Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development

Asahina, Kinji; Tsai, Shirley Y.; Li, Peng; Ishii, Masahiko; Maxson, Robert E.; Sucov, Henry M.; Tsukamoto, Hidekazu

doi:10.1002/hep.22721

Cited by 214 publications

(249 citation statements)

References 28 publications

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“…4,5 This indicates a mesodermal origin of stellate cells, which was confirmed by a very recent study. 6 In this study, submesothelial cells positive for activated leukocyte cell adhesion molecule (ALCAM) were shown to store lipid droplets after retinol treatment and to acquire the phenotype of HSCs. 6 ALCAM is a cell-surface immunoglobulin superfamily member expressed by primitive hematopoietic stem cells and associated with embryonic hematopoiesis as well as vasculogenesis.…”

Section: S Tellate Cells Reside Within the Perisinusoidal Space Ofmentioning

confidence: 88%

“…6 In this study, submesothelial cells positive for activated leukocyte cell adhesion molecule (ALCAM) were shown to store lipid droplets after retinol treatment and to acquire the phenotype of HSCs. 6 ALCAM is a cell-surface immunoglobulin superfamily member expressed by primitive hematopoietic stem cells and associated with embryonic hematopoiesis as well as vasculogenesis. 7 Interestingly, stellate cells of rat liver display characteristics of stem/ progenitor cells.…”

Section: S Tellate Cells Reside Within the Perisinusoidal Space Ofmentioning

confidence: 88%

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The niche of stellate cells within rat liver

et al. 2009

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Section: S Tellate Cells Reside Within the Perisinusoidal Space Ofmentioning

confidence: 88%

Section: S Tellate Cells Reside Within the Perisinusoidal Space Ofmentioning

confidence: 88%

The niche of stellate cells within rat liver

et al. 2009

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“…Some researchers consider that these cells are derived from mesenchymal cells of septum transversum, which form the submesothelial layer under the liver capsule [26,28,29], but their epithelial origin cannot be excluded [30]. The number of hepatic stellate cells increases in the course of development [25].…”

Section: Hepatic Stellate Cellsmentioning

confidence: 99%

“…In either adult or fetal liver, fibroblasts (myofibroblasts) are located in the region of portal triads [20,25], around central veins, and in the Glisson capsule [22] or, in the fetal liver, in the submesothelial layer of mesenchymal cells [29]. Portal myofibroblasts express smooth muscle actin and desmin and are morphologically similar to activated stellate cells [20,32].…”

Section: Fibroblasts and Myofibroblastsmentioning

confidence: 99%

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Hematopoietic Microenvironment in the Fetal Liver: Roles of Different Cell Populations

Payushina

2012

ISRN Cell Biology

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Hematopoiesis is the main function of the liver during a considerable period of mammalian prenatal development. Hematopoietic cells of the fetal liver exist in a specific microenvironment that controls their proliferation and differentiation. This microenvironment is created by different cell populations, including epitheliocytes, macrophages, various stromal elements (hepatic stellate cells, fibroblasts, myofibroblasts, vascular smooth muscle and endothelial cells, mesenchymal stromal cells), and also cells undergoing epithelial-to-mesenchymal transition. This paper considers the involvement of these cell types in the regulation of fetal liver hematopoiesis.

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Generation of mesothelial progenitor‐like cells from mouse‐induced pluripotent stem cells

Inagaki

Kokudo

et al. 2019

FEBS Letters

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Mesothelial cells, which cover the surface of visceral organs and serous cavities in mammals, play a crucial role in preventing adhesion. We previously reported that primary mesothelial progenitor cells (MPCs) can not only prevent postoperative adhesion but also promote liver regeneration after hepatectomy. Induced pluripotent stem cells (iPSCs) have the potential to be used for regenerative medicine. Here, we have established a differentiation protocol for mouse iPSC‐derived MPCs (miMPCs) via the exposure to defined factors, as well as purification using MPC‐specific cell surface antigens. Furthermore, the miMPCs had the ability to suppress postoperative adhesion and facilitate liver regeneration. This is the first report highlighting the generation of functional miMPCs, which may offer potential for de novo cell therapy.

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Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development

Cited by 214 publications

References 28 publications

The niche of stellate cells within rat liver

The niche of stellate cells within rat liver

Hematopoietic Microenvironment in the Fetal Liver: Roles of Different Cell Populations

Generation of mesothelial progenitor‐like cells from mouse‐induced pluripotent stem cells

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