Merkel cell neoplasms

Sidhu, Gurdip S.; Feiner, Helen; Flotte, Thomas J.; Mullins, James D.; Schaefler, Katalin; Schultenover, Stephen J.

doi:10.1097/00000372-198000220-00001

Cited by 141 publications

(20 citation statements)

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“…Squamous differentiation There have been over 600 cases of MCT of all sites pub-has also been noted in four cases of MCT from nonvulvar sites lished since the original case report in 1972 [1, 2]. Only 9 [11, [13][14][15]. No case of MCT from any site has been described cases, including the present case, have been reported on the with both glandular and squamous differentiation.…”

Section: Discussionmentioning

confidence: 57%

Vulvar Merkel Cell Tumor with Glandular and Squamous Differentiation

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et al. 1996

Gynecologic Oncology

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Section: Discussionmentioning

confidence: 57%

Vulvar Merkel Cell Tumor with Glandular and Squamous Differentiation

Scurry

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et al. 1996

Gynecologic Oncology

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“…Both lesions frequently fail surgery and radiotherapy [3,4], and combination chemotherapy can be of benefit. For patients with metastatic salivary gland carcinomas, a 46~ response rate was obtained with a regimen of combined cyclophosphamide, doxorubicin and cisplatin [5].…”

Section: Discussionmentioning

confidence: 99%

Response of metastatic adenoid cystic carcinoma and Merkel cell tumor to high-dose Melphalan with autologous bone marrow transplantation

1992

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Two patients with metastatic spread of unusual tumors responded to treatment with high-dose Melphalan and autologous bone marrow transplant. One patient had adenoid cystic carcinoma of a minor salivary gland and the other had Merkel cell tumor of the scalp. Both patients had undergone prior surgery and radiotherapy, but later relapsed with distant metastases. Both patients had progression of their disease despite conventional and salvage chemotherapy. Treatment with high-dose Melphalan and autologous bone marrow transplant resulted in partial responses for both patients. High-dose Melphalan should be considered for therapy earlier in the course of patients with these unusual cancers.

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“…It is commonly seen in older patients (mean age 60) 4 . Aggressive therapy is advised early in the course of treatment, as more than two thirds of cases develop local or lymphatic metastases, and 20% die as a result of the disease 5 …”

Section: Introductionmentioning

confidence: 99%

Merkel Cell Carcinoma: A Challenge

Stawowy

Krull

Maeda

1986

The Journal of Dermatologic Surgery and Oncology

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A 70-year-old man presented with an enlarging, recurrent tumor of the left buttock which, on initial biopsies, was interpreted as a histiocytic malignant lymphoma. Further biopsies showed numerous monomorphic, hyperchromatic, noncohesive cells, arranged in compact sheets, throughout the dermis, the fat, and the underlying muscle. Neuron specific enolase stain for neuroendocrine granules was positive. Electron microscopy showed cytoplasmic perinuclear microfilaments and round membrane-bound dense core granules. The histologic, enzymatic, and ultrastructural findings confirmed the diagnosis of Merkel cell carcinoma. Early diagnosis and treatment are imperative for a favorable outcome.

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Merkel cell neoplasms

Cited by 141 publications

References 0 publications

Vulvar Merkel Cell Tumor with Glandular and Squamous Differentiation

Vulvar Merkel Cell Tumor with Glandular and Squamous Differentiation

Response of metastatic adenoid cystic carcinoma and Merkel cell tumor to high-dose Melphalan with autologous bone marrow transplantation

Merkel Cell Carcinoma: A Challenge

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