Merkel cell carcinoma with squamous and sarcomatous differentiation

Hwang, June; Alanen, Ken W.; Dabbs, Kelly; Danyluk, J. M.; Silverman, Sveta

doi:10.1111/j.1600-0560.2007.00917.x

Cited by 37 publications

(20 citation statements)

References 10 publications

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“…Other skin carcinomas that sometimes feature squamous differentiation include Merkel cell carcinoma (MCC), porocarcinoma, and sebaceous carcinoma [23, 27, 28]. This is likely a manifestation of divergent differentiation of the tumor or varied differentiation of tumor stem cells.…”

Section: Other Malignant Tumors That Mimic Primary Cutaneous Sccmentioning

confidence: 99%

Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation

Tan

et al. 2013

Journal of Skin Cancer

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Squamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy. On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinization, and invasive features. Diagnostic challenges may occasionally arise, especially in the setting of small punch biopsies or superficial shave biopsies, where only part of the lesion may be assessable by the pathologist. Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma. The careful application of time-honored diagnostic criteria, close clinicopathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis. This review aims to present the key differential diagnoses of SCC, to discuss common diagnostic pitfalls, and to recommend ways to deal with diagnostically challenging cases.

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Section: Other Malignant Tumors That Mimic Primary Cutaneous Sccmentioning

confidence: 99%

Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation

Tan

et al. 2013

Journal of Skin Cancer

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“…[3] The neoplastic cells were initially thought to arise from the Merkel cells; however, origin from a stem cell, able to differentiate along different cell lines, is favored. [4] Moreover the tumor has been recognized in many extracutaneous sites like esophagus and salivary glands. [2] Incidence peaks in 7 th to 9 th decades of life; however, younger age group is not exempted.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine tumor of vulva: A case report and review of literature

et al. 2010

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Neuroendocrine tumor (Merkel cell carcinoma-MCC) of the vulva is a very rare entity with less than 15 cases reported in the English literature. It is known for its aggressive behaviour and propensity for early dissemination. The actual cell of origin and etiology of this disease is controversial. In absence of any definite guidelines for management (due to its rarity), extrapolation of data from extra-vulvar MCC seems logical. We present a case of vulvar neuroendocrine tumor who presented at a locally advanced stage.

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“…Sirikanjanapong et al [26] reported a case of intraepidermal and dermal MCC with squamous cell carcinoma in situ. Hwang et al [27] reported a case of MCC with squamous and sarcomatous differentiations. Jones et al [28] reported a case showing a development of cutaneous NEC mixed with squamous cell carcinoma in erythema.…”

Section: Discussionmentioning

confidence: 99%

Primary squamous neuroendocrine carcinoma of the skin: A case report with immunohistochemical study

Terada

2016

CRCP

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Primary neuroendocrine carcinoma (NEC) except for Merkel cell carcinoma has rarely been reported in the skin. Herein reported is a unique case of a primary cutaneous NEC with histological features of squamous cell carcinoma (SCC) with high cellular anaplasia; the tumor is called "squamous NEC" in this report. A 77-year-old man presented with a skin tumor measuring 0.7 cm × 0.8 cm × 0.7 cm of the right second finger. A biopsy showed invasive malignant epithelial cells with keratinization. The carcinoma cells were continuous with epidermis, and showed high cellular anaplasia. No apparent lympho-vascular permeations were seen. The pathological diagnosis was poorly differentiated SCC. Because the histological features were unusual, an immunohistochemical study was performed. The carcinoma cells were positive for cytokeratin (CK) AE1/AE3, CK34BE12, CK5/6, neuron-specific enolase (NSE) (positive percentage (PP) = 70%), chromogranin (PP = 95%), synaptophysin (PP = 95%), NCAM (PP = 20%), p63, p40, S100 protein (Langerhans cells), and Ki-67 (labeling index (LI) = 98%). The carcinoma cells were negative for CK7, CK8, CK9, CK14, CK18, CK19, CK20, CK CAM5.2, smooth muscle actin, vimentin, desmin, HMB45, p53, CD45, TTF-1, HCG, and surfactant apo-protein. Because the skin SCC showed neuroendocrine features and the neuroendocrine cells exceeded 50% of the total tumor cell population, a diagnosis of squamous NEC was made. The histological features, NEC features, high anaplasia, and high Ki-67 labeling index (LI = 98%) suggested poor prognosis. Systemic investigations using CT, MRI, PET, and upper and lower gastrointestinal endoscopy revealed no tumors except for the finger tumor. No lympho-adenopathy was seen. The outcome seemed not good. The tumor of the finger was difficult for operation. Wide excision or finger amputation is considered.

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Merkel cell carcinoma with squamous and sarcomatous differentiation

Cited by 37 publications

References 10 publications

Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation

Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation

Neuroendocrine tumor of vulva: A case report and review of literature

Primary squamous neuroendocrine carcinoma of the skin: A case report with immunohistochemical study

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