Mesenchymal hamartoma of the chest wall in a 10-year-old girl mimicking malignancy: a case report

Tanaka, Tomoko; Fumino, Shigehisa; Shirai, Toshiharu; Konishi, Eiichi; Tajiri, Tatsuro

doi:10.1007/s00256-018-3106-2

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…Mesenchymal hamartoma of the chest wall, also known as benign mesenchymoma, infantile osteochondroma, osteochondrosarcoma, and infantile cartilaginous hamartoma, is a benign lesion that usually presents as a deforming chest wall mass in an infant or young child [19]. This lesion accounts for 0.03 % of primary bone tumors [20]. It typically arises along the ribs and is characterized by a benign proliferation of precursors of bone tissue with a prominent cartilaginous component, oval to spindled mesenchymal cells with no atypia or abnormal mitotic activity, smooth muscle, and hemorrhagic cavities with osteoclast-like giant cells, imparting aneurysmal bone cyst-like appearance [19,21].…”

Section: Mesenchymal Hamartoma Of the Chest Wallmentioning

confidence: 99%

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Pediatric thoracic mass lesions: Beyond the common

Orman

Masand

Hicks

et al. 2020

European Journal of Radiology Open

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Thoracic mass lesions can be categorized as originating in one of the three major compartments: a) chest wall and pleura, b) lung parenchyma and airways, c) mediastinum. While some of these, such as lymphoma, are common in both children and adults, others are rare and unique to childhood. The goal of this review is to familiarize radiologists with unusual but distinctive mass lesions of the pediatric thorax.

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Section: Mesenchymal Hamartoma Of the Chest Wallmentioning

confidence: 99%

“…1) and magnetic resonance imaging (MRI) may show mineralized matrix and hemorrhagic cystic components [22]. Differential diagnosis include osteosarcoma or chondrosarcoma [20]. The size of the mass may decrease even without treatment and prognosis is excellent.…”

Section: Mesenchymal Hamartoma Of the Chest Wallmentioning

confidence: 99%

Pediatric thoracic mass lesions: Beyond the common

Orman

Masand

Hicks

et al. 2020

European Journal of Radiology Open

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“…In patient 1, the imaging finding of a paravertebral mass in an adult appeared to mimic a posterior mediastinal tumor and the radiologist suggested the possibility of a neurogenic tumor. Malignant lesions such as congenital neuroblastoma, Ewing's sarcoma, malignant teratoma, osteosarcoma, or chondrosarcoma cannot be excluded in the presence of cortical erosion, rib destruction, or deformation of adjacent ribs as seen on imaging [16,17]. Biopsy of the lesion can be complicated by severe bleeding because of disruption of the vascular spaces; therefore, needle biopsy should be performed cautiously [1,2].…”

Section: Discussionmentioning

confidence: 99%

Chondromesenchymal hamartomas in a 24-year-old male mimicking a posterior mediastinal tumor and a 5-month-old boy with postoperative disseminated intravascular coagulation: two case reports

Zheng

Zuo

et al. 2020

Diagn Pathol

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Background Chondromesenchymal hamartoma of the chest wall is a rare, benign disease that usually presents at birth or in early infancy. It typically involves one or more ribs, forming a unilateral or bilateral extrapleural mass. Patients may be asymptomatic or complain of mild respiratory distress depending on tumor size and location. To the best of our knowledge, only two of the approximately 100 cases reported so far are adults. Case presentation We present two cases of chondromesenchymal hamartoma. The first case involved the left fifth rib in a 24-year-old male, in close proximity to the fifth vertebral body in the left posterior mediastinum, mimicking a posterior mediastinal tumor on imaging. The tumor was excised via thoracoscopy and the patient had an uneventful postoperative course. The second case was that of a 5-month-old boy, who had a tumor involving the left fifth and sixth ribs which caused thoracic cage collapse. Following en bloc resection of the tumor and the involved rib segments, the patient was transferred to the intensive care unit for treatment of pulmonary infection and disseminated intravascular coagulation (DIC). He was discharged from the hospital in stable condition 11 days later. On histopathology, the tumor was found to be a chondromesenchymal hamartoma with immature spindle-shaped mesenchymal cells, plate-like hyaline cartilage, areas of woven bone formation, endochondral ossification and calcification, osteoclastic giant cells, and secondary aneurysmal bone cysts. Conclusions Although the presently reported cases have morphological characteristics similar to previously reported ones, they had distinct radiological and clinical characteristics. Patient 1 is only the third report of an adult with chondromesenchymal hamartoma. His case was characterized by its radiological appearance mimicking a posterior mediastinal tumor. Patient 2 represents the first documentation of DIC as a postoperative complication following excision of a chondromesenchymal hamartoma. We present these two cases to provide clinicopathological insights regarding this extremely rare tumor that are relevant to both pathologists and clinicians.

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“…Surgery or conservative treatment are suggested in these tumors ( 35 ). Surgery encompasses radical resection of the rib or the involved bone portion with safe margins and it is proposed to symptomatic patients.…”

Section: Tumor Originating From Bone Tissuementioning

confidence: 99%

Benign tumors of the chest wall

Minervini,

Sergi,

Scarci

et al. 2024

J Thorac Dis

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Benign tumors of the chest wall are rare tumors that might arise from all the tissues of the chest: vessels, nerves, bones, cartilage, and soft tissues. Despite benign features, these tumors can have several histological characteristics and different behaviors. Even if they do not influence life expectancy, rarely they may have a potential risk of malignant transformation. They can cause several, oft, unspecific symptoms but more than 20% of affected patients are asymptomatic and are being diagnosed incidentally on chest radiograph or computed tomography scan. Pain is the most common described symptom. Together with a detailed medical history, a rigorous and meticulous clinical and radiological assessment is mandatory. If radiological features are unclear or in case surgery could not be performed, a biopsy should be indicated to establish a diagnosis. Radical surgical resection can often be offered to resect and cure these neoplasms, but this is might not be true for all types of tumors and, in some cases, their dimension or position might contra-indicate surgery. Given the rarity of these tumors, there is a lack of treatment’s guidelines and prospective trials that include a significant number of patients. This review discusses, according to the latest evidence, the histological features and the best treatment of several chest wall benign tumors.

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Mesenchymal hamartoma of the chest wall in a 10-year-old girl mimicking malignancy: a case report

Cited by 7 publications

References 14 publications

Pediatric thoracic mass lesions: Beyond the common

Pediatric thoracic mass lesions: Beyond the common

Chondromesenchymal hamartomas in a 24-year-old male mimicking a posterior mediastinal tumor and a 5-month-old boy with postoperative disseminated intravascular coagulation: two case reports

Benign tumors of the chest wall

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