Merkel cell carcinoma in Scotland 2000-10

Samuel, Robert; Matthews, Allan G.; Holme, S.A.

doi:10.1111/bjd.13869

Cited by 5 publications

(7 citation statements)

References 10 publications

(16 reference statements)

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“…The median age at diagnosis of MCC in NZ is 77 for men and 82 for women. These figures are consistent with other studies in Australia, Europe and North America where the median age is between 75 and 81 years old …”

Section: Discussionsupporting

confidence: 93%

“…The national incidence within Australia is unknown. Other published rates vary from 0.1 to 0.4/100 000 in Europe, and 0.79/100 000 in the United States …”

Section: Discussionmentioning

confidence: 98%

“…A higher proportion of patients with MCC in NZ have distant metastases at the time of diagnosis when compared to Australia and elsewhere in the world. Eighteen per cent of patients have stage IV, distant metastatic disease at time of diagnosis in NZ which is higher than in the USA and Europe, where figures range from 3 to 8% and 15% in Queensland . Due to missing data in the NZCR, a stage could not be assigned to a large proportion of cases; therefore, caution must be practiced when interpreting these results.…”

Section: Discussionmentioning

confidence: 98%

“…Increasing ultraviolet (UV) irradiation has an association with incidence rates of MCC. It is more common in the elderly Caucasian demographic and sun‐exposed areas such as the head and neck . Australia is known to have a high UV index and has reported the highest incidence rates of MCC in the world .…”

Section: Introductionmentioning

confidence: 99%

“…The regional incidence of MCC is variable, with figures ranging from 0.10 to 1.6 per 100 000 population . One study in NZ has published incidence rates of 0.88/100 000 from the period of 2002–2011 .…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and survival of Merkel cell carcinoma in New Zealand: A population‐based study between 2000 and 2015 with international comparison

et al. 2019

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Background/Objectives: Merkel cell carcinomais an aggressive neuroendocrine skin cancer. Australian studies report high incidence and poor survival rates compared internationally. While New Zealand has a comparable UV index and racial composition to Australia, survival outcomes are currently unknown. The role of Merkel cell polyoma virus in oncogenesis of Merkel cell carcinoma is an active area of research. We describe the incidence and survival of Merkel cell carcinoma in New Zealand with correlation to demographic and clinical factors including regional polyoma virus prevalence.Methods: Retrospective study of population-based data from the New Zealand Cancer Registry. Incidence rates were directly standardised to the US standard 2000 population. Survival was investigated using Kaplan-Meier and multivariable Cox regression models.Results: Six hundred and one cases were diagnosed in New Zealand between 2000 and 2015. The overall incidence rate was 0.96/100 000 population. Merkel cell carcinoma is more common in males, elderly and on sun-exposed areas. Eighteen percent of patients were diagnosed with distant metastasis at time of presentation. The overall 5-year survival rate and relative 5-year survival rate were 31% and 45%, respectively. Mortality was 1.9 and 2.5 times higher for stage III and IV disease, respectively, relative to stage I/II disease. Patients over age 80 had twice the mortality compared to those aged 60-69. Conclusions: New Zealand has a high incidence ofMerkel cell carcinoma and poor survival outcomes when compared internationally. We have the highest proportion of distant metastatic disease at time of diagnosis. Further research into the role of nonpolyoma-related Merkel cell carcinoma is warranted to improve Merkel cell carcinoma outcomes in New Zealand and abroad.

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Section: Discussionsupporting

confidence: 93%

“…The national incidence within Australia is unknown. Other published rates vary from 0.1 to 0.4/100 000 in Europe, and 0.79/100 000 in the United States …”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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