Merkel cell carcinoma occurring in renal transplant patients

Urbatsch, Amy; Sams, W. Mitchell; Urist, Marshall M.; Sturdivant, Rachel L.

doi:10.1016/s0190-9622(99)70366-x

Cited by 50 publications

(33 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence of MCC has been reported to increase steadily during recent years (11,12). MCC occurs more often in Caucasian males and is associated with sun exposure and immunosuppression (7,13).…”

Section: Introductionmentioning

confidence: 99%

Frequent Detection of Merkel Cell Polyomavirus in Human Merkel Cell Carcinomas and Identification of a Unique Deletion in the VP1 Gene

et al. 2008

View full text Add to dashboard Cite

Merkel cell carcinoma (MCC) is a rare but very aggressive human malignancy of the elderly or immunosuppressed patients. Recently, the clonal integration of a new human polyoma virus, which was termed Merkel cell polyomavirus (MCPyV), has been reported in 8 of 10 MCC patients. In the present study, we studied the formalin-fixed and paraffinembedded tissue specimens of 39 MCC for the presence of MCPyV by PCR. We applied four different primer sets directed against the large T antigen and the VP1 gene of MCPyV. We were able to detect MCPyV in 77% (n = 30) of MCC as confirmed by sequence analyses of the PCR products. Sequence analyses showed only minor nucleotide changes compared with the previously published MCC sequences. In addition, one patient revealed the amplification of two PCR products using PCR primers directed against the VP1 gene. Sequence analyses confirmed the presence of the expected 351-bp PCR product and in addition a second PCR product of 261 bp containing a unique 90-bp deletion in the VP1 gene, which will lead to a predicted loss of 28 amino acids. The unique 90-bp deletion within the VP1 gene possibly is a result of incomplete viral integration of MCPyV in the MCC. The presence of MCPyV in the majority of MCC tissue specimens in our study strongly underlines a possible role for MCPyV as an etiologic agent in the carcinogenesis of MCC. [Cancer Res 2008;68(13):5009-13]

show abstract

Section: Introductionmentioning

confidence: 99%

Frequent Detection of Merkel Cell Polyomavirus in Human Merkel Cell Carcinomas and Identification of a Unique Deletion in the VP1 Gene

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Hematogenous and/or distant lymphatic metastases ultimately occur in one-third of patients and most frequently involve liver, bone, brain, lung and skin, although metastasis to nearly every organ has been reported. Poor prognostic factors are: occurrence in patients aged over 55 years, location on the head and neck region, size of more than 2 cm, the presence of immunosuppression, advanced stage of disease, more than 10 mitotic figures per single high-power field, small cell size, angiolymphatic invasion, and immunoreactivity for CD44 7,8 . Local recurrence is a major risk factor for further spreading and distant metastases, and worsens the prognosis 4 .…”

Section: Discussionmentioning

confidence: 99%

A Case of Merkel Cell Carcinoma: Treated with Wide Excision and Adjuvant Radiotherapy

et al. 2008

View full text Add to dashboard Cite

“…Zum Todeszeitpunkt war eine ausgedehnte hämatogene Metastasierung nachweisbar, ein lokales Tumorrezidiv lag nicht vor. Das Zeitintervall zwischen Transplantation und Erstmanifestation eines Merkel-Zell-Karzinoms wird mit durchschnittlich 3,5-7,5 Jahren angegeben, die Mortalität mit 35% [17,22,29]. In unserem Fall lag das Zeitintervall zwischen Nierentransplantation und Auftreten des Merkel-Zell-Karzinoms mit 25 Jahren deutlich über dem Durchschnitt und stellt somit eine Besonderheit dar.…”

Section: "Das Merkel-zell-karzinom Ist Bei Organtransplantierten Patiunclassified

“…Umso bemerkenswerter ist, dass sich diese seltene Tumorentität in über 50 Fällen bei Patienten nach Organtransplantation, insbesondere nach Nierentransplantation, manifestiert hat [2,3,4,5,8,17,19,22,29]. Dies spricht dafür, dass auch Merkel-ZellKarzinome in die Reihe der Posttransplantationsneoplasien einzuordnen sind, unter denen Malignome der Haut und Lippe, insbesondere Plattenepithelkarzinome und Basaliome, mit gut 36% am häufigsten sind [7].…”

Section: Introductionunclassified