Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum

Xu, Ya‐Qiong; Liu, Haishan; Zhu, Guoliang; Fu, Peng; Wang, Liping; Zhu, Weiming

doi:10.3390/md16100363

Cited by 22 publications

(16 citation statements)

References 37 publications

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“…was investigated. Compounds 76, 81, 85, and 87 exhibited inhibitory potential towards the Saccharomyces cerevisiae expressed human-sourced α-glucosidase recombinant with IC 50 s 0.37, 0.32, 0.036, and 0.026 mM, respectively compared to acarbose (IC 50 0.47 mM)[103]. Compounds 165, 167, 174, and 218 biosynthesized by Leptosphaena maculans did not show any inhibitory effects against α-glucosidase…”

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confidence: 94%

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

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Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.

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confidence: 94%

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

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“…The inhibitions of the compounds against α-glucosidase from Saccharomyces cerevisiae were assayed by reported method (Xu et al, 2018). The testing compounds were dissolved in dimethyl sulfoxide (DMSO) to obtain stock solution (10 mM) and then diluted into the concentrations by PBS (pH 6.8), while α-glucosidase (2.0 U/mL, Sigma), 4-nitrophenyl-α-Dglucopyranoside (PNPG, 2.5 mM, Macklin), Na 2 CO 3 (0.2 M), and acarbose (2.5 mg/mL, Sigma) were directly dissolved in PBS.…”

Section: α-Glucosidase Inhibitory Assays α-Glucosidase Inhibitions Inmentioning

confidence: 99%

p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities

Wang

et al. 2021

Front. Microbiol.

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One new (1) and fifteen known (2–16) p-terphenyls were isolated from a solid culture of the endophytic fungus Aspergillus sp. GZWMJZ-055 by adding the leaves of its host Eucommia ulmoides. Furthermore, nine p-terphenyls (17–25) were synthesized from the main compounds (5–7), among which derivatives 18, 19, 21, 22, and 25 are new p-terphenyls. Compounds 15 and 16 were also, respectively, synthesized from compounds 6 and 7 by oxidative cyclization of air in the presence of silica gel. These p-terphenyls especially those with 4,2′,4″-trihydroxy (4–7, 20, 21) or 4, 4″-dihydroxy-1,2,1′,2′-furan (15, 16) substituted nucleus, exhibited significant antioxidant and α-glucosidase inhibitory activities and lower cytotoxicity to caco-2 cells. The results indicated their potential use as lead compounds or dietary supplements for treating or preventing the diabetes.

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“…Studies of the fungus Myrothecium sp. OUCMDZ-2784 associated with the salt-resistant medicinal plant, Apocynum venetum (Apocynaceae) (the estuary of Yellow River, China), afforded four new meroterpenoids, myrothecisins A-D (366-369), which displayed a weak α-glucosidase inhibitory effect (IC 50 = 0.50, 0.66, 0.058, and 0.20 mM vs. 0.47 mM for acarbose) [117].…”

Section: Aspergillus Spmentioning

confidence: 99%

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

Jiang

Guo

et al. 2020

Marine Drugs

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Marine-derived fungi are a significant source of pharmacologically active metabolites with interesting structural properties, especially terpenoids with biological and chemical diversity. In the past five years, there has been a tremendous increase in the rate of new terpenoids from marine-derived fungi being discovered. In this updated review, we examine the chemical structures and bioactive properties of new terpenes from marine-derived fungi, and the biodiversity of these fungi from 2015 to 2019. A total of 140 research papers describing 471 new terpenoids of six groups (monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, triterpenes, and meroterpenes) from 133 marine fungal strains belonging to 34 genera were included. Among them, sesquiterpenes, meroterpenes, and diterpenes comprise the largest proportions of terpenes, and the fungi genera of Penicillium, Aspergillus, and Trichoderma are the dominant producers of terpenoids. The majority of the marine-derived fungi are isolated from live marine matter: marine animals and aquatic plants (including mangrove plants and algae). Moreover, many terpenoids display various bioactivities, including cytotoxicity, antibacterial activity, lethal toxicity, anti-inflammatory activity, enzyme inhibitor activity, etc. In our opinion, the chemical diversity and biological activities of these novel terpenoids will provide medical and chemical researchers with a plenty variety of promising lead compounds for the development of marine drugs.

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Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum

Cited by 22 publications

References 37 publications

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

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