Mesenchymal stem cell application improves tendon healing via anti-apoptotic effect (Animal study)

Selek, Özgür; Buluç, Levent; Müezzínoğlu, Bahar; Ergün, Riza Emre; Ayhan, Selda; Karaöz, Erdal

doi:10.3944/aott.2014.2985

Cited by 22 publications

(20 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the 12th week, apoptosis was minimally present in the study group and was clearly increased in the control group. Increase in tendon strength was signifi cantly higher in the study group than in the control [ 45 ].…”

Section: Different Treatment Modalities In Tendon Healingmentioning

confidence: 85%

Updated Animal Models in Orthopaedic Research

Öztuna

2015

European Instructional Lectures

View full text Add to dashboard Cite

Cionne et al. designed a study to characterize the early infl ammatory phase of fl exor tendon healing with the goal of identifying infl ammationrelated targets for future treatments. Canine fl exor tendons were transected and repaired with core and running epitenon suture. A controlled passive motion rehabilitation protocol was started on the fi rst post-operative day. The infl ammatory response was monitored for 9 days. Temporal changes in immune cell populations and gene expression of infl ammation-, matrix degradation-, and extracellular matrixrelated factors were examined. The most dramatic effect was a greater than 4,000-fold up-regulation in the expression of the proinfl ammatory factor IL-1β. While an infl ammatory response is likely necessary for healing to occur, high levels of pro-infl ammatory cytokines may result in impaired tendon healing. The tendon treatment approaches should include the modulation strategies of the infl ammatory phase of healing [ 37 ]. AbstractThere has been growing innovation in Orthopaedic basic science research over the past years. This study presents the newest knowledge about the musculoskeletal tissue healing which were investigated by animal studies and recently published in the major Orthopaedic journals. These studies demonstrate some modifi cations in methodology of animal models and a multidisciplinary approach to understanding the mechanisms underlying tissue healing and regeneration. Besides, the effects of gene therapies, different molecules, growth factors, some drugs which are widely used in daily practice and popular modalities (like ESWT and PRP) on tissue regeneration are summarized in this manuscript.

show abstract

Section: Different Treatment Modalities In Tendon Healingmentioning

confidence: 85%

Updated Animal Models in Orthopaedic Research

Öztuna

2015

European Instructional Lectures

View full text Add to dashboard Cite

show abstract

“…In many studies on animals, MSC administration has been shown to accelerate Achilles tendon recovery and have positive effects (14,15). Studies have shown that it increases tendon strength significantly and that good histopathologic scores have been obtained, but its mechanism of action has not been fully explained yet (16). The effects of MSCs not only involve transdifferentiating into other cells, but also causes the release of paracrine cells, such as growth factors and cytokines (17).…”

Section: Introductionmentioning

confidence: 97%

Comparison of the early period effects of bone marrow-derived mesenchymal stem cells and platelet-rich plasma on the Achilles tendon ruptures in rats

Yüksel¹,

Güleç

Gültekin

et al. 2016

Connective Tissue Research

View full text Add to dashboard Cite

rBM-MSC and PRP promote the recovery of the tendon and increase its structural strength. The use of PRP and MSC provides hope for the treatment of the Achilles tendon ruptures that limit human beings' functionalities and quality of life, particularly for athletes. It is thought that the use of MSC can be more effective for tendon healing; hence, more extensive and advanced studies are needed on this topic.

show abstract

“…After 12 weeks the strength of tendons was significantly improved. Immunohistochemical evaluation showed increased localization of MSCs in the area of the repair zone [53]. Bone marrow derived MSCs have been shown to improve the mechanical properties of rabbits' patellar tendons [6].…”

Section: Healing Of the Tendonmentioning

confidence: 99%

“…Animal models showed positive results of MSCs application in tendon repair process. Authors obtained MSCs from femurs and tibias of rats and injected to the ruptured Achilles tendon [53]. After 12 weeks the strength of tendons was significantly improved.…”

Section: Healing Of the Tendonmentioning

confidence: 99%

Tendon — function-related structure, simple healing process and mysterious ageing

Zabrzyński¹,

Łapaj

Paczesny³

et al. 2018

Folia Morphol

View full text Add to dashboard Cite

Tendons are connective tissue structures of paramount importance to human ability of locomotion. The understanding of their physiology and pathology is gaining importance as advances in regenerative medicine are being made today. So far, very few studies were conducted to extend the knowledge about pathology, healing response and management of tendon lesions.In this paper we summarize actual knowledge on structure, process of healing and ageing of the tendons. The structure of tendon is optimized for the best performance of the tissue. Despite the simplicity of the healing response, numerous studies showed, that the problems with full recovery are common and much more significant than we thought, that is why we discussed the issue of immobilization and mechanical stimulation during healing process. The phenomenon of tendons' ageing is poorly understood, although it seems to be a natural and painless process, it is completely different to degeneration in tendinopathy. Recent studies of biological treatment reported faster and optimal healing of the tendons when augmented by growth factors and stem cells. Despite advances in biology of tendons, management of their injuries is still a challenge for physicians, therefore further studies are required to improve treatment outcomes.

show abstract

Mesenchymal stem cell application improves tendon healing via anti-apoptotic effect (Animal study)

Abstract: The application of MSCs to decrease re-ruptures has a positive effect on tendon strength, probably due to their anti-apoptotic effects. Mesenchymal stem cell application can be used percutaneously and is effective in clinical practice in the late stages of tendon healing.

Cited by 22 publications

References 20 publications

Updated Animal Models in Orthopaedic Research

Updated Animal Models in Orthopaedic Research

Comparison of the early period effects of bone marrow-derived mesenchymal stem cells and platelet-rich plasma on the Achilles tendon ruptures in rats

Tendon — function-related structure, simple healing process and mysterious ageing

Contact Info

Product

Resources

About