Mesalazine-Induced Aplastic Anemia

Wiesen, Ari; Wiesen, Jonathan; Limaye, Sewanti; Kaushik, Neeraj

doi:10.1038/ajg.2008.164

Cited by 13 publications

(8 citation statements)

References 12 publications

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“…The side effects of mesalazine include hematologic disorders such as agranulocytosis, hemolytic anemia, and AA. Late-onset AA is a rare but potentially fatal adverse effect (11)(12)(13)(14)(15)(16). The onset of mesalazine-induced AA varies from months to years, but a one-year period is usually required to diagnose mesalazine-induced AA.…”

Section: Discussionmentioning

confidence: 99%

“…However, bone marrow recovery is not a rapid process, and additional supportive treatment including G-CSF is sometimes needed ( 11 , 12 ). Four case reports have described utilizing antilymphocyte/antithymocyte globulin therapy (as a monotherapy or combination with CsA) ( 11 , 13 , 15 ), two of which were treated successfully ( 11 , 14 ). Previous case reports have suggested these treatment strategies, but unfortunately, patients frequently develop severe infections due to profound neutropenia, often leading to death ( 13 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

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Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome

et al. 2021

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Cronkhite-Canada syndrome (CCS) is a rare polyposis disorder accompanied by alopecia and onychodystrophy. A 63-year-old man with a history of CCS and repeated embolism developed progressive thrombocytopenia and mild anemia. Laboratory testing, a bone marrow examination, and magnetic resonance imaging of the spine resulted in a diagnosis of concurrent aplastic anemia (AA). Paroxysmal nocturnal hemoglobinuria (PNH)-type cells were detected in a peripheral blood specimen. In addition, human leukocyte antigen (HLA) included DRB1*15:01 and DRB1*15:02. Mesalazine was discontinued in consideration of possible drug-induced pancytopenia. Immunosuppressive therapy ameliorated both the gastrointestinal symptoms of CCS and pancytopenia. A common autoimmune abnormality might underlie both CCS and AA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome

et al. 2021

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“…Symptoms persisted for up to 1 week after discontinuing steroid therapy and improved thereafter. We determined that 5-aminosalicylates used together with steroids may cause serious hematologic disorder, such as aplastic anemia [ 6 ], but it is not likely to cause psychotic symptoms, while azathioprine, also known as an immunomodulator, may cause adverse events, such as pancreatitis or bone marrow suppression [ 7 ], but they also cannot trigger psychotic symptoms. Blood tests, including electrolyte tests, were unremarkable.…”

Section: Discussionmentioning

confidence: 99%

Steroid-induced Psychosis in Adolescent Patient with Crohn’s Disease

Kim

Kang

2020

J Korean Acad Child Adolesc Psychiatry

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Crohn’s disease is a chronic inflammatory disease that involves the upper and lower gastrointestinal tracts, including the oral cavity. For the conventional treatment of inflammatory bowel diseases, steroids are usually used as induction therapy, and azathioprine is used as maintenance therapy. Steroids are associated with various side effects. Under rare circumstances, they can even cause psychotic symptoms, and reports on steroid-induced psychosis in the pediatric population are few. Here, we report the first case of steroid-induced psychosis in a 16-year-old female with Crohn’s disease administered with steroids as induction therapy in South Korea. She showed psychotic symptoms, including auditory hallucination, loosening of association, and idea of reference, after 2 weeks of administering prednisolone 60 mg/day. One week after steroid discontinuation, the patient gradually recovered and was treated with quetiapine. Therefore, pediatricians should be aware of serious psychiatric adverse effects when administering corticosteroids for various indications.

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“…So kommt es unter Azathioprin-therapie regelhaft zu einer Makrozytose. Azathioprin, Sulfasalazin und Mesalazin können in seltenen Fällen zu einer Knochemarkaplasie oder Hämolyse führen [11][12][13]. Bleibt der Grund unklar, sollten ein Differenzialblutbild und eine hämatologische Vorstellung erfolgen.…”

Section: Diagnostikunclassified

Prävention bei chronisch entzündlichen Darmerkrankungen

Tischendorf

Hatting

2020

Der Klinikarzt

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ZUSAMMENFASSUNGPatienten mit chronisch entzündlichen Erkrankungen (CED) wie Morbus Crohn und Colitis ulcerosa haben spezielle Bedürfnisse im Bereich Vorsorge und Prävention. Grunderkrankung und Therapie können in verschiedenen Bereichen zu erhöhter Morbidität führen. Blutbildveränderungen durch chronischen Blutverlust und Substratmangel oder Eisenverwertungsstörungen sind häufig. Steroidtherapie und Malnutrition können zu Osteopenie und Osteoporose führen. Hier sind CED-Patienten, insbesondere im Alter, gefährdet. Das Erkennen von Mangelzuständen und die Optimierung der Therapie sind entscheidend, um hier präventiv tätig zu werden. Gleiches gilt für das Erkennen von Impflücken und die richtige Risikostratifizierung der häufig immunsupprimierten Patienten. Zuletzt ist auch die Tumorvorsorge von Bedeutung, da sowohl durch die Grunderkrankung als auch durch die Therapie ein erhöhtes Malignomrisiko bestehen kann.

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Mesalazine-Induced Aplastic Anemia

Cited by 13 publications

References 12 publications

Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome

Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome

Steroid-induced Psychosis in Adolescent Patient with Crohn’s Disease

Prävention bei chronisch entzündlichen Darmerkrankungen

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