Mesenchymal dysplasia of the placenta

Gibson, Brent R.; Muir-Padilla, J.; Champeaux, Anne L.; Suarez, Eric S.

doi:10.1016/j.placenta.2003.12.008

Cited by 44 publications

(34 citation statements)

References 6 publications

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“…Nowadays its incidence is 0.02%, with a reported female:male ratio as 3.6:1 [3]. PMD may be underdiagnosed as it can be unfamiliar to many pathologists.…”

Section: Discussionmentioning

confidence: 99%

Placental mesenchymal dysplasia: can early diagnosis ensure a good materno-foetal outcome? A case report

Gizzo

Gangi

Patrelli

et al. 2012

Arch Gynecol Obstet

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Placental mesenchymal dysplasia is a rare disorder characterized by an increased size placenta with cystic villi and ectasic vessels. The correct diagnosis is very important, because placental mesenchymal dysplasia is usually compatible with a normal foetal morphology and a good materno-foetal outcome. An accurate ultrasound evaluation can help in the identification of characteristic patterns associated to this trophoblastic disease, particularly to distinguish it from its main differential diagnosis, i.e. hydatidiform mole. We report an early second-trimester ultrasound diagnosis of placental mesenchymal dysplasia complicated by foetal growth restriction, but with normal female karyotype and good healthy baby.

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“…Nowadays its incidence is 0.02%, with a reported female:male ratio as 3.6:1 [3]. PMD may be underdiagnosed as it can be unfamiliar to many pathologists.…”

Section: Discussionmentioning

confidence: 99%

Placental mesenchymal dysplasia: can early diagnosis ensure a good materno-foetal outcome? A case report

Gizzo

Gangi

Patrelli

et al. 2012

Arch Gynecol Obstet

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“…All articles without an abstract or with unavailable full text were excluded. We identified 49 articles including 110 cases of PMD [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49]. …”

Section: Literaturementioning

confidence: 99%

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Ohira¹,

Ookubo²,

Tanaka³

et al. 2013

Gynecol Obstet Invest

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Placental mesenchymal dysplasia (PMD) is characterized by multiple hypoechoic vesicles which are similar to molar changes in the placenta; however, the process of such morphological changes of PMD during pregnancy has not been fully understood. We performed a review of all PMD cases published in English and identified 49 articles including 110 cases. With regard to the gestational age at which the multicystic pattern was seen,approximately 70% of cases were diagnosed at 13-20 weeks of gestation. Another characteristic feature of PMD is varicose dilation of fetal chorionic vessels. As many as 90% of cases were diagnosed as placenta with dilated fetal chorionic vessels in the third trimester. We also report a case of PMD which was found at 10 weeks of gestation according to ultrasonic molar patterns. Serial observations of the placenta using ultrasound and magnetic resonance imaging revealed that multicystic lesions became smaller after 23 weeks. In contrast, dilated placental vessels on the fetal side became apparent at 38 weeks. The present review highlights that placental vesicular lesions of PMD may precede dilation of fetal chorionic vessels during pregnancy. It also indicates the potential of a gradual reduction in size of PMD's placental vesicular lesions by serial study of placental images.

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“…4 Placental mesenchymal dysplasia (PMD) is a distinct placental phenotype that has often been misdiagnosed as a PHM and therefore has also been referred to as a ''pseudo partial mole''. [5][6][7][8][9] Placentas with PMD are typically larger than average and show cystic areas on ultrasound but can co-exist with a completely normal fetus; however, intrauterine growth restriction and fetal or neonatal death are common.…”

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confidence: 99%

Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia

Kaiser‐Rogers

2005

Journal of Medical Genetics

168

171

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Preferential allocation of the normal cells into the trophoblast explains the absence of trophoblast overgrowth, a key feature of this syndrome. Interestingly, the distribution of androgenetic cells appears to differ from that reported for artificially created androgenetic mouse chimeras. Androgenetic mosaicism for the first time provides an aetiology for PMD, and may be a novel mechanism for BWS and unexplained intrauterine growth restriction.

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Mesenchymal dysplasia of the placenta

Cited by 44 publications

References 6 publications

Placental mesenchymal dysplasia: can early diagnosis ensure a good materno-foetal outcome? A case report

Placental mesenchymal dysplasia: can early diagnosis ensure a good materno-foetal outcome? A case report

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia

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