Merkel cell tumor of the skin treated with localized radiotherapy: are widely negative margins required?

Trombetta, Mark; Packard, Matthew; Velosa, Claudia; Silverman, Jan F.; Werts, Day; Parda, David S.

doi:10.4081/rt.2011.e12

Cited by 8 publications

(2 citation statements)

References 28 publications

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“…Novel therapies use of imiquimod (an immune modulator that activates TLR7 cells on the skin surface) cream plus radiotherapy (5040 cGy in 28 fractions) has been used anecdotally as has hyperthermia with radiotherapy with limited success. Both groups demonstrated local control, however adjuvant radiotherapy was delivered in both cases and the margins of resection were histologically negative (17).…”

Section: Discussionmentioning

confidence: 97%

Merckel cell carcinoma of the skin treated with somatostatin analogue and mTOR inhibitor exhausted after primary surgery, adjuvant radiotherapy and palliative chemotherapy

Slováček¹

2014

BLL

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Merkel cell carcinoma is a highly aggressive neuroendocrine skin tumor. This type of tumor is primarily based on Merkel cells located in the basal layer of the epidermis. The tumor occurs predominantly in elderly individuals (average age 69 years) and has a strong tendency to local recurrence and locoregional metastasis. Diagnosis of the tumor is based on histological and immunohistochemical examination. The therapy is radical surgery followed by adjuvant radiotherapy to the site of the primary tumor and regional lymph nodes. The authors describe a case report of Merkel cell carcinoma of the skin treated with somatostatin analogue and mTOR inhibitor exhausted after primary surgery and adjuvant radiotherapy and paliative chemotherapy (Fig. 2, Ref. 17). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 97%

Merckel cell carcinoma of the skin treated with somatostatin analogue and mTOR inhibitor exhausted after primary surgery, adjuvant radiotherapy and palliative chemotherapy

Slováček¹

2014

BLL

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“…Other studies show equal results for R0 resection using Mohs surgery and wide-local excision (25). Due to the good radiosensitivity of MCC cells, smaller excision margins are discussed (26). Adjuvant RT improves local control and survival (2).…”

Section: Discussionmentioning

confidence: 99%

Outcome of Combined Treatment of Surgery and Adjuvant Radiotherapy in Merkel Cell Carcinoma

Fiedler¹,

Vordermark²

2018

Acta Derm Venerol

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In recent analyses of Merkel cell carcinoma, prognosis is poor even in stages I and II. We performed a monocentric retrospective study of 37 consecutive cases with Merkel cell carcinoma stage I to III treated with a combination of surgery and adjuvant radiation to evaluate progression-free and overall survival. The median primary tumour diameter was 17.9 mm. Cases consisted of 31 primary tumours, of which 13 had negative sentinel lymph node biopsy (IA n = 10 and IIA n = 3) and 18 no sentinel lymph node biopsy (IB n = 15 and IIB n = 3), 2 tumours with positive sentinel lymph node biopsy (IIIA) and 4 with local macrometastasis (IIIB). The median age was 71 years and the median follow-up was 60.4 months. The 5-year progression-free survival was 83.8% and 5-year disease-specific survival was 95.7% (overall survival 93.0%). So far, our results show a high survival rate with combined treatment of surgery and adjuvant radiotherapy in early tumour stages of Merkel cell carcinoma.

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Skin: The Case for Altered Fractionation in the Treatment of Both Malignant and Benign Conditions

Fontanesi

Kopitzki

Zekman

2017

Alternate Fractionation in Radiotherapy

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Merkel cell tumor of the skin treated with localized radiotherapy: are widely negative margins required?

Cited by 8 publications

References 28 publications

Merckel cell carcinoma of the skin treated with somatostatin analogue and mTOR inhibitor exhausted after primary surgery, adjuvant radiotherapy and palliative chemotherapy

Merckel cell carcinoma of the skin treated with somatostatin analogue and mTOR inhibitor exhausted after primary surgery, adjuvant radiotherapy and palliative chemotherapy

Outcome of Combined Treatment of Surgery and Adjuvant Radiotherapy in Merkel Cell Carcinoma

Skin: The Case for Altered Fractionation in the Treatment of Both Malignant and Benign Conditions

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