Merkel-Zell-Karzinom

Kleffner, F.; Schürholz, J; Burckhardt, S.; Mauch, Cornelia; Schlaak, Max

doi:10.1007/s00105-001-0318-4

Cited by 11 publications

(7 citation statements)

References 44 publications

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“…These data are also consistent with previous studies. 4,24 Of the six tumors that showed no genomic aberrations, five (83%) were found in the small tumors group. Five patients (55%) with small tumors (size o2 cm) showed no DNA changes.…”

Section: Discussionmentioning

confidence: 99%

Recurrent DNA copy number changes revealed by comparative genomic hybridization in primary Merkel cell carcinomas

et al. 2004

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Comparative genomic hybridization (CGH) was used to search for gains, high-level amplifications and losses of DNA sequences along all chromosome arms in 19 primary Merkel cell carcinomas (MCC). Extensive genetic aberrations, with a mean value of 5.571.1 changes per tumor were detected in 13 out of the 19 samples analyzed. Our CGH results reveal several new and other previously known chromosomal regions that are involved in the pathogenesis of MCC. The majority of the alterations were gains of whole chromosomes or whole chromosome arms. Compared to losses, the frequency of DNA copy number gains was two-fold. DNA sequence copy number gains were most common in chromosomes 6 (42%), 1 (37%), and 5 (32%). The most frequent minimal common regions of gains were 6pterqter (42%), 1q11q31 (32%), and 5p (32%). No recurrent high-level amplifications were observed. High-level amplifications of small chromosomal regions were found in four samples out of the 19 tumors analyzed (21%). Amplifications affected 1q22q24 (5%), 4p (5%), and 5p (5%). Losses most frequently affected chromosomes 13 (21%) and 4 (16%). Minimal common regions with the most frequent losses were 13q13q31 (21%), 4q (16%), and 16q (11%). No significant statistical correlation between genomic aberrations and clinicopathological factors was revealed, despite the fact that there was an obvious tendency towards it. Primary MCC expressing DNA alterations were predominantly distinguished in large tumors, and risk of metastatic dissemination was three-fold compared to tumors with no DNA alterations.

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Section: Discussionmentioning

confidence: 99%

Recurrent DNA copy number changes revealed by comparative genomic hybridization in primary Merkel cell carcinomas

et al. 2004

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“…In our group of patients, a lower survival percentage was observed, since 5 out of 7 patients died within 1.5 years from diagnosis. MCC, as an aggressive tumor, has a high reported probability of local recurrence (30-50%), while in 50-80% of the cases the tumor produces metastases in the cervical lymph nodes, and in 55% of the cases distant metastases [6,27,28]. Only 1 of our patients had a local and cervical lymph node recurrence, while 5 patients showed distant metastases.…”

Section: Discussionmentioning

confidence: 73%

Merkel Cell Carcinoma: Report of Seven Cases

Karapantzos

Tsaroucha

Polychronidis

et al. 2003

ORL

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Merkel cell carcinoma (MCC) is an infrequent, highly malignant, primary skin tumor derived from neuroendocrine cells. Most MCCs occur in elderly individuals, on sun-exposed areas of the body, with the head and neck being the most common sites. We present 7 patients (2 male and 5 female, age 45–80 years) suffering from MCC and treated between 1993 and 2000. All tumors were located on the head and neck and varied from 0.9 to 2.3 cm in size. Five of the patients had stage II disease, 1 patient had stage Ia disease and 1 patient had stage III disease. Six of the patients had positive regional lymph nodes. All patients had local excision of the tumor. Six of them also had lymph node dissection and in 5 of them a superficial parotidectomy was performed. Five patients received adjuvant radiotherapy and 3 of them also received chemotherapy. Local and cervical lymph node recurrence was observed in only 1 patient. Metastases occurred in 5 patients. One patient died within 10 days for other reasons. The patient with the stage III tumor had a survival of 7 months. The other 5 patients had survivals varying from 15 to 54 months. MCC is a skin tumor with very poor prognosis and high recurrence and metastatic rates. Its treatment is still under discussion. Radical excision of the tumor is the main method of treatment. Selective lymph node dissection is suggested. Superficial parotidectomy seems necessary, especially if the tumor is on the auricle. Adjuvant radio- and chemotherapy may extend survival in case of small-size tumors.

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“…Eminent wichtig ist es, bereits bei der Operationsplanung die Option auf eine nachfolgende Strahlentherapie mit einzubeziehen. Daher sollte auf Transplantate und grö-ßere Lappenplastiken möglichst verzichtet werden, sofern dabei die vollständi-ge Exzision des Tumors gewährleistet bleibt [19]. Eine elektive Lymphadenektomie sollte heute wegen der teils erheblichen Nebenwirkungen nicht mehr erfolgen, insbesondere da ihr therapeutischer Vorteil nicht belegt ist [32].…”

Section: Primärtumor Und Lokalrezidiv (Stadium I) Operationunclassified

Merkel-Zell-Karzinom

Toberer

Werchau

Bischof

et al. 2011

Chirurg

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Merkel cell carcinoma (MCC) or neuroendocrine carcinoma of the skin, is a rare and highly aggressive tumor which typically develops in chronically sun-damaged skin in aged or immunosuppressed patients. The clinical course is characterized by early local recurrence and lymphatic metastases. The current discussion on the etiology of MCC is dominated by the recently discovered Merkel cell polyoma virus (MCPyV). Apparently, MCPyV infection takes place early in life and the virus can also be found in healthy tissue. Possibly, a mutation of the viral genome is responsible for the development of the tumor. The 5 year survival rate of patients with primary MCC is only 30-40% after surgical therapy alone but can increase to about 75% after additional adjuvant radiotherapy. In cases with lymphatic or distant metastases various chemotherapy protocols in addition to operative and radiation therapy analogous to those for small cell lung cancer therapy have been found to be effective. Nevertheless, very high recurrence rates are typical in patients with distant metastases. Thus, MCC is regarded as chemosensitive but not chemocurable.Patients with MCC should be treated with an aggressive but individually adapted concept. The consequent integration of radiotherapy into the therapeutic approach can improve the prognosis.

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Merkel-Zell-Karzinom

Cited by 11 publications

References 44 publications

Recurrent DNA copy number changes revealed by comparative genomic hybridization in primary Merkel cell carcinomas

Recurrent DNA copy number changes revealed by comparative genomic hybridization in primary Merkel cell carcinomas

Merkel Cell Carcinoma: Report of Seven Cases

Merkel-Zell-Karzinom

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