coding RNAs such as microRNAs. Many of these epigenetic modifications have been reported to modulate atherosclerosis development and progression, ultimately contributing to stroke pathogenesis. Furthermore, epigenetics may play a major role in inflammatory responses following stroke. Stem cells for stroke have demonstrated safety in clinical trials for stroke and show therapeutic benefit in pre-clinical studies. The efficacy of these cell-based interventions may be amplified with adjunctive epigenetic modifications. This review advances the role of epigenetics in atherosclerosis and inflammation in the context of stroke, followed by a discussion on current stem cell studies modulating epigenetics to ameliorate stroke damage.

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Mesenchymal Stem Cell-derived Extracellular Vesicle-enclosed microRNA-93 Prevents Hypoxic-ischemic Brain Damage in Rats

Cited by 14 publications

References 37 publications

The dual role of mesenchymal stem cells in apoptosis regulation

The dual role of mesenchymal stem cells in apoptosis regulation

Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles

Minor Changes for a Major Impact: A Review of Epigenetic Modifications in Cell-Based Therapies for Stroke

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