Mesenchymal chondrosarcoma metastasising to the pancreas

Paasch, Christoph; Santo, Gianluca De; Boettge, Katherina Renate; Strik, M. W.

doi:10.1136/bcr-2018-226369

Cited by 7 publications

(8 citation statements)

References 22 publications

(10 reference statements)

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“…Due to the limited cases and lack of large-sized randomized clinical trials, mesenchymal chondrosarcoma has no standard treatment. However, based on several case experiences, the consensus is that patients should receive radical surgery and possible chemotherapy [ 4 ]. The best chemotherapy regimen is not well established.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case Report of Mesenchymal Chondrosarcoma with Pancreatic Metastasis

Chen

Chou

2022

Medicina

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Background: Mesenchymal chondrosarcoma is a rare but aggressive subtype of sarcoma. The majority of involvement locates in the axial skeleton. Treatment modalities include radical surgery, local radiotherapy, and systemic chemotherapy. However, the long-term survival outcome remains poor. Case presentation: We present the case of a 33-year-old male with a palpable chest wall mass for one year, diagnosed with mesenchymal chondrosarcoma with surgical removal. Later, he had an unusual pancreatic tail tumor as the first presentation of disease metastasis which was proven by surgical resection one year later. Conclusion: Although mesenchymal chondrosarcoma locates mainly in the axial skeletal system, extra-skeletal soft tissue or organ involvement might be seen occasionally. Active surveillance with multidisciplinary team management could significantly prolong survival outcomes.

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Section: Discussionmentioning

confidence: 99%

“…The highest incidence is in the second and third decades of life [ 2 ]. Due to the few cases published until now [ 4 ], we present a case of mesenchymal chondrosarcoma with unusual distant pancreatic metastasis as a recurrent presentation.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case Report of Mesenchymal Chondrosarcoma with Pancreatic Metastasis

Chen

Chou

2022

Medicina

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“…explored, given the limited number of cases. Reports of pancreatic metastasis of mesenchymal chondrosarcoma remain scarce, 3,4 and treatment outcomes remain elusive.…”

Section: Introductionmentioning

confidence: 99%

Repeated robotic pancreatectomy for recurrent pancreatic metastasis of mesenchymal chondrosarcoma: A case report

Hayashida

Ikenaga

Nakata

et al. 2023

Asian J Endoscop Surgery

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Mesenchymal chondrosarcoma is a rare subset of sarcomas accounting for 3%–10% of all cases of chondrosarcomas. Radical resection is the only curative strategy, even in patients with metastatic tumors. However, data regarding treatment strategies remain limited owing to the small number of cases. Herein, we report a patient who underwent repeated robotic pancreatectomy for recurrent pancreatic metastasis originating from extraskeletal mesenchymal chondrosarcoma of the pelvis. First, robotic pancreaticoduodenectomy with a reconstruction of pancreaticogastrostomy was performed for synchronous pancreatic metastasis 5 months after the primary resection of mesenchymal chondrosarcoma. Ten months after robotic pancreaticoduodenectomy, tumor recurrence was observed at the tail end of the pancreas, which was removed by reperforming robotic distal pancreatectomy. Given the precise tissue manipulation that can be achieved with robotic articulated forceps, the peripheral splenic artery and pancreas were easily isolated and divided in close proximity to the tumor. The central part of the pancreas was preserved. Robotic surgery allowed safe and effective resection of the reconstructed remnant pancreas. The patient survived for 28 months after primary tumor resection. Repeated pancreatectomy with minimally invasive techniques is a feasible and curative treatment for metastatic mesenchymal chondrosarcoma.

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“…The classic histologic finding of MCs is a biphasic tumor composed of sheets and irregular islands of hyaline cartilage or branching thin-walled vasculature, whereas the cartilage component contains hypertrophic chondrocytes with distinct nuclei but without pleomorphism. 2 However, despite the protracted clinical course, it is characterized by developing metastases and local recurrence at a high rate and finally high mortality. 3 We describe a clinical case of female suffering from MC who developed a single pancreatic metastasis 7 years after the initial diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic metastasis of mesenchymal chondrosarcoma

et al. 2020

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Mesenchymal chondrosarcoma is an aggressive tumor with chondrogenic differentiation that typically develops in skeletal sites, such as craniofacial bones, ribs, ilium, femur, and the vertebrae. It counts less than 3% of primary chondrosarcomas, and about a third of these tumors develop extraskeletal sites such as the meninges, and soft tissue. We present a case of a 53-year-old female, that was diagnosed with mesenchymal chondrosarcoma in the left thigh and submitted to surgical excision. The patient's case was evaluated by a multidisciplinary team, and it was decided to maintain vigilance. In the 5 years, follow-up presented several pulmonary metastases that were submitted to pulmonary resections. Two years later, during imaging control, an abdominal computed tomography (CT) scan was performed and revealed a pancreatic mass of 3 centimeters, located in the pancreatic tail. The patient was submitted to an explorative laparoscopy and a distal pancreatectomy was performed. The biopsy gave the definitive result of the metastasis of mesenchymal chondrosarcoma.

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Mesenchymal chondrosarcoma metastasising to the pancreas

Cited by 7 publications

References 22 publications

A Rare Case Report of Mesenchymal Chondrosarcoma with Pancreatic Metastasis

A Rare Case Report of Mesenchymal Chondrosarcoma with Pancreatic Metastasis

Repeated robotic pancreatectomy for recurrent pancreatic metastasis of mesenchymal chondrosarcoma: A case report

Pancreatic metastasis of mesenchymal chondrosarcoma

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