Mesenchymal Hamartoma of the Liver: A Benign Tumor with Deceptive Prognosis in the Perinatal Period

Cornette, J.; Festen, Sebastiaan; Hoonaard, Thelma L. van den; Steegers, E.A.P.

doi:10.1159/000212057

Cited by 31 publications

(14 citation statements)

References 62 publications

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“…The ultrasonographic appearance of the lesion was confusing because it did not resemble anything we had seen in the past 20 years. However, the findings were similar to multicystic lesions described for liver hamartoma in human medicine [2,4-6]. In our case, it was not clear initially whether the dilated vessels were blood vessels or bile ducts.…”

Section: Case Presentationsupporting

confidence: 84%

Ultrasonographic findings in a cow with vascular hamartoma of the liver: case report

et al. 2011

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BackgroundThis is the first description of the ultrasonographic findings in a cow with vascular hamartoma of the liver.Case presentationUltrasonographic examination of a six-year-old Swiss Braunvieh cow revealed an excessive number of hypoechogenic blood vessels in the liver parenchyma and a thrombus in the right hepatic vein. The activities of the liver enzymes and the concentration of bilirubin were within the reference ranges. At postmortem examination, a poorly delineated, non-encapsulated lesion, measuring approximately 10 cm × 10 cm in diameter, was found in the right liver lobe. The cut surface of the lesion was sponge-like and contained extremely dilated blood vessels, one of which was occluded with a branching red thrombus. A vascular hamartoma of the liver with thrombosis was diagnosed based on the histological findings.ConclusionsTo our knowledge, this is the first description of the ultrasonographic findings of vascular hamartoma of the liver in a cow. Hamartoma should be considered part of the differential diagnosis in cows with an abnormally large number of blood vessels in the liver parenchyma. This case report broadens the spectrum of liver diseases and ultrasonographic findings of the liver in cattle.

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Section: Case Presentationsupporting

confidence: 84%

Ultrasonographic findings in a cow with vascular hamartoma of the liver: case report

et al. 2011

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“…Table 2 shows a comparison of outcomes of reported cases. Of the eight cases found in the literature, there were two fetal demises, one neonatal death, four postnatal surgically resections (two immediately postnatal, one at 3 months and one at 11 months of age), and one had serial postnatal percutaneous decompression with full resolution [3][4][5][6][7][8][9][10]. HMH should always be considered a likely diagnosis in cases of PMD with an associated abdominal mass seen antenatally on ultrasonography.…”

Section: Discussionmentioning

confidence: 94%

Placental Mesenchymal Dysplasia with Hepatic Mesenchymal Hamartoma: A Case Report and Literature Review

Harris

Carreon

Vohra

et al. 2013

Fetal and Pediatric Pathology

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Placental mesenchymal dysplasia (PMD) is characterized by placentomegaly and grapelike vesicles resembling a partial molar pregnancy and in most cases, a phenotypically normal fetus. Hepatic mesenchymal hamartoma (HMH) is a benign hamartomatous proliferation of mesenchymal liver tissue. PMD has been associated with HMH. Although rare, in combination, it is known to carry a poorer prognosis than in fetuses without structural abnormalities. There are only a few reported cases of PMD and associated HMH with varying management strategies and outcomes, precluding ascertainment of the most appropriate treatment plan. We present a case of PMD with associated cystic HMH resulting in fetal death. We also reviewed the published literature on this issue and explored possible management strategies to prevent adverse fetal and neonatal outcomes.

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“…Thus, when a liver tumor presents as a PMD complication, the parents should be counseled that the fetal prognosis may be poor. Some case reports have described PMD being diagnosed in conjunction with MHL, whereas others describe PMD being detected after an MHL diagnosis . Therefore, obstetricians may need to perform detailed placental ultrasound studies to identify this PMD complication when a fetal liver tumor is found.…”

Section: Discussionmentioning

confidence: 99%

Rare fetal complications associated with placental mesenchymal dysplasia: A report of two cases

Jimbo

Fujita

Yumoto

et al. 2014

J of Obstet and Gynaecol

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Placental mesenchymal dysplasia (PMD) is a rare disease that may be difficult to distinguish from molar pregnancy. The disease is associated with major fetal complications, including Beckwith-Wiedemann syndrome, fetal growth restriction and intrauterine fetal death. Rarely, fetal hematological disorders and liver tumors also may occur. Two patients were referred to our hospital during their second trimesters because of suspected molar pregnancies. Fetal karyotyping and maternal serum human chorionic gonadotropin level determinations led to the PMD diagnoses. In one case, the maternal clinical course was normal, but the neonate suffered from disseminated intravascular coagulation and needed a platelet transfusion. In the second case, the PMD decreased during pregnancy, but a gradually increasing fetal liver tumor appeared. The tumor was diagnosed as mesenchymal hamartoma, based on ultrasound and magnetic resonance imaging studies. The neonate was delivered without cardiovascular compromise. Due to the difficulty of immediate surgical treatment, expectant management, with close follow-up, was chosen.

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Mesenchymal Hamartoma of the Liver: A Benign Tumor with Deceptive Prognosis in the Perinatal Period

Cited by 31 publications

References 62 publications

Ultrasonographic findings in a cow with vascular hamartoma of the liver: case report

Ultrasonographic findings in a cow with vascular hamartoma of the liver: case report

Placental Mesenchymal Dysplasia with Hepatic Mesenchymal Hamartoma: A Case Report and Literature Review

Rare fetal complications associated with placental mesenchymal dysplasia: A report of two cases

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