MERS-CoV as an emerging respiratory illness: A review of prevention methods

Baharoon, Salim; Memish, Ziad A.

doi:10.1016/j.tmaid.2019.101520

Cited by 75 publications

(74 citation statements)

References 118 publications

(203 reference statements)

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“…Other Betacoronaviruses before have caused epidemics over the last two decades in Asia, as is the case of SARS-CoV in [2002][2003] in China [10,15,16], and later with the Middle East Respiratory Syndrome (MERS-CoV) in 2012-2013 in Saudi Arabia [17][18][19][20]. As expected, several similarities and differences in the epidemiology, clinical features, and management of SARS, MERS, and COVID have been identified [3][4][5][20][21][22][23].…”

Section: Rationalementioning

confidence: 73%

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

Rodríguez‐Morales

Cardona-Ospina

Gutiérrez‐Ocampo

et al. 2020

Travel Medicine and Infectious Disease

2,001

124

1,591

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Methods:We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95%CI).Results: 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 40.8-74.4%) and dyspnea (45.6%, 10.9-80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock. Some 13.9% (95%CI 6.2-21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR).Conclusion: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of over 13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19.

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Section: Rationalementioning

confidence: 73%

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

Rodríguez‐Morales

Cardona-Ospina

Gutiérrez‐Ocampo

et al. 2020

Travel Medicine and Infectious Disease

2,001

124

1,591

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“…Coronaviruses are enveloped non-segmented positive-sense RNA viruses belonging to the family Coronaviridae (subfamily Orthocoronavirinae) and the order Nidovirales and broadly distributed in humans and other mammals [1,2], including four genuses, Alphacoronavirus, Betacoronavirus, Deltacoronavirus, and Gammacoronavirus. Although most human coronavirus infections are mild, the previous epidemics of two betacoronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV) [3][4][5][6][7] and Middle East respiratory syndrome coronavirus (MERS-CoV) [8][9][10][11], have caused more than 10,000 cumulative cases in the past two decades, with mortality rates of 10% for SARS-CoV and 37% for MERS-CoV. The coronaviruses already identified might only be the tip of the iceberg, with potentially more novel and severe zoonotic events to be revealed [1].…”

Section: Introductionmentioning

confidence: 99%

Coronavirus infections reported by ProMED, February 2000–January 2020

Bonilla-Aldana

Holguin-Rivera

Cortés-Bonilla

et al. 2020

Travel Medicine and Infectious Disease

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“…The emergence of coronaviruses infections with high impact in public health began in 2002-2003 with the SARS outbreak [12,13] and in 2012, MERS-CoV, another highly-pathogenic coronavirus which still circulates in the Middle East and causes severe respiratory disease [14,15] was reported.…”

Section: Introductionmentioning

confidence: 99%