Mesenchymal gaucho homing on the range

Abstract

GD1 is a disorder whose pathophysiology is manifested primarily in tissue macrophages.1 In this issue of Blood, Campeau and colleagues demonstrate that lysosomal glucocerebrosidase deficiency in GD1 bone marrow MSCs is associated with increased cellular glucosylceramide and up-regulation of inflammatory mediators that may promote bone mineral loss and hematologic malignancy.2