Merkel Cell Carcinoma

Pulitzer, Melissa

doi:10.1016/j.path.2017.01.013

Cited by 53 publications

(65 citation statements)

References 49 publications

(59 reference statements)

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“…107,113 Stromal fibrosis and inflammation may also be present in MCC. 105 However, despite that overlap in stromal features, the classic BCC myxoinflammatory stroma is not observed in MCC.…”

Section: Sebaceous Carcinomamentioning

confidence: 99%

“…Although less than 1% of malignant skin tumors are MCCs, 104 it is a significant cause of death from skin cancer, with a mortality rate of 30% to 75%. 105 About one-third of patients will have metastatic disease at the time of diagnosis. 106 Because of the increased mortality and high metastatic potential of MCC, it must be distinguished from less-aggressive lesions, such as BCC.…”

Section: Sebaceous Carcinomamentioning

confidence: 99%

“…[108][109][110][111] Both MCC and BCC may have focal or extensive squamous differentiation. 105 Peripheral palisading may be identified in a few MCC tumors but is typically focal. 107,[112][113][114][115] Clefts between aggregates of MCC and adjacent stroma are not infrequently identified in MCC (Figure 8, C).…”

Section: Sebaceous Carcinomamentioning

confidence: 99%

“…Although tumor cells of BCC are characteristically elongated with hyperchromatic nuclei, visible cytoplasm, and scattered mitotic activity and necrosis, tumor cells of MCC have a homogenous salt-and-pepper chromatin pattern, nuclear molding, scant cytoplasm, and abundant mitotic activity and necrosis. 105 Merkel cell carcinoma cells share antigenic profiles of both epithelial and neuroendocrine cells. They express epithelial markers, such as low-molecular-weight keratins and EMA, as well as neuroendocrine markers, including chromogranin and synaptophysin.…”

Section: Sebaceous Carcinomamentioning

confidence: 99%

“…there is membranous or cytoplasmic cytokeratin staining, with or without paranuclear dots. 105,117 Most MCCs express CK20, whereas that stain is negative in BCC. 114 Merkel cell polyomavirus large T-antigen protein, expressed in approximately 70% to 80% of MCCs, is a highly specific marker for distinguishing MCC from BCC.…”

Section: Sebaceous Carcinomamentioning

confidence: 99%

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Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. Objective.— To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. Data Sources.— Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. Conclusions.— In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

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Section: Sebaceous Carcinomamentioning

confidence: 99%

Section: Sebaceous Carcinomamentioning

confidence: 99%

Section: Sebaceous Carcinomamentioning

confidence: 99%

Section: Sebaceous Carcinomamentioning

confidence: 99%

Section: Sebaceous Carcinomamentioning

confidence: 99%

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Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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Blastic plasmacytoid dendritic cell neoplasm of skin, a rare dermatohematologic malignancy—A case report

Edjtemaei,

Ghanadan,

Ameli

2024

Clinical Case Reports

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Key Clinical MessageBlastic plasmacytoid dendritic cell neoplasm is a rare hematologic malignancy and appropriate diagnosis encounters difficulties in both clinical and pathologic aspects. This case report aims to present a clinical case to help familiar clinicians and pathologists with this rare entity.AbstractBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is an uncommon hematologic malignancy. Because of the rarity of the disease and aggressive behavior, we present this case. A 71‐year‐old man presented with a forehead ulcerated skin lesion. On histopathologic examination, pan‐dermal atypical mononuclear infiltrate, consisting of small‐medium sized cells with fine chromatin pattern was seen without epidermotropism which were immunoreactive for CD123, CD56, TdT and CD4, while negative for CD3, CD20, and MPO that confirmed the diagnosis of BPDCN. BPDCN is a highly aggressive hematologic malignancy derived from plasmacytoid dendritic cells. Male‐to‐female ratio is 3.3:1. Skin involvement can present as either an isolated purplish nodule or disseminated purplish nodules or papules or macules. On microscopic examination, skin involvement is characterized by monomorphic infiltrates of immature neoplastic cells with blastoid morphology, involving the superficial and deep dermis, often with extension into the subcutis with epidermal spare. Immunophenotyping shows usually positive reactions for CD123, CD45, CD4, CD56, TCL1, CD2AP, CD43, BCL2, TdT, Granzyme B, and TCF4, whereas tumor cells are negative for CD3, CD19, CD20, MPO, CD13 and Lysozyme. Differential diagnoses of BPDCN include myeloid sarcoma, myelomonocytic leukemia, mature plasmacytoid dendritic cell proliferation (MPDCP) and Merkel cell carcinoma. Pathologists ought to be familiar with this WHO entity for early disease diagnosis, because of disease rarity and diagnosis difficulties.

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Diagnostic clues for differentiating Merkel cell carcinoma from lymphoma in fine‐needle aspiration cytology

Liu

Lai

Chang

et al. 2021

Diagnostic Cytopathology

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Nodal fine needle aspiration (FNA) is usually the first procedure in the work-up of malignancy of unknown primary. Merkel cell carcinoma (MCC) is an aggressive cutaneous cancer more common in Caucasians but rare among Asians. It is a diagnostic challenge in evaluating FNA from a metastatic MCC without the knowledge of a current or prior history of skin cancer. We report the case of a Taiwanese male with cervical and axillary masses. The diagnosis of the FNA from the axillary lymph node was lymphoproliferative lesion suspicious for lymphoma. The histopathological evaluation of nodal biopsy revealed a metastatic neuroendocrine carcinoma and the subse-

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Merkel Cell Carcinoma

Cited by 53 publications

References 49 publications

Histologic Mimics of Basal Cell Carcinoma

Histologic Mimics of Basal Cell Carcinoma

Blastic plasmacytoid dendritic cell neoplasm of skin, a rare dermatohematologic malignancy—A case report

Diagnostic clues for differentiating Merkel cell carcinoma from lymphoma in fine‐needle aspiration cytology

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