Mesenchymal Stem Cell-Derived Exosomal miR-150-3p Affects Intracerebral Hemorrhage By Regulating TRAF6/NF-κB Axis, Gut Microbiota and Metabolism

Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease

“…Furthermore, miR-181a in MSC-Exs can alleviate a DSS-induced colitis model and restore its gut microbiota to a healthy state [76]. In another study, miR-150-3p in MSC-Exs was found to regulate the TRAF6/NF-κB axis and gut microbiota, thereby improving a mouse ICH (intracerebral hemorrhage) model [94]. At present, there is a paucity of research investigating the related molecules and signaling pathways between MSC-Exs and gut microbiota.…”

Application of biomaterials in the treatment of intracerebral hemorrhage

“…56 Meanwhile, Sun et al found that MSC-derived exosomes containing miR-150-3p could affect ICH injury by modulating the TRAF6/NF-κB axis, gut microbiota, and metabolism to improve neurological function, decrease brain water content, and reduce the expression of inflammatory factors. 57 In contrast, Zhang et al prepared miR-21-overexpressing MSCs and directly injected the MSCs into the brains of ICH rats for treatment, and it was found that the therapeutic effects were actually mediated through exosomes derived from miR-21-overexpressing MSCs. 58 Furthermore, Duan et al observed that exosomes from bone marrow-derived mesenchymal stem cells (BMSCs), enriched with miR-146a-5p, were capable of mitigating neuronal apoptosis.…”

Extracellular Vesicles: A Crucial Player in the Intestinal Microenvironment and Beyond

“…EVs secreted by murine bone marrow MSCs induce alterations in the gut microbiota composition, specifically Proteobacteria , Muribaculaceae , Lachnospiraceae , and Acinetobacter . These alterations in the gut microbiota play a beneficial regulatory role in cerebral hemorrhage [ 112 ]. On the other hand, the disturbance of gut microbiota in mice with Alzheimer’s disease inhibits the neuroprotective effect of MSC-EVs, while the administration of antibiotics amplifies the therapeutic benefits of MSC-EVs by altering gut microbiota composition, affecting tryptophan metabolism, enhancing intestinal barrier function, reducing intestinal permeability, and impeding bacterial infiltration from the intestinal lumen and diffusion throughout the body, hence collectively attenuating neuroinflammation in Alzheimer’s disease [ 113 ].…”