Mesenchymal-Cel Proliferation in Liver Disease of the Alcoholic

Leevy, Carroll M.; tenHove, Willem; Howard, Maceo M.

doi:10.1001/jama.1964.03060210048011

Cited by 22 publications

(3 citation statements)

References 6 publications

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“…Vascular malformations may evoke focal nodular hyperplasia with bile ductules between fibrous septa and two-cell-thick hepatocyte plates. Metabolic disorders associated with chronic liver damage such as hemochromatosis [16] and ·-antitrypsin deficiency [17] are accompanied by a high incidence of malignancy.…”

Section: Clinical Studiesmentioning

confidence: 99%

Abnormalities of Liver Regeneration: A Review

Leevy¹

1998

Dig Dis

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Structural and functional changes during liver regeneration have been studied extensively in experimental animals following partial hepatectomy or hepatic injury induced by noxious substances. These observations have been extended to evaluate abnormalities of liver regeneration which contribute to chronic hepatitis, cirrhosis and/or liver cancer in man. This is facilitated by the simultaneous perfusion of flash frozen percutaneous biopsies or explanted liver in an acrylic chamber with tritiated thymidine and proline to evaluate DNA and collagen synthesis, respectively. Such investigations indicate that chronic liver damage is associated with replication of mesenchymal, ductular and parenchymal cells, accompanied by increased fibrogenesis. The regenerative response of the liver after noxious injury in experimental animals and man is associated with the release of cytokines, increase of growth response genes and change in telomerase activity. The ability to monitor morphological, genetic and biochemical parameters provides new information on the kinetics of the reparative process in hepatobiliary disease. Abnormal liver regeneration and its untoward effects including tumorigenesis may be modified by altering nutrients, blocking antigens or receptors, and inhibiting metabolites which regulate cell replication and collagen deposition.

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Section: Clinical Studiesmentioning

confidence: 99%

Abnormalities of Liver Regeneration: A Review

Leevy¹

1998

Dig Dis

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“…Patients with alcoholic hepatitis or alcoholic cirrhosis have an increase in portal pressure, decrease in blood flow and increase in oxygen extraction [45]. These events may be due to reversible mesenchymal cell proliferation, hyperplasia of the endoplasmic reticulum or opening of intrahepatic shunts [46]. The elevated portal pressure leads to esophageal varices; in these instances, medical therapy, consisting of abstinence and a proper diet, may cause normalization of portal pressure and disappearance of varices (Fig.…”

Section: Circulatory Alterationsmentioning

confidence: 99%

Treatment of Liver Disease of the Alcoholic: A Composite Approach

Leevy¹,

Kanagasundaram²,

Smith³

1981

Semin Liver Dis

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“…Gegen letztere Theorie spricht auch die Tatsache, daß die tägliche Harnstoff-N-Ausscheidung bei unseren Fettleberkranken im Normhereich von 10-20 g liegt. Es müssen deswegen Störungen in der Mikrozirkulation in der mit Fett überladenen Leberzelle angenommen werden (10). Auf eine vermehr-te Kopplung von Phenolen an Glucuronsäure weist auch eine Erhöhung der Glucuronidase-Aktivität hin (3).…”

Section: Pathogenese Der Fettleberunclassified

Pathogenese, Klinik und Biochemie der Fettleber

Müting¹,

Fischer²,

Korn³

et al. 1973

Dtsch med Wochenschr

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Unter Fettleber verstehen wir eine Zunahme des Fett-gehaltes der Leber über den normalen Prozentsatz von 2-4% (berechnet auf Leberfeuchtgewicht). S-10% entsprechen einer beginnenden Fettleber, 10-25% einer mäßigen und 20-50% einer schweren Fettleber. Man kann auch den Lipid-und Triglyceridgehalt im Leberpunktatzylinder quantitativ bestimmen (1, 2, 3), was jedoch für klinische Routinezwecke nicht erforderlich ist. Dabei kann die großtropfige Verfettung histologisch in zonaler oder diffuser Verteilung vorliegen (7).Nach dem Stadium kann man mit Kalk (6) die Fettleber in folgender Weise einteilen: Stadium I: generalisierte Fettleber ohne Mesenchymreaktion, Stadium II: Fettleber mit mäßiger bis deutlicher Mesenchymreaktion (Entzündung), Stadium III: beginnende bis komplette Fettzirrhose.

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Mesenchymal-Cel Proliferation in Liver Disease of the Alcoholic

Cited by 22 publications

References 6 publications

Abnormalities of Liver Regeneration: A Review

Abnormalities of Liver Regeneration: A Review

Treatment of Liver Disease of the Alcoholic: A Composite Approach

Pathogenese, Klinik und Biochemie der Fettleber

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