Mesenchymal Chondrosarcoma, Clinicopathological Characteristics of an Uncommon Tumor

Raza, Muhammad; Hussain, Mudassar; Uddin, Nasir; Akhter, Noreen; Hassan, Usman

doi:10.4172/2157-7099.1000505

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…Nevertheless, the absence of cartilage in the biopsy sample might lead to confusion with other small rounds, blue‐cell tumors, such as Ewing's sarcoma, lymphoma, neuroblastoma, small‐cell osteosarcoma, and desmoplastic small round cell tumor. 21 Both mature cartilage cells and round cells were found in the biopsy of the case being discussed, indicating a biphasic pattern. Having both tissues simplified the diagnosis for us, but the tissue may only represent the tumor's round cell component; in these cases, further workup is required for accurate interpretation.…”

Section: Discussionmentioning

confidence: 90%

“…MCS has a remarkable biphasic pattern, and the diagnosis is simple if both portions are collected. Nevertheless, the absence of cartilage in the biopsy sample might lead to confusion with other small rounds, blue‐cell tumors, such as Ewing's sarcoma, lymphoma, neuroblastoma, small‐cell osteosarcoma, and desmoplastic small round cell tumor 21 . Both mature cartilage cells and round cells were found in the biopsy of the case being discussed, indicating a biphasic pattern.…”

Section: Discussionmentioning

confidence: 95%

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Extraskeletal mesenchymal chondrosarcoma arising from soft tissues: A rare case report

et al. 2023

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BackgroundChondrosarcomas are an exceedingly rare form of cancer, impacting only a few individuals per million. Among chondrosarcomas, a small fraction belongs to the mesenchymal sub‐type. Furthermore, only one‐third of mesenchymal chondrosarcomas manifest in extraskeletal locations.CaseA 38‐year‐old woman was referred by a midwife after experiencing pain in the right upper quadrant of her right breast for 2 months. The mass had been palpable for 1 week before the initial assessment. According to radiological evaluations, the tumor is outside breast tissue and not connected to the bones. Hence, a biopsy of the mass is done. The biphasic morphology of the tumor during pathological evaluation, in addition to immunohistochemistry testing, confirms the diagnosis of extraskeletal mesenchymal chondrosarcoma (EMCS). Finally, the mass was surgically removed, and 6 months of chemotherapy were administered to the patient.ConclusionGiven the tumor's rarity and the lack of established guidelines, diagnosing EMCS can be challenging and prone to errors. As such, meticulous sampling, along with precise pathological and imaging investigations, is imperative to accurately establish the diagnosis of these tumors.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Extraskeletal mesenchymal chondrosarcoma arising from soft tissues: A rare case report

et al. 2023

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“…MCS is a rare type of CS which was described as a biphasic tumour comprising of spindle cell mesenchyme interspread with areas of chondroid differentiation 3 5–12. The jaw bones are among the favourite site for MCS 7–13. This tumour is malignant in nature and is histogenetically originated from mature cartilaginous tissue 14.…”

Section: Discussionmentioning

confidence: 99%

“…This rare tumour has been well known for its aggressive nature with an inclination for late recurrence and metastasis 3 6. The peak age incidence is in the second or third decades of life and the most common locations are craniofacial and lower extremity bones, followed by ribs and chest wall 10. The maxilla and mandible are among the common sites of involvement of MCS, followed by the vertebrae, the ribs, the pelvis and the humerus 11.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal chondrosarcoma of maxilla in paediatric patient

et al. 2019

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Chondrosarcoma (CS) is a malignant tumour of long and flat bone characterised by the formation of cartilage. Mesenchymal chondrosarcoma (MCS) is a rare subtype of CS that is more aggressive and may lead to erroneous diagnosis in a limited biopsy. The diagnosis is mainly based on the histopathological appearance of biphasic pattern of undifferentiated small round cells separated by islands of well-differentiated hyaline cartilage. We report a case of 13-year-old boy who initially presented with gum swelling and the biopsy result suggested a benign fibrous lesion. Following an extensive lesion shown in radiologic findings, the tumour excision was done and finally was diagnosed as an MCS of the maxilla. The patient was given postoperative chemotherapy (EURO-EWING 99 regimen), and now on regular follow-up for monitoring of local recurrence or tumour metastasis.

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Primary Soft Tissue Chondrosarcoma

Crawford¹

2021

Chondrosarcoma

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Mesenchymal Chondrosarcoma, Clinicopathological Characteristics of an Uncommon Tumor

Cited by 3 publications

References 26 publications

Extraskeletal mesenchymal chondrosarcoma arising from soft tissues: A rare case report

Extraskeletal mesenchymal chondrosarcoma arising from soft tissues: A rare case report

Mesenchymal chondrosarcoma of maxilla in paediatric patient

Primary Soft Tissue Chondrosarcoma

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