Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation

Cho, Kyung‐Ah; Cha, Je-Eun; Kim, Jung-Woo; Kim, Yu Hee; Ryu, Kyung‐Ha; Woo, So Youn

doi:10.1007/s13770-021-00395-4

Cited by 13 publications

(14 citation statements)

References 36 publications

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“…MSC exosomes have shown the potential in diseases treatment with the properties of MSC. 30–32 For example, MSC exosomes could regulate mast cell activation under inflammatory conditions 33 and suppress mast cell activation by PGE2 production and EP4 activation. 34 What’s more, during MSC culture, there are plenty of proteins and lipid mediators secreted in the MSC-conditioned medium and could be preserved without losing efficacy.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of mesenchymal stem cells for refractory inflammatory and immune skin diseases

Hua

Chen

Cheng

2022

Human Vaccines & Immunotherapeutics

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Inflammatory and immunological skin diseases such as psoriasis, systemic sclerosis, dermatomyositis and atopic dermatitis, whose abnormal skin manifestations not only affected life quality but also caused social discrimination, have been wildly concerned. Complex variables such as hereditary predisposition, racial differences, age and gender can influence the prevalence and therapeutic options. The population of patients with unsatisfactory curative effects under current therapies is growing, it’s advisable to seek novel and advanced therapies that are less likely to cause systemic damage. Mesenchymal stem cells (MSCs) have been proven with therapeutic benefits in tissue regeneration, self-renewal and differentiation abilities when treating refractory skin disorders in preclinical and clinical studies. Here we highlighted the immune modulation and inflammation suppression of MSCs in skin diseases, summarized current studies, research progress and related clinical trials, hoping to strengthen the confidence of promising MSCs therapy in future clinical application.

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Section: Introductionmentioning

confidence: 99%

Therapeutic potential of mesenchymal stem cells for refractory inflammatory and immune skin diseases

Hua

Chen

Cheng

2022

Human Vaccines & Immunotherapeutics

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“…Cho et al. conducted a study that showed tonsil-derived mesenchymal stem cells (T-MSCs) and T-MSC-derived exosomes can attenuate TLR7-mediated mast cell activation in mice which leads to the reduction of skin inflammation ( Cho et al., 2022 ). The immune system in the skin, which include mast cells, reacts to a variety of environmental and pathological stimuli, such as pathogens ( Jiménez et al., 2021 ).…”

Section: Exosomes-tlrs Intraction and Infection Controlmentioning

confidence: 99%

Regulation of immune responses to infection through interaction between stem cell-derived exosomes and toll-like receptors mediated by microRNA cargoes

Moghaddam,

Behzadi,

Sedighian

et al. 2024

Front. Cell. Infect. Microbiol.

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Infectious diseases are among the factors that account for a significant proportion of disease-related deaths worldwide. The primary treatment approach to combat microbial infections is the use of antibiotics. However, the widespread use of these drugs over the past two decades has led to the emergence of resistant microbial species, making the control of microbial infections a serious challenge. One of the most important solutions in the field of combating infectious diseases is the regulation of the host’s defense system. Toll-like receptors (TLRs) play a crucial role in the first primary defense against pathogens by identifying harmful endogenous molecules released from dying cells and damaged tissues as well as invading microbial agents. Therefore, they play an important role in communicating and regulating innate and adaptive immunity. Of course, excessive activation of TLRs can lead to disruption of immune homeostasis and increase the risk of inflammatory reactions. Targeting TLR signaling pathways has emerged as a new therapeutic approach for infectious diseases based on host-directed therapy (HDT). In recent years, stem cell-derived exosomes have received significant attention as factors regulating the immune system. The regulation effects of exosomes on the immune system are based on the HDT strategy, which is due to their cargoes. In general, the mechanism of action of stem cell-derived exosomes in HDT is by regulating and modulating immunity, promoting tissue regeneration, and reducing host toxicity. One of their most important cargoes is microRNAs, which have been shown to play a significant role in regulating immunity through TLRs. This review investigates the therapeutic properties of stem cell-derived exosomes in combating infections through the interaction between exosomal microRNAs and Toll-like receptors.

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“…EVs derived from hPT-MSCs (hPT-MSC-EVs) could attenuate TLR7-mediated activation of mast cells. In this study, imiquimod (IMQ, the agonist for TLR7) was employed to activate human mast cell line (HMC-1) ( 13 ). The introduction of hPT-MSC-EVs inhibited IMQ-induced HMC-1 activation and the expression of inflammatory cytokines in HMC-1 cells via transferring miRNAs like has-miR-214-3p and has-miR-424-5p.…”

Section: Regulation Of Immune Cell Function By Msc-evsmentioning

confidence: 99%

“…Mesenchymal stem cells (MSCs) are a kind of multipotent stem cells which exist in a wide range of tissues such as bone marrow (BM) ( 9 ), adipose tissue (AD) ( 10 ), umbilical cord (UC) ( 11 ), decidua ( 12 ), palatine tonsil (PT) ( 13 ), aborted fetal liver (FL) ( 14 ), etc. MSCs are believed to exert immunomodulatory or regenerative effects on the injured tissues in various diseases through secreting paracrine factors including extracellular vesicles (EVs) ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells

Liu

Wei

Lu³

et al. 2023

Front. Immunol.

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Various intractable inflammatory diseases caused by disorders of immune systems have pressed heavily on public health. Innate and adaptive immune cells as well as secreted cytokines and chemokines are commanders to mediate our immune systems. Therefore, restoring normal immunomodulatory responses of immune cells is crucial for the treatment of inflammatory diseases. Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) are nano-sized double-membraned vesicles acting as paracrine effectors of MSCs. MSC-EVs, containing a variety of therapeutic agents, have shown great potential in immune modulation. Herein, we discuss the novel regulatory functions of MSC-EVs from different sources in the activities of innate and adaptive immune cells like macrophages, granulocytes, mast cells, natural killer (NK) cells, dendritic cells (DCs) and lymphocytes. Then, we summarize the latest clinical trials of MSC-EVs in inflammatory diseases. Furthermore, we prospect the research trend of MSC-EVs in the field of immune modulation. Despite the fact that the research on the role of MSC-EVs in regulating immune cells is in infancy, this cell-free therapy based on MSC-EVs still offers a promising solution for the treatment of inflammatory diseases.

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Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation

Cited by 13 publications

References 36 publications

Therapeutic potential of mesenchymal stem cells for refractory inflammatory and immune skin diseases

Therapeutic potential of mesenchymal stem cells for refractory inflammatory and immune skin diseases

Regulation of immune responses to infection through interaction between stem cell-derived exosomes and toll-like receptors mediated by microRNA cargoes

Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells

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