Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity

García‐Mesa, Yolanda; Martín-Sanz, Raquel; García‐Piqueras, Jorge; Cobo, Ramón; Muñoz-Bravo, Saray; García‐Suárez, Olivia; Martín‐Biedma, Benjamín; Vega, J.A.; Feito, Jorge

doi:10.3390/jpm12060894

Cited by 2 publications

(1 citation statement)

References 36 publications

(52 reference statements)

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“…In terms of immunohistochemistry, MCC cells are positive for epithelial markers such as CK-CAM5.2, CKAE1-AE3, CK20, CK34BetaE12, BerEP4 and Epithelial membrane Antigen (EMA), PIEZO2 [12], with some cases showing positivity for CK7 along with markers of neuroendocrine differentiation including Chromogranin A (CgA), Synaptophysin (Syn) and CD56 (NCAM1). It is also important to mention that positivity for CK20 is de ned as 'dot-like' and is a reliable speci c sign for the diagnosis of MCC [11,13]. An example of CK20 is reported in Fig.…”

Section: Histopathology and Immunohistochemical Features Of MCCmentioning

confidence: 99%

Mast Cells density in relation to recurrency, lymphovascular Invasion and MCPyV status in Human Merkel Cell Carcinoma: a descriptive study with prognostic implications

Cazzato,

Tamma,

Fanelli

et al. 2024

Preprint

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Merkel cell carcinoma (MCC) is a rare, highly aggressive, primitive neuroendocrine carcinoma of the skin, the origin of which is not yet fully understood. Numerous independent prognostic factors have been investigated in an attempt to understand which are the most important parameters to indicate in the histological diagnostic report of MCC. Of these, mast cells have only been studied in one paper before this one. We present a retrospective descriptive study of 13 cases of MCC, received at the Department of Pathology over a 20-year period (2003–2023 inclusive) on which we performed a study using whole-slide (WSI) morphometric analysis scanning platform Aperio Scanscope CS for the detection and spatial distribution of mast cells, using monoclonal anti-Tryptase antibody and anti-CD34 monoclonal antibody to study the density of microvessels. Furthermore, we performed immunohistochemical reactions for MCPyV to split the study cohort of MCC in related and not-related to MCPyV. We found a statistically significant relationship between mast cell density in samples from patients who had experienced local recurrence/distant metastasis or death from MCC and patients who at follow-up (24 months) had shown no recurrence of disease (7.35 vs 2.5; p = 0.008). Regarding MCPyV status, we described for the first time (to the best of our knowledge) that MCPyV-negative MCC have more density of mast cells respect to MCPyV-positive MCC that are known to behave in less aggressive fashion. Conversely, no significant difference was observed between the median vascular density observed on excisional biopsy of patients experiencing recurrence or metastasis and the median observed on excisional biopsy of patients without recurrence (5.3 vs 1.7; p = 0.18). This paper, despite the sample size (n = 13), supports the inclusion of a semi-quantitative analysis of mast cell distribution and density in the histopathological report of MCC.

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Section: Histopathology and Immunohistochemical Features Of MCCmentioning

confidence: 99%

Mast Cells density in relation to recurrency, lymphovascular Invasion and MCPyV status in Human Merkel Cell Carcinoma: a descriptive study with prognostic implications

Cazzato,

Tamma,

Fanelli

et al. 2024

Preprint

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Combined Merkel Cell Carcinoma and Squamous Cell Carcinoma: A Systematic Review

Ríos-Viñuela,

Mayo-Martínez,

Nagore

et al. 2024

Cancers

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Combined Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC) have classically been regarded as more aggressive than conventional, pure, Merkel cell polyomavirus (MCPyV)-positive MCC. It is still unknown whether combined MCC and SCC are more aggressive than pure, MCPyV-negative MCC, and the origin of both the SCC and MCC elements of these combined tumors has not been elucidated. The main objective of this systematic review was to assess whether combined MCC and SCC tumors are associated with a worse prognosis than pure MCC; the secondary goals were the characterization of the clinical and histopathological features of these combined neoplasms. A total of 38 studies, including 152 patients, were selected for review. In total, 76% of the cases were MCPyV-negative, whereas 4% were MCPyV-positive. The most frequent histopathological pattern was that of an SCC in situ combined with a dermal MCC (36%), followed by both an in situ and invasive SCC combined with a dermal MCC (20%). Forty-seven percent of all cases fitted in the morphology of the so-called “collision tumors”. Three combined MCC cases that would fit in the morphological category of collision tumors presented both squamous and neuroendocrine elements in their respective nodal metastases. The mean overall survival was 36 months, comparable to that of pure, MCPyV-negative MCC. This review found similarly aggressive behavior for combined MCC and SCC and pure, MCPyV-negative MCC. Preliminary data strongly suggest that all MCPyV-negative MCC tumors, whether combined or pure, are part of a common spectrum.

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Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity

Cited by 2 publications

References 36 publications

Mast Cells density in relation to recurrency, lymphovascular Invasion and MCPyV status in Human Merkel Cell Carcinoma: a descriptive study with prognostic implications

Mast Cells density in relation to recurrency, lymphovascular Invasion and MCPyV status in Human Merkel Cell Carcinoma: a descriptive study with prognostic implications

Combined Merkel Cell Carcinoma and Squamous Cell Carcinoma: A Systematic Review

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