2015
DOI: 10.1159/000438545
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Mesenchymal Stem Cell Conditioned Medium Promotes Proliferation and Migration of Alveolar Epithelial Cells under Septic Conditions In Vitro via the JNK-P38 Signaling Pathway

Abstract: Background/Aims: Mesenchymal stem cell (MSC) based therapies may be useful for treating acute respiratory distress syndrome (ARDS), but the underlying mechanisms are incompletely understood. We investigated the impact of human umbilical cord Wharton's jelly-derived MSC (hUC-MSC) secreted factors on alveolar epithelial cells under septic conditions and determined the relevant intracellular signaling pathways. Methods: Human alveolar epithelial cells (AEC) and primary human small airway epithelial cells (SAEC) w… Show more

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Cited by 51 publications
(47 citation statements)
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“…The dose for the secretomes was based on previous reports [38]. Four hours later, glucose level in culture media was raised from basal level (25mM glucose) to hyperglycemic level (45mM glucose).…”
Section: Resultsmentioning
confidence: 99%
“…The dose for the secretomes was based on previous reports [38]. Four hours later, glucose level in culture media was raised from basal level (25mM glucose) to hyperglycemic level (45mM glucose).…”
Section: Resultsmentioning
confidence: 99%
“…p38 phosphorylation in MTX-treated and MTX plus vitamin C-treated cells. The MAPK family kinases ERK, JNK and p38 are involved in cell death, cell differentiation, and cell proliferation (46)(47)(48). In the present study, expression levels of EKR, JNK, p38 and their phosphorylated (activated) forms (p-ERK, p-JNK and p-p38) were estimated by western blotting.…”
Section: Mtx-treatment and Combined Mtx Plus Vitamin C Treatment Indumentioning
confidence: 85%
“…9 Previous studies have shown that MSC-CM promotes proliferation and migration of alveolar epithelial cells under septic conditions. 10 However, few studies have been specially designed to study the effects of MSC secretion factors in kidney diseases.…”
Section: Introductionmentioning
confidence: 99%
“…More importantly, if the factors secreted by the MSC can slow the progression of CKD, this can overcome the drawbacks of allogeneic MSC transplantation, such as inconvenience, immunological rejection, and MSC tumorigenesis . Previous studies have shown that MSC‐CM promotes proliferation and migration of alveolar epithelial cells under septic conditions . However, few studies have been specially designed to study the effects of MSC secretion factors in kidney diseases.…”
mentioning
confidence: 99%