Merging Organolithium Chemistry and Stereoselective Biocatalysis: Transformation of Aromatic Nitriles into Chiral Alcohols
Nicolás Ríos‐Lombardía,
Gloria Morís‐Menéndez,
Iván Lavandera
et al.
Abstract:The combination of RLi‐mediated organic transformations (under air and at room temperature) with a subsequent stereoselective biocatalytic reaction is for the first time presented. Most of the previous asymmetric chemoenzymatic routes have been limited to the concomitant or sequential combination of transition metals/organocatalysts with enzymes. However, the use of polar organometallic reagents (RLi) in the design of these stereoselective hybrid protocols has been totally neglected, as far as we are concerned… Show more
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